Patents Assigned to American International Biotechnology, LLC
  • Methods of analyzing virus-derived therapeutics
    Patent number: 10662464
    Abstract: Described herein are massively parallel sequencing methods for virus-derived therapeutics such as viral vaccines, including the PVS-RIPO vaccine. The methods allow for the determination of micro-heterogeneity and quantitation of low frequency sequence variants and in the case of PVS-RIPO, are expected to replace the monkey neurovirulence safety test (MNVT) and the mutant analysis by PCR and restriction enzyme cleavage (MAPREC) methods that are currently used to screen lots of RNA virus-derived therapeutics.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: May 26, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Serv, American International Biotechnology, LLC
    Inventors: Trevor Lane Broadt, Michael D. Harwich, William T. Budd, Gregory A. Meyers
  • METHODS OF ANALYZING VIRUS-DERIVED THERAPEUTICS
    Publication number: 20180237835
    Abstract: Described herein are massively parallel sequencing methods for virus-derived therapeutics such as viral vaccines, including the PVS-RIPO vaccine. The methods allow for the determination of micro-heterogeneity and quantitation of low frequency sequence variants and in the case of PVS-RIPO, are expected to replace the monkey neurovirulence safety test (MNVT) and the mutant analysis by PCR and restriction enzyme cleavage (MAPREC) methods that are currently used to screen lots of RNA virus-derived therapeutics.
    Type: Application
    Filed: July 29, 2016
    Publication date: August 23, 2018
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, American International Biotechnology, LLC
    Inventors: Trevor Lane Broadt, Michael D. Harwich, William T. Budd, Gregory A. Meyers