Abstract: The present disclosure provides methods for monitoring subject (e.g., patient) adherence to lurasidone therapy, for example as a component of treating a subject for a mental health disorder such as schizophrenia.
Type:
Grant
Filed:
December 11, 2014
Date of Patent:
March 28, 2017
Assignee:
AMERITOX, LTD.
Inventors:
Jeffrey Enders, Erin Strickland, Gregory L. McIntire, Ayodele Morris
Abstract: Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In an embodiment, the method comprises measuring a drug level in fluid of a subject and normalizing the measured drug level as a function of one or more parameters associated with the subject. The drug level can be normalized using second order quantile regression. Embodiments of the methods can use both primary and secondary metabolites in the normalization; allow changing variance by dose; allow asymmetry in variance above and below the estimated median values; and/or use analytic variables with stable estimates, such as, for example, variables associated with the percentile for ?1 standard deviation, the percentile for 0 standard deviation, and the percentile for +1 standard deviation.
Abstract: Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In one embodiment, the method comprises measuring a drug level in fluid of a subject and normalizing said measured drug level as a function of one or more parameters associated with the subject. The normalized drug level is compared to a reference value and associated confidence intervals or to a concentration range. The reference value and associated confidence intervals and/or the concentration range may be normalized based on one or more parameters associated with subjects in a reference population.
Abstract: The present disclosure provides methods and apparatuses for generating toxicology reports. Using the methods and apparatus disclosed herein, physicians can more easily understand toxicological lab test results. Physicians receive a toxicology report that explains, in plain language, the toxicological lab test results. A rules engine provides rules for interpreting the toxicological lab test results. Detailed explanations are associated with the rules, and the explanations appear on the toxicology report. The toxicology report greatly reduces the need for the physician to call the toxicology scientist.
Type:
Grant
Filed:
December 3, 2007
Date of Patent:
January 22, 2013
Assignee:
Ameritox, Ltd.
Inventors:
Ronald C. Backer, William Pace, Patricia Patrick, Sybil Patricia Lowry, Shesh Rau, Joel McEndree
Abstract: Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In one embodiment, the method comprises measuring a drug level in fluid of a subject and normalizing said measured drug level as a function of one or more parameters associated with the subject. The normalized drug level is compared to a reference value and associated confidence intervals or to a concentration range. The reference value and associated confidence intervals and/or the concentration range may be normalized based on one or more parameters associated with subjects in a reference population.
Abstract: Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In one embodiment, the method comprises measuring a drug level in fluid of a subject and normalizing said measured drug level as a function of one or more parameters associated with the subject. The normalized drug level is compared to a reference value and associated confidence intervals or to a concentration range. The reference value and associated confidence intervals and/or the concentration range may be normalized based on one or more parameters associated with subjects in a reference population.
Abstract: Methods for monitoring subject compliance with a prescribed treatment regimen are disclosed. In one embodiment, the method comprises measuring a drug level in fluid of a subject and normalizing said measured drug level as a function of one or more parameters associated with the subject. The normalized drug level is compared to a reference value and associated confidence intervals or to a concentration range. The reference value and associated confidence intervals and/or the concentration range may be normalized based on one or more parameters associated with subjects in a reference population.
Abstract: The present disclosure provides methods and apparatuses for generating toxicology reports. Using the methods and apparatus disclosed herein, physicians can more easily understand toxicological lab test results. Physicians receive a toxicology report that explains, in plain language, the toxicological lab test results. A rules engine provides rules for interpreting the toxicological lab test results. Detailed explanations are associated with the rules, and the explanations appear on the toxicology report. The toxicology report greatly reduces the need for the physician to call the toxicology scientist.
Type:
Application
Filed:
December 3, 2007
Publication date:
July 31, 2008
Applicant:
Ameritox, Ltd.
Inventors:
Ronald C. Backer, William Pace, Patricia Patrick, Sybil Patricia Lowry, Shesh Rau, Joel McEndree