Patents Assigned to Amgen
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Patent number: 12364723Abstract: Provided herein is a powder comprising a live, attenuated virus, recombinant human serum albumin (rHSA), a sugar other than lactose, a sugar alcohol, a source of phosphate, a source of chloride, wherein the composition is substantially free of lactose, gelatin, antibiotic, and free amino acids. In exemplary aspects, the powder is a lyophilizate of a liquid composition. Related liquid compositions, methods of preparing an oncolytic virus for administration and methods of treating melanoma are also provided herein.Type: GrantFiled: December 27, 2019Date of Patent: July 22, 2025Assignee: AMGEN INC.Inventor: Enrique Alexander Flood
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Patent number: 12352755Abstract: Systems and methods that facilitate the automatic (or substantially automatic) preparation of a sample of a product containing molecules for analysis and automatic (or substantially automatic) performance of an assay of that sample. Thus, the preparation and analysis can be performed substantially in-real time, or, in other words, much more quickly than presently allowed by conventional systems and methods.Type: GrantFiled: February 14, 2020Date of Patent: July 8, 2025Assignee: AMGEN INC.Inventors: Chao-Hsiang Wu, Gang Xue, Brandon Zachary Sarich, Michael R. Berke, Jacob Sebastain, Pik Chan
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Patent number: 12350480Abstract: An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement.Type: GrantFiled: July 20, 2022Date of Patent: July 8, 2025Assignee: AMGEN INC.Inventors: Michael Denzer, Robert W. Swift, Neal Johnston, Gabriele Ganzitti, Kenneth R. Ewing, Suhas Krishna
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Patent number: 12350469Abstract: Impact testing apparatuses are disclosed which simulate and measure various impact-related events associated with the operation of a drug delivery device. The impact testing apparatus may include an impactor configured to simulate a plunger rod of the drug delivery device, and a guide sleeve configured to receive a syringe corresponding to the drug delivery device. The syringe may have a proximal end, a distal end defining an outlet, and an interior chamber extending between the proximal and distal ends and carrying a plunger. Additionally, the impact testing apparatus may include an energy source configured to reduce a distance between the impactor and the plunger so that the impactor strikes the plunger. Various sensors may be included to measure characteristics of one or more impacts caused by the impactor. Methods of impact testing a syringe filled with a fluid and carrying a plunger are also disclosed.Type: GrantFiled: February 27, 2024Date of Patent: July 8, 2025Assignee: AMGEN INC.Inventors: Julian Jazayeri, Sean Fitzgibbon, Joshua Tamsky, Christopher R. Folk
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Publication number: 20250215086Abstract: In some aspects, the present disclosure describes stable formulations comprising pembrolizumab, methods of making stable pharmaceutical formulations thereof, and methods of using stable pharmaceutical formulations thereof.Type: ApplicationFiled: June 30, 2023Publication date: July 3, 2025Applicant: Amgen Inc.Inventors: Shantanu Sule, Li Gu, Kelsey O'Donnell, Monica M. Goss
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Patent number: 12344668Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.Type: GrantFiled: September 24, 2020Date of Patent: July 1, 2025Assignee: AMGEN INC.Inventors: Jian Wu, Nicole Sabo, Michael De La Cruz, Gregory Flynn
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Patent number: 12337136Abstract: Kits for a drug delivery device or system include a housing having compartments, components to be secured within the compartments, and an instruction manual providing a series of steps. In some kits, a page of the instruction manual providing a step associated with a component does not overlay the compartment in which the associated component is to be secured, whereas all preceding pages do overlay the compartment, such that the step and the associated component are first displayed together. In some kits, a color is displayed with a compartment and with a step associated with the component to be secured in the compartment. In some kits, the housing includes two chambers, each chamber having the compartments in which components associated with a first subset of steps and a second subset of steps, respectively are secured.Type: GrantFiled: April 12, 2023Date of Patent: June 24, 2025Assignee: AMGEN INC.Inventors: Ronnie Paul Mounce, Gonghao Wang, Austin Wanek, Katie Lucchesi, Brian Stonecipher
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Patent number: 12329944Abstract: A drive system for a drug delivery system includes a pressure chamber, a primary container, and a pressurized fluid. The pressure chamber has an outer surface and an inner surface that defines an interior volume. The primary container also has an outer surface and an inner surface that defines an interior volume to store a medicament to be administered to a user. The primary container is at least partially disposed within the interior volume of the pressure chamber. The pressurized fluid is disposed in the interior volume of the pressure chamber and is pressurized to exert a pressure on at least a portion of the outer surface of the primary container.Type: GrantFiled: July 16, 2020Date of Patent: June 17, 2025Assignee: AMGEN INC.Inventor: Gregory Thomas Nowak
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Patent number: 12329720Abstract: A drug delivery system includes a delivery container, a first drug insertion port, at least one additional drug insertion port, and an IV connection port. The delivery container includes upper, lower, first side, and second side portions, and further includes a tapered region extending between the first side portion and the second side portion. The first drug insertion port is positioned at the lower portion of the delivery container and has a first coupling mechanism. The at least one additional drug insertion port is also positioned at the lower portion of the delivery container, but includes a second coupling mechanism that is different than the first coupling mechanism. The IV connection port is positioned at the lower portion of the delivery container adjacent to a lower portion of the tapered region.Type: GrantFiled: February 5, 2020Date of Patent: June 17, 2025Assignee: AMGEN INC.Inventors: Chia-Jung Wu, Nicholas J. Clark, Ronak Maheshwari, Heather N. Franey
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Patent number: 12329943Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.Type: GrantFiled: February 1, 2022Date of Patent: June 17, 2025Assignee: AMGEN INC.Inventors: Francisca Tan-Malecki, Ronald Forster, Scott M. Nunn, Mark D. Holt, Son C. Tran, Sheldon Moberg
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Publication number: 20250188447Abstract: The present invention is directed to a method for optimizing the expression levels of a multi-chain protein wherein the protein comprises at least two different polypeptide chains. The generation of multi-chain proteins presents great challenges due to the pairing/folding of new quaternary structures composed of multiple polypeptide chains, particularly when pairing antibody heavy and light chains in a multispecific format. Of critical import to efficient and proper assembly of multiple polypeptide chain molecules is expression of the different chains at the proper ratio within the cell. The present invention addresses these issues.Type: ApplicationFiled: March 7, 2023Publication date: June 12, 2025Applicant: AMGEN INC.Inventors: Fuyi CHEN, Marissa MOCK, Edward J. BELOUSKI
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Publication number: 20250188036Abstract: Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound AType: ApplicationFiled: March 6, 2023Publication date: June 12, 2025Applicant: AMGEN INC.Inventors: Austin Gerald SMITH, Padmini KAVURU, Peter DORNAN, Xijie DAI
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Patent number: 12325737Abstract: Provided herein are methods of producing an antibody composition comprising a desired or predetermined or pre-selected level of total afucosylated (TAF) glycoforms. In exemplary embodiments, the method comprises maintaining glycosylation-competent cells in a cell culture medium comprising fucose and/or glucose at a specific concentration as described herein, depending on the level of TAF glycoforms desired. Related compositions comprising glycosylated proteins and TAF glycoforms thereof are also provided herein. Also provided are cell culture media.Type: GrantFiled: March 26, 2019Date of Patent: June 10, 2025Assignee: AMGEN INC.Inventors: Prince Bhebe, Matthew Jerums, Irene Liu, Kurt Kunas
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Patent number: 12319691Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.Type: GrantFiled: April 28, 2023Date of Patent: June 3, 2025Assignees: Amgen Inc., Vigil Neuroscience, Inc.Inventors: Lara C. Czabaniuk, Timothy Hopper, Jonathan B. Houze, Gwenaella Rescourio, Vincent Santora, Haoxuan Wang, Ryan D. White, Alice R. Wong, Yongwei Wu
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Patent number: 12311151Abstract: A drug delivery device may include a housing defining a longitudinal axis and having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member, the plunger including a body portion having an inner wall defining an axial chamber and an outer wall cooperating with the inner wall to define a body thickness. The device may further include a plunger biasing member disposed at least partially within the axial chamber, the plunger biasing member configured to urge the plunger toward the distal end of the drug storage container.Type: GrantFiled: December 8, 2023Date of Patent: May 27, 2025Assignee: AMGEN INC.Inventors: Emil Finkelstein, Soren Forbech Skall, Lars Eilertsen, Matias Melander, Jan Jensen
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Patent number: D1078994Type: GrantFiled: September 24, 2024Date of Patent: June 10, 2025Assignee: AMGEN INC.Inventors: Jakob Halkjaer Kvist, Joshua Jay Dudman
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Patent number: D1078995Type: GrantFiled: September 24, 2024Date of Patent: June 10, 2025Assignee: AMGEN INC.Inventor: David Lavmand Muller
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Patent number: D1078996Type: GrantFiled: September 24, 2024Date of Patent: June 10, 2025Assignee: AMGEN INC.Inventor: David Lavmand Muller
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Patent number: D1078997Type: GrantFiled: September 24, 2024Date of Patent: June 10, 2025Assignee: AMGEN INC.Inventors: Jakob Halkjaer Kvist, Joshua Jay Dudman
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Patent number: D1078998Type: GrantFiled: September 24, 2024Date of Patent: June 10, 2025Assignee: AMGEN INC.Inventors: Jakob Halkjaer Kvist, Joshua Jay Dudman