Abstract: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
Type:
Grant
Filed:
April 15, 2010
Date of Patent:
June 28, 2011
Assignee:
Amgen Mountain View, Inc.
Inventors:
Willem P. C. Stemmer, D. Victor Perlroth, Sanjeev Satyal, Benjamin M. Alba, Alice Bakker, Amy N. Duguay, Qiang Lui, Joshua Silverman, Richard Smith, Candace Swimmer
Abstract: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
Type:
Application
Filed:
April 15, 2010
Publication date:
November 18, 2010
Applicant:
AMGEN MOUNTAIN VIEW, INC.
Inventors:
WILLEM P.C. STEMMER, D. Victor PERLROTH, SANJEEV SATYAL, BENJAMIN M. ALBA, ALICE BAKKER, AMY N. DUGUAY, QIANG LIU, JOSHUA SILVERMAN, RICHARD SMITH, CANDACE SWIMMER
Abstract: Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
Type:
Grant
Filed:
June 17, 2005
Date of Patent:
September 28, 2010
Assignee:
Amgen Mountain View, Inc.
Inventors:
Willem P. C. Stemmer, D. Victor Perlroth, Sanjeev Satyal, Benjamin M. Alba, Alice Bakker, Amy N. Duguay, Qiang Liu, Joshua Silverman, Richard Smith, Candace Swimmer
Abstract: Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.