Patents Assigned to Amgen
  • Substituted triazinyl acrylamide derivatives and methods of use
    Patent number: 6881737
    Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and polycystic kidney disease.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: April 19, 2005
    Assignee: Amgen Inc.
    Inventors: John L. Buchanan, Joseph L. Kim, Perry M. Novak, Joseph J. Nunes, Vinod F. Patel
  • Substituted alkylamine derivatives and methods of use
    Patent number: 6878714
    Abstract: Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: April 12, 2005
    Assignee: Amgen Inc.
    Inventors: Benny Askew, Jeffrey Adams, Shon Booker, Guoqing Chen, Lucian V. DiPietro, Daniel Elbaum, Julie Germain, Stephanie D. Geuns-Meyer, Gregory J. Habgood, Michael Handley, Qi Huang, Tae-Seong Kim, Aiwen Li, Nobuko Nishimura, Rana Nomak, Vinod F. Patel, Babak Riahi, Joseph L. Kim, Ning Xi, Kevin Yang, Chester Chenguang Yuan
  • Inhibition of retrovirus infection
    Patent number: 6869925
    Abstract: Methods and pharmaceutical compositions are provided to prevent retroviral infections of host cells. More particularly, the invention relates to prevention of HIV infection of human cells by serine leukocyte protease inhibitor (SLPI).
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 22, 2005
    Assignees: Amgen Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Stephen Eisenberg, Sharon M. Wahl, Robert C. Thompson
  • Tool for use with a medication vial and/or a syringe
    Publication number: 20050056121
    Abstract: A tool for use with a medication vial and a syringe comprises a housing having a top side, a bottom side, and a surrounding edge, a slotted aperture defined in the housing and including a flange shaped to engage vial cap, a cylindrical aperture defined in the housing and sized to permit placement of a forward portion of the syringe including a cap into the cylindrical aperture, an actuator button mounted to the housing, and a gripper mounted within the housing and having a pair of opposed edges, with the gripper responsive to movement of the actuator button to permit movement of the edges between a retracted position in which the edges are disposed away from a central portion of the cylindrical aperture, and an extended position in which the edges are displaced toward the central portion of the cylindrical aperture.
    Type: Application
    Filed: August 3, 2004
    Publication date: March 17, 2005
    Applicant: AMGEN, INC
    Inventor: Scott Lyman
  • Substituted triazinyl amide derivatives and methods of use
    Patent number: 6864255
    Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and angiogenesis-related disease.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: March 8, 2005
    Assignee: Amgen Inc.
    Inventors: Stephanie D. Geuns-Meyer, Lucian V. DiPietro, Joseph L. Kim, Vinod F. Patel
  • Il-17 like molecules and uses thereof
    Publication number: 20050048029
    Abstract: Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.
    Type: Application
    Filed: June 17, 2004
    Publication date: March 3, 2005
    Applicant: AMGEN, INC.
    Inventors: Eugene Medlock, Richard Yeh, Scott Silbiger, Gary Elliott, Hung Nguyen, Shuqian Jing
  • Antiinflammation agents
    Publication number: 20050043330
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
    Type: Application
    Filed: August 26, 2004
    Publication date: February 24, 2005
    Applicant: Amgen Inc.
    Inventors: Michelle Browner, David Clark, Timothy Cushing, Xiaolin Hao, Ronald Hawley, Xiao He, Juan Jaen, Sharada Labadie, Marie-Louise Smith, Francisco Talamas, Nigel Walker, Marc Labelle
  • Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors
    Patent number: 6858409
    Abstract: Compounds are disclosed having the general formula R1—X—R2, wherein R1 and R2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R1 and R2 may be the same or different. Preferred R1 and R2 groups are interleukin-1 receptor antagonist, 30 kDa TNF inhibitor, interleukin-2 receptors and CR1 and muteins thereof. Also included are site selectively modified interleukin-1 receptor antagonist and 30 kDa TNF inhibitor.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 22, 2005
    Assignees: Amgen Inc., The Regents of the University of Colorado
    Inventors: Robert C. Thompson, Charles H. Hannum, Stephen P. Eisenberg, William P. Arend, Fenneke G. Joslin, Andreas Sommer
  • Fused heterocyclic compounds
    Patent number: 6858619
    Abstract: Compounds useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor are provided that have the formula: wherein A and B are CR?; V is either a bond and W is —N(R?)—, or else V is —N(R?)— and W is a bond; Z is —N(R)—CH2—; R1, R2, R3, R4, R?, R?, and R are as defined herein; the subscript n is an integer from 0 to 8; and ?is a benzene ring. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders, are also provided.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: February 22, 2005
    Assignee: Amgen Inc.
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Shugui Huang, Leping Li, Jeffrey Thomas Mihalic
  • Inhibitors of apoptosis
    Patent number: 6855815
    Abstract: The invention provides methods and compositions relating to novel human cellular inhibitor of apoptosis proteins (c-IAP1/2) comprising a series of defined structural domain repeats and/or a RING finger domain; in particular, at least two of: a particular first domain repeat, a particular second domain repeat, and a particular third domain repeat, and/or a particular RING finger domain. The proteins provide a c-IAP specific function, with preferred proteins being capable of modulating the induction of apoptosis; for example, by binding a human tumor necrosis factor receptor associated factor (TRAF). The compositions include nucleic acids which encode the subject c-IAP and hybridization probes and primers capable of hybridizing with the disclosed c-IAP genes. The invention includes methods of using the subject compositions in therapy, in diagnosis and in the biopharmaceutical industry.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: February 15, 2005
    Assignee: Amgen Inc.
    Inventors: Mike Rothe, David V. Goeddel
  • Method of stimulating growth of melanocyte cells by administering stem cell factor
    Patent number: 6852313
    Abstract: Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: February 8, 2005
    Assignee: Amgen Inc.
    Inventors: Krisztina M. Zsebo, Robert A. Bosselman, Sidney V. Suggs, Francis H. Martin
  • Fhm, a novel member of the TNF ligand supergene family
    Patent number: 6852839
    Abstract: The present invention provides a purified polynucleotide encoding a novel polypeptide, designated Fhm, which belongs to the TNF gene superfamily; to purified Fhm polypeptide molecules; to antibodies that bind Fhm; to materials comprising such molecules; and to methods of using such molecules.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: February 8, 2005
    Assignee: Amgen, Inc.
    Inventors: Hailing Hsu, Scott Kenneth Wooden, William James Boyle
  • Methods and compositions for treating IgE-related disease using NNT-1 inhibitors
    Patent number: 6849260
    Abstract: Disclosed are novel methods and compositions for treating IgE-related diseases using NNT-1 inhibitors. In one embodiment, the present invention relates to a method of treating IgE-related diseases using a selective binding agent to NNT-1. In another embodiment, the present invention relates to a method of treating IgE-related diseases using an NNT-1 expression modulator. Methods of modulating IgE levels, and of diagnosing, preventing and/or treating certain types of allergic diseases using NNT-1 inhibitors are also disclosed.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: February 1, 2005
    Assignee: Amgen Inc.
    Inventor: Giorgio Senaldi
  • Antibodies to the metalloproteinase inhibitor
    Patent number: 6849450
    Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: February 1, 2005
    Assignees: Childrens Hospital of Los Angeles, Amgen Inc.
    Inventors: Keith E. Langley, Yves A. DeClerck, Thomas C. Boone
  • Integrin inhibitors and their methods of use
    Patent number: 6849639
    Abstract: The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as a ?v?3, ?v?5, ?v?6, ?5?1 and the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: February 1, 2005
    Assignee: Amgen Inc.
    Inventors: Celia Dominguez, Guoqing Chen, Ning Xi, Shimin Xu, Nianhe Han, Qingyian Liu, Qi Huang, Aaron Siegmund, Michael Handley, Longbin Liu, Alexander Kiselyov
  • Antiinflammation agents
    Patent number: 6846834
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: January 25, 2005
    Assignees: Amgen Inc., Syntex (U.S.A.) LLC
    Inventors: Michelle F. Browner, David L. Clark, Timothy D. Cushing, Xiaolin Hao, Ronald C. Hawley, Xiao He, Juan C. Jaen, Sharada S. Labadie, Marie-Louise Smith, Francisco X. Talamas, Nigel P. C. Walker, Marc Labelle
  • Stem cell factor compositions
    Patent number: 6841147
    Abstract: Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: January 11, 2005
    Assignee: Amgen, Inc.
    Inventors: Krisztina M. Zsebo, Robert A. Bosselman, Sidney V. Suggs, Francis H. Martin
  • Carboxylic acid substituted heterocycles, derivatives thereof and methods of use
    Patent number: 6838454
    Abstract: Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: January 4, 2005
    Assignee: Amgen Inc.
    Inventors: Kevin Koch, Andreas Termin, John A. Josey
  • Thrombopoietic compounds
    Patent number: 6835809
    Abstract: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: December 28, 2004
    Assignee: Amgen Inc.
    Inventors: Chuan-Fa Liu, Ulrich Feige, Janet C. Cheetham
  • Pyrimidine derivatives
    Patent number: 6835726
    Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: December 28, 2004
    Assignee: Amgen Inc.
    Inventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers