Patents Assigned to Amicrobe, Inc.
  • Compositions and uses of antimicrobial materials with tissue-compatible properties
    Patent number: 11298401
    Abstract: Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: April 12, 2022
    Assignee: Amicrobe, Inc.
    Inventors: Michael P. Bevilacqua, Diego Benitez, Jarrod A. Hanson
  • Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety
    Patent number: 11285189
    Abstract: The present invention relates to an antimicrobial pharmaceutical composition, comprising an aqueous carrier, and an antimicrobial synthetic cationic polypeptide(s) dispersed in the aqueous carrier at a concentration in the range of about 0.01% to about 5%, by weight based on total weight of the antimicrobial pharmaceutical composition, wherein the antimicrobial synthetic cationic polypeptide(s) comprises a plurality of positively charged amino acid units at neutral pH, and fulfils certain viscosity and toxicity requirements. The invention further relates to a method of preventing microbial contamination of tissues other than intact, healthy skin, comprising administering the present antimicrobial pharmaceutical composition in an amount effective to at least partially protect the tissue site from becoming contaminated with microbes.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: March 29, 2022
    Assignee: AMICROBE, INC.
    Inventors: Michael P. Bevilacqua, Daniel J. Huang, Doug Looker
  • Composition with high antimicrobial activity and low toxicity
    Patent number: 10448634
    Abstract: Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: October 22, 2019
    Assignees: The Regents of the University of California, Amicrobe, Inc.
    Inventors: Michael P. Bevilacqua, Diego Benitez, Timothy J. Deming, Jarrod A. Hanson, Lucas Koziol
  • Compositions and uses of antimicrobial materials with tissue-compatible properties
    Patent number: 9446090
    Abstract: Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 20, 2016
    Assignee: AMICROBE, INC.
    Inventors: Michael P. Bevilacqua, Diego Benitez, Jarrod A. Hanson
  • Compositions and uses of materials with high antimicrobial activity and low toxicity
    Patent number: 9017730
    Abstract: Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: April 28, 2015
    Assignees: The Regents of the University of California, Amicrobe, Inc.
    Inventors: Michael P. Bevilacqua, Diego Benitez, Timothy J. Deming, Jarrod A. Hanson, Lucas Koziol
  • COMPOSITIONS AND USES OF MATERIALS WITH HIGH ANTIMICROBIAL ACTIVITY AND LOW TOXICITY
    Publication number: 20130267458
    Abstract: Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
    Type: Application
    Filed: February 25, 2013
    Publication date: October 10, 2013
    Applicants: Amicrobe, Inc., The Regents of the University of California
    Inventors: Michael P. Bevilacqua, Diego Benitez, Timothy J. Deming, Jarrod A. Hanson, Lucas Koziol