Abstract: Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
Type:
Grant
Filed:
March 1, 2022
Date of Patent:
June 25, 2024
Assignee:
Amicrobe, Inc.
Inventors:
Michael P. Bevilacqua, Diego Benitez, Jarrod A. Hanson
Abstract: Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
Type:
Grant
Filed:
August 18, 2016
Date of Patent:
April 12, 2022
Assignee:
Amicrobe, Inc.
Inventors:
Michael P. Bevilacqua, Diego Benitez, Jarrod A. Hanson
Abstract: Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
Type:
Grant
Filed:
April 22, 2015
Date of Patent:
October 22, 2019
Assignees:
The Regents of the University of California, Amicrobe, Inc.
Inventors:
Michael P. Bevilacqua, Diego Benitez, Timothy J. Deming, Jarrod A. Hanson, Lucas Koziol
Abstract: Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
Type:
Grant
Filed:
February 25, 2013
Date of Patent:
April 28, 2015
Assignees:
The Regents of the University of California, Amicrobe, Inc.
Inventors:
Michael P. Bevilacqua, Diego Benitez, Timothy J. Deming, Jarrod A. Hanson, Lucas Koziol
Abstract: Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.
Type:
Application
Filed:
February 25, 2013
Publication date:
October 10, 2013
Applicants:
Amicrobe, Inc., The Regents of the University of California
Inventors:
Michael P. Bevilacqua, Diego Benitez, Timothy J. Deming, Jarrod A. Hanson, Lucas Koziol