Patents Assigned to Amino Up Chemical Co., Ltd.
  • Publication number: 20190201395
    Abstract: The present invention provides a heat shock protein expression-inducing agent, more specifically, a heat shock protein expression-inducing agent comprising a compound represented by formula (I): wherein R is a lower alkyl, phenyl, or hydroxyphenyl, or a salt thereof.
    Type: Application
    Filed: May 26, 2017
    Publication date: July 4, 2019
    Applicants: AMINO UP CHEMICAL CO., LTD., OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Kazunori GOTO, Jun NAKAHIGASHI, Atsuya SATO, Yosuke HIRAYAMA, Moeri HORIKOSHI, Noriyuki KOUDA, Syoichiro INOUE, Ikutaro SATO, Manami KATO
  • Patent number: 10183007
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 22, 2019
    Assignees: Usien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd., Nagasaki University
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Patent number: 9610279
    Abstract: A method for induction of a heat shock protein, anti-stress or regulation of an autonomic nerve comprises: administering a mammalian subject in need thereof a composition comprising an effective amount of hydroxymethylfurfural derivative of the following formula: wherein R is selected from the group consisting of formula (I): (II): HOOCCH2COCO—, (III): HOOCCH2CH2COCO—, and (IV): a hydrogen atom.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: April 4, 2017
    Assignee: AMINO UP CHEMICAL CO., LTD.
    Inventors: Hiroshi Nishioka, Tomohiro Ito, Takahiro Maeda
  • Patent number: 9573920
    Abstract: A compound is represented by Formula (I) or (II) described below. A medicine includes, as an active ingredient, a compound represented by Formula (I), (II), or (III) described below.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: February 21, 2017
    Assignees: AMINO UP CHEMICAL CO., LTD, THE RITSUMEIKAN TRUST
    Inventors: Yukinobu Ikeya, Mikio Nishizawa, Takehito Miura
  • Patent number: 9464292
    Abstract: The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: October 11, 2016
    Assignees: AMINO UP CHEMICAL CO., LTD, KANSAI MEDICAL UNIVERSITY
    Inventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
  • Patent number: 9359321
    Abstract: The hydroxymethylfurfural derivative is represented by the general formula (A) (wherein, R is selected from the group consisting of the following formula (I), (II) HOOCCH2COCO—, (III) HOOCCH2CH2COCO—, and (IV) a hydrogen atom).
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: June 7, 2016
    Assignee: AMINO UP CHEMICAL CO., LTD
    Inventors: Hiroshi Nishioka, Tomohiro Ito, Takahiro Maeda
  • Publication number: 20160151329
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 2, 2016
    Applicants: Nagasaki University, Usaien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd.
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Patent number: 9125926
    Abstract: Provided are compositions comprising an active ingredient having antispasmodic and/or prokinetic activity, preferably vicenin 2 or biologically active analogs thereof.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: September 8, 2015
    Assignee: AMINO UP CHEMICAL CO. LTD
    Inventors: Hajime Fujii, Sybille Buchwald-Werner
  • Publication number: 20150191733
    Abstract: The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
    Type: Application
    Filed: December 12, 2014
    Publication date: July 9, 2015
    Applicants: AMINO UP CHEMICAL CO., LTD, KANSAI MEDICAL UNIVERSITY
    Inventors: Tadayoshi OKUMURA, Mikio NISHIZAWA, Yasuo KAMIYAMA, Koji WAKAME, Takehito MIURA
  • Patent number: 8975023
    Abstract: The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or another substance which can have equivalent action in the cell.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: March 10, 2015
    Assignees: Amino Up Chemical Co., Ltd, Kansai Medical University
    Inventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
  • Patent number: 8927704
    Abstract: The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: January 6, 2015
    Assignees: Amino Up Chemical Co., Ltd, Kansai Medical University
    Inventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
  • Publication number: 20140037762
    Abstract: Provided is an adiponectin production-promoting agent comprising Botanbouhu as an active component. Such an adiponectin production-promoting agent is able to be used for prevention or treatment of hypoadiponectinemia. Further provided are a pharmaceutical composition, food and drink, and feed comprising such an adiponectin production-promoting agent.
    Type: Application
    Filed: February 14, 2012
    Publication date: February 6, 2014
    Applicants: AMINO UP CHEMICAL CO., LTD.
    Inventors: Kazuhisa Maeda, Yasuo Kamiyama, Toshinori Itou
  • Publication number: 20130303468
    Abstract: Provided are compositions comprising an active ingredient having antispasmodic and/or prokinetic activity, preferably vicenin 2 or biologically active analogues thereof.
    Type: Application
    Filed: November 29, 2012
    Publication date: November 14, 2013
    Applicant: AMINO UP CHEMICAL CO., LTD.
    Inventors: Hajime Fujii, Sybille Buchwald-Werner
  • Publication number: 20130177909
    Abstract: The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or another substance which can have equivalent action in the cell.
    Type: Application
    Filed: February 19, 2013
    Publication date: July 11, 2013
    Applicants: KANSAI MEDICAL UNIVERSITY, AMINO UP CHEMICAL CO., LTD.
    Inventors: Tadayoshi OKUMURA, Mikio NISHIZAWA, Yasuo KAMIYAMA, Koji WAKAME, Takehito MIURA
  • Patent number: 8399424
    Abstract: The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or another substance which can have equivalent action in the cell.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: March 19, 2013
    Assignees: Amino Up Chemical Co., Ltd, Kansai Medical University
    Inventors: Tadayoshi Okumura, Mikio Nishizawa, Yasuo Kamiyama, Koji Wakame, Takehito Miura
  • Patent number: 8088419
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: January 3, 2012
    Assignees: Amino Up Chemical Co., Ltd., Usaien Pharmaceutical Co., Ltd.
    Inventors: Gen-ichiro Nonaka, Buxiang Sun, Lan Yuan, Takashi Nakagawa, Hajime Fujii, Young-Joon Surh
  • Patent number: 7939116
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: May 10, 2011
    Assignees: Amino Up Chemical Co., Ltd., Usaien Pharmaceutical Co., Ltd.
    Inventors: Gen-ichiro Nonaka, Buxiang Sun, Lan Yuan, Takashi Nakagawa, Hajime Fujii, Young-Joon Surh
  • Publication number: 20110065629
    Abstract: The present invention relates to an enteral nutrient for inflammatory bowel disease patients, including an active hexose correlated compound obtained by culturing mycelia of basidiomycetes. The enteral nutrient of the present invention is an enteral nutrient which is expected to exhibit an advantageous effect of AHCC on cancer patients and an action of alleviating inflammation in inflammatory bowel diseases, and to exhibit an action of inhibiting inflammation in patients who are suffering from ulcerative colitis or Crohn's disease and thus have difficulty with oral nutritional intake.
    Type: Application
    Filed: March 17, 2009
    Publication date: March 17, 2011
    Applicant: AMINO UP CHEMICAL CO., LTD.
    Inventor: Keiko Fujikawa
  • Patent number: 7883708
    Abstract: A novel substance that has the physiological activity of the aglycone of isoflavones and the physiological activity of the culture of the basidiomycetes with the physiological activities being synergistically enhanced, obtained by cultivating a basidiomycetes having a ?-glucosidase activity in a medium containing an isoflavone, a method for producing it, and food, feedstuff and medicine containing it. The substance of the invention is improved in the physiological effect of the aglycone of isoflavones and the physiological effect of the culture of the basidiomycetes, and is not only useful as an anti-tumor agent but also is useful for therapy and/or prevention of osteoporosis and also as an immune enhancement agent.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: February 8, 2011
    Assignee: Amino Up Chemical Co., Ltd.
    Inventors: Ken-ichi Kosuna, Lan Yuan, Takehito Miura, Buxiang Sun
  • Publication number: 20110028742
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Application
    Filed: October 6, 2010
    Publication date: February 3, 2011
    Applicants: AMINO UP CHEMICAL CO., LTD., USAIEN PHARMACEUTICAL CO., LTD.
    Inventors: Gen-ichiro NONAKA, Buxiang SUN, Lan YUAN, Takashi NAKAGAWA, Hajime FUJII, Young-Joon SURH