Abstract: Friedelin is a natural compound with promising proprieties. On its own or with chemical modification it is possible to introduce relevant biological activities, e.g., anti-cancer, anti-aging and agrochemical. Its availability in significant amounts has been a major drawback on its regular use and in the pursuit of different applications. Cork and cork-derived materials (e.g., black condensate) are the most relevant sources of Friedelin in nature (up to 10% in concentration). The present invention reports straight-forward procedures to extract and purify Friedelin from cork and cork-derived materials (e.g., black condensate). It uses solvent extraction and (re)crystallization techniques easy to scale up to an industrial level, with a low solvent and low time consumption, high yields, up to 2.9%, and high purity degrees, up to 96%.
Type:
Application
Filed:
December 5, 2008
Publication date:
October 7, 2010
Applicant:
Amorim Revestimentos, S.A.
Inventors:
Ricardo Alexandre Rodrigues Pires, Susana Pinto Araújo da Silva Estima Martins, José António Marchão das Chagas, Rui Luis Gonçalves dos Reis