Patents Assigned to AMORPHICAL LTD.
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Patent number: 11602542Abstract: The present invention provides stabilized amorphous calcium carbonate (ACC) formulations, comprising ACC and a non-aqueous liquid carrier in which the ACC is dispersed. The present invention further provides cosmetic and pharmaceutical compositions comprising ACC.Type: GrantFiled: July 30, 2015Date of Patent: March 14, 2023Assignee: AMORPHICAL LTD.Inventors: Yigal Blum, Yosef Ben, Sharon Hershkovitz
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Patent number: 11446327Abstract: The present invention provides stable amorphous calcium carbonate (ACC) compositions, and food articles comprising said compositions.Type: GrantFiled: July 30, 2015Date of Patent: September 20, 2022Assignee: AMORPHICAL LTD.Inventors: Ali Abo Riziq, Sharon Hershkovitz, Yosef Ben, Yigal Blum
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Patent number: 11207347Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.Type: GrantFiled: July 21, 2020Date of Patent: December 28, 2021Assignee: AMORPHICAL LTD.Inventors: Yosef Ben, Abraham Shahar, Amir Arav
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Patent number: 11052107Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate ((?( (?) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.Type: GrantFiled: June 2, 2016Date of Patent: July 6, 2021Assignee: AMORPHICAL LTD.Inventors: Yosef Ben, Yigal Dov Blum, Hagay Moshe, Ben Ashkenazi
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Patent number: 11052108Abstract: The present invention provides compositions and methods of treating a leukemia, including chronic lymphocytic leukemia, wherein the method comprises administering a stabilized amorphous calcium carbonate to a person in need thereof.Type: GrantFiled: October 23, 2017Date of Patent: July 6, 2021Assignee: AMORPHICAL LTD.Inventor: Yosef Ben
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Patent number: 11033576Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.Type: GrantFiled: July 15, 2020Date of Patent: June 15, 2021Assignee: AMORPHICAL LTD.Inventors: Yosef Ben, Yigal Dov Blum
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Patent number: 10758565Abstract: The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their use in treating ACC-responsive diseases and conditions. Further provided are ACC compositions suitable for buccal or sublingual administration.Type: GrantFiled: June 2, 2016Date of Patent: September 1, 2020Assignee: AMORPHICAL LTD.Inventors: Yosef Ben, Yigal Dov Blum
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Patent number: 10758566Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.Type: GrantFiled: January 17, 2017Date of Patent: September 1, 2020Assignee: AMORPHICAL LTD.Inventors: Yosef Ben, Abraham Shahar, Amir Arav
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Patent number: 10688124Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.Type: GrantFiled: July 31, 2018Date of Patent: June 23, 2020Assignee: AMORPHICAL LTDInventors: Amir Sagi, Assaf Shechter, Galit Shaltiel-Gold, Michal Daniely, Oren Meiron
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Publication number: 20190262391Abstract: The present invention provides compositions and methods of treating a leukemia, including chronic lymphocytic leukemia, wherein the method comprises administering a stabilized amorphous calcium carbonate to a person in need thereof.Type: ApplicationFiled: October 23, 2017Publication date: August 29, 2019Applicant: AMORPHICAL LTD.Inventor: Yosef Ben
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Patent number: 10328100Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.Type: GrantFiled: June 19, 2015Date of Patent: June 25, 2019Assignee: AMORPHICAL LTD.Inventors: Shmuel Bentov, Amir Sagi, Amir Berman, Assaf Shechter
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Patent number: 10125262Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.Type: GrantFiled: December 6, 2016Date of Patent: November 13, 2018Assignee: AMORPHICAL LTD.Inventors: Oren Meiron, Binyamin Ashkenazi
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Patent number: 10064890Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.Type: GrantFiled: December 13, 2012Date of Patent: September 4, 2018Assignee: AMORPHICAL LTD.Inventors: Amir Sagi, Assaf Shechter, Galit Shaltiel-Gold, Michal Daniely, Oren Meiron
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Patent number: 9550878Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.Type: GrantFiled: August 7, 2013Date of Patent: January 24, 2017Assignee: AMORPHICAL LTD.Inventors: Oren Meiron, Binyamin Ashkenazi
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Publication number: 20160045546Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.Type: ApplicationFiled: June 19, 2015Publication date: February 18, 2016Applicant: AMORPHICAL LTD.Inventors: Shmuel BENTOV, Amir SAGI, Amir BERMAN, Assaf SHECHTER
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Patent number: 8802160Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated amino acid which stabilizes the amorphous form of said calcium carbonate. The compositions are useful in pharmaceutical and nutraceutical formulations.Type: GrantFiled: October 22, 2008Date of Patent: August 12, 2014Assignee: Amorphical Ltd.Inventors: Shmuel Bentov, Amir Sagi, Amir Berman, Assaf Shechter
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Publication number: 20100310677Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated amino acid which stabilizes the amorphous form of said calcium carbonate. The compositions are useful in pharmaceutical and nutraceutical formulations.Type: ApplicationFiled: October 22, 2008Publication date: December 9, 2010Applicant: AMORPHICAL LTD.Inventors: Shmuel Bentov, Amir Sagi, Amir Berman, Assaf Shechter
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Publication number: 20100221362Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.Type: ApplicationFiled: April 22, 2010Publication date: September 2, 2010Applicant: AMORPHICAL LTD.Inventors: Shmuel Bentov, Amir Sagi, Amir Berman, Assaf Shechter