Abstract: Product yields in chemical reactions that produce a solid product from a liquid reaction mixture are improved by chromatographically separating certain key impurities from the product mixture prior to crystallization, or from the filtrate after crystallization in which case further product is crystallized from the filtrate. The removal of key impurities either before the first crystallization or between the first and second crystallizations facilitates the crystallization of product to produce a higher yield of product.
Type:
Application
Filed:
July 26, 2011
Publication date:
February 2, 2012
Applicant:
Ampac Fine Chemicals LLC, a California Limited Liability Company
Abstract: R-?-Lipoic acid and its homologs are converted to their magnesium salts in the presence of a reduced form of the acid, dihydro-(+)-lipoic acid in the case of R-?-lipoic acid itself. The reduced form serves as a polymerization inhibitor, resulting in a Mg di-R-?-lipoate product of higher purity. The reduced acid retained in the product tends to convert to the starting acid, thereby avoiding the inclusion of an extraneous polymerization inhibitor in the product.
Type:
Application
Filed:
June 12, 2009
Publication date:
December 16, 2010
Applicant:
Ampac Fine Chemicals LLC, a California Limited Liability Company