Patents Assigned to AMPIO PHARMACEUTICALS, INC.
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Patent number: 11478441Abstract: The invention provides a method, composition and kit for treating T-cell mediated diseases, degenerative joint diseases or diseases mediated by platelet activating factor (PAF) comprising administering to an animal in need thereof, an effective amount a pharmaceutical composition containing N-acetyl-kynurenine (NAK) or pharmaceutically acceptable salts thereof as the active ingredient.Type: GrantFiled: September 17, 2020Date of Patent: October 25, 2022Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, Leonard T. Rael, Raphael Bar-Or
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Patent number: 11369598Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.Type: GrantFiled: October 1, 2020Date of Patent: June 28, 2022Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
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Patent number: 11278598Abstract: The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.Type: GrantFiled: September 22, 2021Date of Patent: March 22, 2022Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, Holli Cherevka
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Patent number: 11129878Abstract: The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.Type: GrantFiled: March 24, 2021Date of Patent: September 28, 2021Assignee: AMPIO PHARMACEUTICALS, INC.Inventors: David Bar-Or, Holli Cherevka
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Patent number: 11090301Abstract: The invention provides a method of treating a joint condition. The method comprises administering a multi-dose regimen of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a method of treating osteoarthritis with multiple doses of a low-molecular weight fraction of human serum albumin.Type: GrantFiled: May 20, 2019Date of Patent: August 17, 2021Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 11058798Abstract: The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).Type: GrantFiled: September 19, 2019Date of Patent: July 13, 2021Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 11026940Abstract: The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.Type: GrantFiled: October 3, 2017Date of Patent: June 8, 2021Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, Greg Thomas
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Patent number: 10881710Abstract: The invention provides a method of treating rhinitis. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP) formulated for nasal administration. The invention also provides a pharmaceutical product comprising a DA-DKP containing composition.Type: GrantFiled: October 26, 2012Date of Patent: January 5, 2021Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 10842847Abstract: The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.Type: GrantFiled: February 19, 2019Date of Patent: November 24, 2020Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, James V. Winkler
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Patent number: 10828296Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.Type: GrantFiled: October 2, 2019Date of Patent: November 10, 2020Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
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Patent number: 10471178Abstract: The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).Type: GrantFiled: February 14, 2018Date of Patent: November 12, 2019Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 10342793Abstract: The invention provides a method of treating a joint condition. The method comprises administering a multi-dose regimen of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a method of treating osteoarthritis with multiple doses of a low-molecular weight fraction of human serum albumin.Type: GrantFiled: March 22, 2018Date of Patent: July 9, 2019Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 10251930Abstract: The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.Type: GrantFiled: March 8, 2017Date of Patent: April 9, 2019Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, James V. Winkler
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Publication number: 20190022087Abstract: The invention provides a method of treating a joint condition. The method comprises administering a multi-dose regimen of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a method of treating osteoarthritis with multiple doses of a low-molecular weight fraction of human serum albumin.Type: ApplicationFiled: March 22, 2018Publication date: January 24, 2019Applicant: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 10058562Abstract: The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a vascular-hyperpermeability-inhibiting amount of a danazol compound to the animal. The method comprises administering an effective amount of a danazol compound to the animal accounting for the body fat content of the animal. The invention also provides a method of modulating the cytoskeleton of an endothelial cell in an animal.Type: GrantFiled: April 27, 2016Date of Patent: August 28, 2018Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 10039760Abstract: The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.Type: GrantFiled: December 21, 2016Date of Patent: August 7, 2018Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, C. Gerald Curtis, Nagaraja K. R. Rao, Greg Thomas
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Patent number: 9987292Abstract: The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a vascular-hyperpermeability-inhibiting amount of a danazol compound to the animal. The invention also provides a method of modulating the cytoskeleton of an endothelial cell in an animal. The method comprises administering an effective amount of a danazol compound to the animal.Type: GrantFiled: December 2, 2015Date of Patent: June 5, 2018Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 9956217Abstract: The invention provides a method of treating a joint condition. The method comprises administering a multi-dose regimen of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a method of treating osteoarthritis with multiple doses of a low-molecular weight fraction of human serum albumin.Type: GrantFiled: August 18, 2015Date of Patent: May 1, 2018Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 9925300Abstract: The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).Type: GrantFiled: October 10, 2012Date of Patent: March 27, 2018Assignee: Ampio Pharmaceuticals, Inc.Inventor: David Bar-Or
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Patent number: 9808454Abstract: The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.Type: GrantFiled: March 17, 2014Date of Patent: November 7, 2017Assignee: Ampio Pharmaceuticals, Inc.Inventors: David Bar-Or, Greg Thomas