Abstract: Described herein are cocrystals of epigallocatechin gallate (ECGC) and caffeine, compositions comprising such cocrystals, methods of making such cocrystals, and methods of improving animal or human health by treating with such cocrystals. In particular, Form I and Form II of a 1:2 (epigallocatechin gallate to caffeine) cocrystal are described.
Type:
Grant
Filed:
September 1, 2016
Date of Patent:
October 27, 2020
Assignee:
AMRI SSCI, LLC
Inventors:
Shital Viral Mehta, Jing Teng, Jon Selbo
Abstract: Disclosed herein are cocrystals of p-coumaric acid and nicotinamide. A 1:1 molar ratio and a 2:1 molar ratio of p-coumaric acid to nicotinamide are herein disclosed.
Abstract: Polymorphs, Forms II and III, of cocrystals of p-coumaric acid and nicotinamide in a 1:1 molar ratio. Pharmaceutical compositions containing Forms II or III, processes for making such forms, and methods of treatment with such Forms.
Abstract: The present invention relates to a cocrystal of progesterone and a coformer selected from the group consisting of vanillic acid, benzoic acid, salicylic acid, cinnamic acid, and vanillin. The present invention also relates to a pharmaceutical composition comprising a cocrystal of the present invention and at least one pharmaceutically acceptable carrier. The present invention further relates to a method of supplementing progesterone in women. This method involves administering to a female subject in need thereof a pharmaceutical composition of the present invention.
Type:
Grant
Filed:
October 25, 2016
Date of Patent:
May 29, 2018
Assignee:
AMRI SSCI, LLC
Inventors:
Ekaterina Albert, Patricia Andres, Melanie Janelle Bevill, Jared Smit, Jennifer Nelson
Abstract: Disclosed herein are cocrystals of progesterone and a coformer containing a six-membered aromatic ring having at least one substituent possessing a carbonyl functionality. Cocrystals of progesterone and a coformer selected from vanillic acid, benzoic acid, salicylic acid, cinnamic acid, or vanillin are also disclosed herein.
Type:
Grant
Filed:
September 4, 2013
Date of Patent:
December 6, 2016
Assignee:
AMRI SSCI, LLC
Inventors:
Ekaterina Albert, Patricia Andres, Melanie Janelle Bevill, Jared Smit, Jennifer Nelson
Abstract: Polymorphs, Forms II and III, of cocrystals of p-coumaric acid and nicotinamide in a 1:1 molar ratio. Pharmaceutical compositions containing Forms II or III, processes for making such forms, and methods of treatment with such Forms.
Abstract: Disclosed are processes for preparing cocrystals, including processes for scaling up of cocrystal formation, as well as scalable processes for preparing cocrystals. Also disclosed are processes for scaled-op preparation of pterostilbene, progesterone, p-coumaric, and minoxidil cocrystals. Minoxidil cocrystals, such as minoxidil:benzoic acid 1:1 monohydrate cocrystals are also disclosed herein.
Type:
Application
Filed:
August 10, 2015
Publication date:
April 7, 2016
Applicant:
AMRI SSCI, LLC
Inventors:
Melanie Janelle Bevill, Christopher Scott Seadeek, Ekaterina V. Albert, Petinka I. Vlahova, Richard James Ely, Patricia Andres
Abstract: Disclosed are processes for preparing cocrystals, including processes for scaling up of cocrystal formation, as well as scalable processes for preparing cocrystals. Also disclosed are processes for scaled-up preparation of pterostilbene, progesterone, p-coumaric, and minoxidil cocrystals. Minoxidil cocrystals, such as minoxidil:benzoic acid 1:1 monohydrate cocrystals are also disclosed herein.
Type:
Grant
Filed:
October 22, 2012
Date of Patent:
September 1, 2015
Assignee:
AMRI SSCI, LLC
Inventors:
Melanie Janelle Bevill, Christopher Scott Seadeek, Ekaterina V. Albert, Petinka I. Vlahova, Richard James Ely, Patricia Andres