Patents Assigned to Amsilk GmbH
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Patent number: 11827678Abstract: The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.Type: GrantFiled: July 23, 2021Date of Patent: November 28, 2023Assignees: Amsilk GmbH, Ludwig-Maximilians-Universitat Munchen, Universitat BayreuthInventors: Lin Romer, Ute Slotta, Julia Engert, Gerhard Winter, Matthias Lucke, Thomas Scheibel
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Patent number: 11667683Abstract: The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.Type: GrantFiled: April 30, 2021Date of Patent: June 6, 2023Assignees: Amsilk GmbH, Ludwig-Maximilians-Universitat Munchen, Universitat BayreuthInventors: Lin Romer, Ute Slotta, Julia Engert, Gerhard Winter, Matthias Lucke, Thomas Scheibel
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Patent number: 11324852Abstract: The present invention relates to coated silk films. Further, the present invention relates to pharmaceutical or cosmetic compositions comprising the coated silk films. Furthermore, the present invention relates to coated silk films or pharmaceutical compositions comprising the coated silk films for use in medicine. In addition, the present invention relates to methods of producing the coated silk films.Type: GrantFiled: January 29, 2015Date of Patent: May 10, 2022Assignee: Amsilk GmbHInventors: Gerhard Winter, Elisa Agostini, Julia Engert, Lin Romer, Ute Slotta
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Patent number: 11273234Abstract: The present invention relates to a self-assembling polypeptide, such as a spider silk polypeptide, for use as a coating material to form a uniform coating around an implant for the purpose of reducing or preventing capsular fibrosis associated with the use of such an implant in the human body.Type: GrantFiled: October 11, 2019Date of Patent: March 15, 2022Assignee: Amsilk GmbHInventors: Axel Leimer, Lin Romer, Nathalie Maksimovikj
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Patent number: 11248120Abstract: The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution.Type: GrantFiled: September 10, 2018Date of Patent: February 15, 2022Assignee: Amsilk GmbHInventors: Thomas Scheibel, Axel Leimer, Lin Römer, Lukas Eisoldt, Aniela Heidebrecht, Martha Geffers
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Patent number: 11104708Abstract: The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.Type: GrantFiled: June 13, 2017Date of Patent: August 31, 2021Assignees: Amsilk GmbH, Ludwig-Maximilians-Universitat Munchen, Universitat BayreuthInventors: Lin Romer, Ute Slotta, Julia Engert, Gerhard Winter, Matthias Lucke, Thomas Scheibel
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Patent number: 10721928Abstract: The present invention relates to the use of a biopolymer for reducing the formation of a biofilm, preferably on a substrate, whereby the biopolymer is preferably a polypeptide, such as recombinant spider silk polypeptide. The present invention further relates to methods for producing a substrate which reduces the formation of a biofilm on a surface of said substrate.Type: GrantFiled: October 11, 2016Date of Patent: July 28, 2020Assignee: Amsilk GmbHInventors: Jens Klein, Lin Romer, Thomas Scheibel, Ute Slotta
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Patent number: 10478520Abstract: The present invention relates to a self-assembling polypeptide for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair.Type: GrantFiled: August 14, 2013Date of Patent: November 19, 2019Assignee: Amsilk GmbHInventors: Axel Leimer, Lin Römer, Nathalie Maksimovikj
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Patent number: 10253213Abstract: The present invention relates to a method for coating an inert or naturally occurring material with a silk polypeptide. It further relates to a coated inert or naturally occurring material obtainable by said method and to uses thereof. It also relates to products comprising said coated material.Type: GrantFiled: December 3, 2015Date of Patent: April 9, 2019Assignee: Amsilk GmbHInventors: Axel H. Leimer, Lin Romer
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Publication number: 20190062557Abstract: The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution.Type: ApplicationFiled: September 10, 2018Publication date: February 28, 2019Applicant: Amsilk GmbHInventors: Thomas Scheibel, Axel Leimer, Lin Römer, Lukas Eisoldt, Aniela Heidebrecht, Martha Geffers
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Patent number: 10072152Abstract: The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibers, the thus produced silk protein spinning dope solution, methods for producing fibers using said silk protein spinning dope solution.Type: GrantFiled: September 5, 2013Date of Patent: September 11, 2018Assignee: AMSILK GMBHInventors: Thomas Scheibel, Axel Leimer, Lin Römer, Lukas Eisoldt, Aniela Heidebrecht, Martha Geffers
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Patent number: 9233067Abstract: The present invention relates to a method of producing and loading silk particles, preferably spider silk particles, with a compound. In particular, the present invention provides a novel two step method for loading silk particles, preferably spider silk particles, with small and water-soluble compounds. Also disclosed are silk particles, preferably spider silk particles, loaded with at least one compound which are eminently suited as carriers for controlled and sustained delivery applications. Furthermore, the invention relates to pharmaceutical or cosmetic compositions comprising said silk particles, preferably spider silk particles, and a pharmaceutically active compound or cosmetic compound for controlled and sustained release. The present invention is also directed to silk particles, preferably spider silk particles, loaded with a compound obtainable by the method according to the invention.Type: GrantFiled: November 30, 2010Date of Patent: January 12, 2016Assignee: Amsilk GmbHInventors: Andreas Lammel, Thomas Scheibel, Martin Schwab, Gerhard Winter, Markus Hofer, Julia Myschik
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Patent number: 9217017Abstract: The present invention relates to a method for coating an inert or naturally occurring material with a silk polypeptide. It further relates to a coated inert or naturally occurring material obtainable by said method and to uses thereof. It also relates to products comprising said coated material.Type: GrantFiled: December 7, 2010Date of Patent: December 22, 2015Assignee: Amsilk GmbHInventors: Axel H. Leimer, Lin Romer
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Publication number: 20150284565Abstract: The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution.Type: ApplicationFiled: September 5, 2013Publication date: October 8, 2015Applicant: Amsilk GmbHInventors: Thomas Scheibel, Axel Leimer, Lin Römer, Lukas Eisoldt, Aniela Heidebrecht, Martha Geffers
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Patent number: 9034816Abstract: The present invention relates to a biopolymer having excellent tensile strength, extensibility and toughness. The present invention further relates to a nucleic acid molecule encoding the biopolymer of the invention, a vector comprising the nucleic acid molecule of the invention and a non-human host transformed with the vector of the invention. Furthermore, the present invention relates to methods for producing a biopolymer of the invention and to foams, films, gels, coatings, particles, capsules, springs or nonwoven mats as well as fibers comprising or consisting of the biopolymer of the invention. The present invention also relates to a method of producing fibers and the biopolymer of the invention for use in medicine, agriculture, cosmetics as well as surface, paper, leather and/or textile processing.Type: GrantFiled: January 16, 2013Date of Patent: May 19, 2015Assignee: AMSilk GmbHInventors: Thomas Scheibel, Felix Bauer
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Patent number: 8877903Abstract: The present invention relates to a method of isolating an insoluble target protein from a suspension of intact or disrupted host cells. The invention also relates to insoluble target proteins which are obtainable by said method, in particular to silk proteins.Type: GrantFiled: March 30, 2011Date of Patent: November 4, 2014Assignee: Amsilk GmbHInventors: Martin Schmidt, Axel Lelmer, Lin Römer
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Patent number: 8729238Abstract: The present invention is directed to a method of producing nano- and microcapsules from spider silk proteins The invention is further directed to nano- or microcapsules obtainable by this method as well as pharmaceutical, cosmetical and food compositions containing same.Type: GrantFiled: December 27, 2012Date of Patent: May 20, 2014Assignee: Amsilk GmbHInventors: Thomas Scheibel, Daniel Huemmerich, Andreas Bausch, Kevin Hermanson
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Patent number: 8721991Abstract: The present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly of the said silk protein(s) to defined morphologies, such as spheres, nano fibrils, threads, etc.Type: GrantFiled: May 21, 2007Date of Patent: May 13, 2014Assignee: AMSilk GmbHInventors: Thomas Scheibel, Daniel Huemmerich, Sebastian Remmensee, Christian Freudiger, Andreas Bausch
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Publication number: 20130225476Abstract: The present invention relates to a biopolymer having excellent tensile strength, extensibility and toughness. The present invention further relates to a nucleic acid molecule encoding the biopolymer of the invention, a vector comprising the nucleic acid molecule of the invention and a non-human host transformed with the vector of the invention. Furthermore, the present invention relates to methods for producing a biopolymer of the invention and to foams, films, gels, coatings, particles, capsules, springs or nonwoven mats as well as fibres comprising or consisting of the biopolymer of the invention. The present invention also relates to a method of producing fibres and the biopolymer of the invention for use in medicine, agriculture, cosmetics as well as surface, paper, leather and/or textile processing.Type: ApplicationFiled: January 16, 2013Publication date: August 29, 2013Applicant: AMSilk GmbHInventor: AMSilk GmbH
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Publication number: 20130172478Abstract: The present invention relates to a method of spinning a polypeptide polymer containing fibre. It further relates to a polymer fibre obtainable by said method and to uses thereof. The invention also relates to products comprising said polymer fibre.Type: ApplicationFiled: March 16, 2011Publication date: July 4, 2013Applicant: AMSILK GMBHInventors: Andreas Bausch, Sebastian Rammensee