Patents Assigned to Amura Therapeutics Ltd.
  • INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES
    Publication number: 20090247471
    Abstract: Compounds of general formula (I) or general formula (II):— wherein R1, P1, P2, Q, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.
    Type: Application
    Filed: September 15, 2008
    Publication date: October 1, 2009
    Applicant: Amura Therapeutics Ltd.
    Inventor: Martin Quibell
  • Preparation of diazapentalene derivatives via epoxydation of dihydropyrroles
    Publication number: 20090005575
    Abstract: The present invention relates to a process for preparing a compound of formula I, wherein R1 is Pg1 or P1?; P1? is CO-hydrocarbyl; P2 is CH2, O or N-Pg2; and Pg1 and Pg2 are each independently nitrogen protecting groups; (i) reacting a compound of formula II with a dioxirane to form an epoxide of formula III; where X is selected from CN, CH2N3, CH2NH-Pg2, ONH-Pg2, NHNH-Pg2, N(Pg2)NH-Pg2; (ii) converting a compound of formula III to a compound of formula I
    Type: Application
    Filed: February 8, 2008
    Publication date: January 1, 2009
    Applicant: Amura Therapeutics Ltd.
    Inventors: Martin Quibell, Yikang Wang, James Nally, John Paul Watts, Virendar Kumar Agrawal, Michael Standen
  • Inhibitors of cruzipain and other cysteine proteases
    Patent number: 7425562
    Abstract: Compounds of general formula (I) or general formula (II) wherein R1, P1, P2, Q, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: September 16, 2008
    Assignee: Amura Therapeutics Ltd.
    Inventor: Martin Quibell