Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
Type:
Grant
Filed:
May 2, 2018
Date of Patent:
August 6, 2019
Assignees:
The Regents of the University of California, Amydis Diagnostics, Inc.
Inventors:
Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf