Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
Type:
Grant
Filed:
February 9, 2021
Date of Patent:
August 8, 2023
Assignees:
The Regents of the University of California, Amydis, Inc.
Inventors:
Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
Type:
Grant
Filed:
June 12, 2019
Date of Patent:
March 2, 2021
Assignees:
The Regents of the University of California, Amydis, Inc.
Inventors:
Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the methods for treating of diseases associated with an amyloid or amyloid like proteins.
Type:
Grant
Filed:
March 19, 2015
Date of Patent:
June 26, 2018
Assignees:
The Regents Of The University Of California, Amydis, Inc.
Inventors:
Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
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