Patents Assigned to An2H Discovery Limited
  • PYRAZOLOPYRIMIDINE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME
    Publication number: 20200317674
    Abstract: The present disclosure is directed to pyrazolo[1,5-a]pyrimidine compounds of formula (I), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase. R21, R22, R23, R24 and R25 are as defined herein.
    Type: Application
    Filed: June 5, 2017
    Publication date: October 8, 2020
    Applicants: An2H Discovery Limited, An2H Discovery Limited
    Inventors: Jennifer JOHNSTON, Albert W. GAROFALO, Paul Ross FATHEREE
  • Triazole benzamide derivatives and the compositions and methods of treatment regarding the same
    Patent number: 10308617
    Abstract: The present disclosure is directed to triazole benzamide compounds of formula (I) and formula (II), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase. R1, R2, R3, M1, M2, M3, L1, L2, and L3 are as defined herein.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: June 4, 2019
    Assignee: AN2H DISCOVERY LIMITED
    Inventors: Jennifer Johnston, Albert W. Garofalo, Paul Ross Fatheree
  • Parkin ligase activation methods and compositions
    Patent number: 10155936
    Abstract: The present invention is directed to methods and compositions for activating a Parkin ligase by administering to a subject in need thereof a therapeutically effective amount of a compound that disrupts at least one Parkin ligase zinc finger. The present invention is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: December 18, 2018
    Assignee: AN2H DISCOVERY LIMITED
    Inventor: Jennifer Johnston
  • PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS
    Publication number: 20160160205
    Abstract: The present invention is directed to methods and compositions for activating a Parkin ligase by administering to a subject in need thereof a therapeutically effective amount of a compound that disrupts at least one Parkin ligase zinc finger. The present invention is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase.
    Type: Application
    Filed: December 7, 2015
    Publication date: June 9, 2016
    Applicant: An2H Discovery Limited
    Inventor: Jennifer Johnston