Abstract: Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
Type:
Application
Filed:
May 2, 2007
Publication date:
November 15, 2007
Applicant:
Anacor Pharmaceuticals
Inventors:
Ving Lee, Jacob Plattner, Stephen Benkovic, Stephen Baker, Kirk Maples, Carolyn Bellinger-Kawahara, Tsutomu Akama, Yong-Kang Zhang, Rajeshwar Singh, Vittorio Sauro
Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
Type:
Application
Filed:
August 16, 2006
Publication date:
July 5, 2007
Applicant:
Anacor Pharmaceuticals
Inventors:
Stephen Baker, Tsutomu Akama, Michael Alley, Steven Benkovic, Michael DiPierro, Vincent Hernandez, Karin Hold, Isaac Kennedy, Igor Likhotvorik, Weimin Mao, Kirk Maples, Jacob Plattner, Fernando Rock, Virginia Sanders, Aaron Stemphoski, George Yiannikouros, Siead Zegar, Yong-Kang Zhang, Huchen Zhou
Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
Type:
Application
Filed:
February 16, 2006
Publication date:
October 19, 2006
Applicant:
Anacor Pharmaceuticals
Inventors:
Stephen Baker, Tsutomu Akama, Carolyn Bellinger-Kawahara, Vincent Hernandez, Karin Hold, James Leyden, Kirk Maples, Jacob Plattner, Virginia Sanders, Yong-Kang Zhang