Patents Assigned to ANADYS Pharmaceuticals, Inc.
  • 1-METHYL-BENZO[1,2,4]THIADIAZINE 1-OXIDE DERIVATIVES
    Publication number: 20080292588
    Abstract: The invention is directed to 1-methyl-benzo[1,2,4]thiadiazine 1-oxide derivatives and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: May 16, 2008
    Publication date: November 27, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Yuefen Zhou, Thomas Bertolini, Liansheng Li
  • 3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF
    Publication number: 20080255063
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: January 17, 2008
    Publication date: October 16, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averet, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden, David Louis Clark, Alan X. Xiang
  • Pyridazinone compounds
    Patent number: 7425552
    Abstract: The invention is directed to pyridazinone compounds of Formula I and pharmaceutical compositions containing compounds of Formula I wherein R1 and R2 are independently H, alkyl, cycloalkyl, aryl, or heterocyclyl; and Ring A is 5 or 6-membered aryl or heterocyclyl. The invention also encompasses methods of using a compound of Formula I in the treatment of hepatitis C virus infections.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: September 16, 2008
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Yuefen Zhou, Liansheng Li, Stephen E. Webber
  • PYRIDAZINONE COMPOUNDS
    Publication number: 20080188466
    Abstract: The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: September 26, 2007
    Publication date: August 7, 2008
    Applicant: ANADYS PHARMACEUTICALS, INC.
    Inventors: Peter Dragovich, Yuefen Zhou, Stephen E. Webber
  • 3-beta-D-Ribofuranosylthiazalo [4-5-d] pyrimidine nucleosides and uses thereof
    Publication number: 20080090844
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: February 22, 2007
    Publication date: April 17, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Devron Averett, Stephen Webber, Joseph Lennox, Erik Rueden
  • PYRIDAZINONE COMPOUNDS
    Publication number: 20080090814
    Abstract: The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: June 21, 2007
    Publication date: April 17, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: David Ellis, Stephen Webber, Yuefen Zhou, Peter Dragovich
  • PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS
    Publication number: 20080031852
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: June 21, 2007
    Publication date: February 7, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas Murphy, David Kucera, Zhongxiang Sun, Chinh Tran
  • Prodrugs of 5-amino-3-(3'-deoxy-b-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
    Publication number: 20080032999
    Abstract: The invention is directed to 5-amino-3-(3?-deoxy-?-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione prodrugs, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
    Type: Application
    Filed: June 21, 2007
    Publication date: February 7, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Gregory Haley, Joseph Lennox, Alan Xiang, Stephen Webber
  • CARBONATE AND CARBAMATE PRODRUGS OF THIAZOLO[4,5-d]PYRIMIDINES
    Publication number: 20080020989
    Abstract: The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
    Type: Application
    Filed: July 17, 2007
    Publication date: January 24, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Gregory Haley, Joseph Lennox, Alan Xiang, Stephen Webber
  • 3-B-D-ribofuranosylthiazolo [4,5-] pyrimidine nucleosides and uses thereof
    Patent number: 7321033
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: January 22, 2008
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden, David Louis Clark, Alan Xin Xiang
  • Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
    Publication number: 20070197533
    Abstract: The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammals, especially humans.
    Type: Application
    Filed: April 12, 2007
    Publication date: August 23, 2007
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Yuefen Zhou, Dionisios Vourloumis, Vlad Gregor, Geoffrey Winters, Thomas Hermann, Benjamin Ayida, Zhongxiang Sun, Douglas Murphy, Klaus Simonsen
  • Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
    Patent number: 7223759
    Abstract: The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammals, especially humans.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: May 29, 2007
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Yuefen Zhou, Dionisios Vourloumis, Vlad E. Gregor, Geoffrey C. Winters, Thomas Hermann, Benjamin Ayida, Zhongxiang Sun, Douglas Murphy, Klaus B. Simonsen
  • Novel process for the preparation of 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-one
    Publication number: 20070117979
    Abstract: The present invention relates to a process for the preparation of the title compound, 5-amino-3H-thiazolo[4,5-d]pyrimidin-2-one, which is a useful intermediate in the preparation of certain thiazolo[4,5-d]pyrimidine nucleosides, which can have utility as immunomodulators.
    Type: Application
    Filed: November 20, 2006
    Publication date: May 24, 2007
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Tingman Wang, John Ng, Stephen Webber
  • Pyridazinone compounds
    Publication number: 20060189602
    Abstract: The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: December 16, 2005
    Publication date: August 24, 2006
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Yuefen Zhou, Liansheng Li, Stephen Webber
  • 3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
    Publication number: 20060160830
    Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
    Type: Application
    Filed: December 16, 2005
    Publication date: July 20, 2006
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen Webber, Gregory Haley, Joseph Lennox, Alan Xiang, Erik Rueden
  • Hepatitis C virus constructs characterized by high efficiency replication
    Publication number: 20050260221
    Abstract: The present invention relates to recombinant hepatitis C virus (HCV)-derived nucleic acids and to stable rapidly growing cell clones derived from human hepatoma Huh-7 cell line and supporting high titer replication of said recombinant HCV nucleic acids. The subgenomic HCV replicons and cell clones of the instant invention represent the in vitro system of choice for studies of HCV propagation, anti-viral drug screening, and vaccine development.
    Type: Application
    Filed: April 20, 2005
    Publication date: November 24, 2005
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Vadim Bichko, Victor Shifrin, Svetlana Bergelson
  • 3-beta-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and uses thereof
    Publication number: 20050182001
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: March 16, 2005
    Publication date: August 18, 2005
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Devron Averett, Stephen Webber, Joseph Lennox, Erik Rueden
  • Hepatitis C virus constructs characterized by high efficiency replication
    Patent number: 6930095
    Abstract: The present invention relates to recombinant hepatitis C virus (HCV)-derived nucleic acids and to stable rapidly growing cell clones derived from human hepatoma Huh-7 cell line and supporting high titer replication of said recombinant HCV nucleic acids. The subgenomic HCV replicons and cell clones of the instant invention represent the in vitro system of choice for studies of HCV propagation, anti-viral drug screening, and vaccine development.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: August 16, 2005
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventor: Vadim Bichko
  • 3-?-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof
    Patent number: 6924271
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: August 2, 2005
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden
  • Heterocyclic compounds for treating hepatitis C virus
    Publication number: 20050075375
    Abstract: The invention is directed to heterocyclic compounds and pharmaceutical compositions of the same for treating Hepatitis C virus.
    Type: Application
    Filed: May 14, 2004
    Publication date: April 7, 2005
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Dionisios Vourloumis, Masayuki Takahashi, Geoffrey Winters, Jinglan Zhou, Russell Duchene