Abstract: The present disclosure relates to a device for filtering at least one selected ion from an ion beam includes a unit for creating an electric field for accelerating the ions of the ion beam along a flight path of predefinable length, and a controllable ion optical system, which delimits the flight path in one direction, and which is used to deflect the selected ion from a flight path of the ion beam. The device is further designed to control the ion optical system subject to a flight time of the selected ion along the flight path. The present disclosure also relates to a mass spectrometer having a device according to the present disclosure, and to a method for filtering at least one selected ion from an ion beam.

Abstract: The present disclosure includes a method for determining the necessity of a measure and/or the success of a measure in the case of a sensor in a retractable assembly, comprising the steps: moving the sensor in the direction of a service chamber of the retractable assembly; analyzing an attribute associated with the sensor, wherein the attribute is a state of at least a portion of the surface of the sensor and/or composition of a medium in the service chamber; and deriving measures from the analysis. The present disclosure also includes a system comprising a retractable assembly having a sensor and a corresponding analysis device.

Abstract: The present disclosure relates to a combustion tube for a device for elemental analysis of a sample, comprising an outer tube including an outlet and an inner tube including an inlet, the inner tube detachably insertable into the outer tube, wherein the outer and inner tubes are arranged such that the sample passes through the inlet, through the inner tube into the outer tube, and out of the combustion tube through the outlet, wherein the inner and outer tubes are configured such that, at least in a region in which the inner tube is surrounded by the outer tube, the sample is essentially inside the inner tube. The outer tube is made of a quartz glass, and the inner tube is made of a ceramic. The present invention further relates to a device for elemental analysis of a sample comprising a combustion tube according to the present disclosure.

Abstract: An analytical device for determining a measured variable dependent on the concentration of one or more constituents of a sample includes a decomposition reactor surrounded by an insulating tube, a heating apparatus, an oxygen production system including at least one oxygen permeable membrane, a housing, and a feed gas guiding system for supplying a feed gas to the at least one membrane of the oxygen production system. The feed gas guiding system includes a reaction space surrounding the at least one membrane and is connected with an inflow duct open to the environment such that at least two partitions are arranged coaxially within the insulating tube and surrounding the decomposition reactor, where the partitions subdivide an intermediate space arranged between the decomposition reactor and the insulating tube into annular chambers forming the feed gas guiding system, where the annular chambers are connected with one another by overflow openings.

Abstract: The invention relates to an analysis device for determining a measurement variable based on the concentration of one or more contents of a sample, comprising: a digestion reactor with a gas inlet and a gas outlet; a measuring device which is connected to the gas outlet of the digestion reactor; a control and analysis device which is designed to receive and process measurement values that are registered by the measuring device and are based on the measurement variable; an oxygen generating device; and a gas line system which connects the oxygen generating device to the gas inlets of the digestion reactor in order to supply oxygen generated by the oxygen generating device to the digestion reactor, wherein the gas line system comprises a gas storage device which has at least one chamber with a variable volume for receiving an oxygen quantity to be stored.

Abstract: A temperature-control device for receiving a reaction vessel having a heat-insulated interior space and which is covered by a lid. The reaction vessel has a hollow body and a cap, this hollow body being closed on one side by a base. The base contacts a heatable heating block in order to heat a sample located in the reaction vessel. The hollow body is surrounded by a heatable heating body which communicates with the lid via a heat-conducting contact region so that the heating body heats the hollow body directly and heats the cap indirectly via the lid.

Abstract: A method for the determination and correction of background signals in a spectrum, consisting of signals of a plurality of spectral points, characterized by the steps of: Calculating at least three statistic or analytic functions of the signal values of the spectrum, attributing probabilities Pi(band) for the presence of bands to each point in each of the calculated functions: Adding the probabilities Pi(band) up to an overall probability ?Pi(band) from all calculated functions for each point; calculating a probability P(background) for the presence of background for each point in the spectrum from said overall probability ?Pi(band) according to P(background)=1??Pi(band) wherein negative values are set to zero; and calculating a fit of the signal values at all points of the original spectrum wherein the signal in each point is taken into account in the fit only with the respective probability for the presence of background P(background), and subtraction of the background function determined in such a way from

Abstract: The present disclosure resides in a spectrometer arrangement including a first dispersing element for spectral separation of radiation in a main dispersion direction, and a second dispersing element for spectral separation of radiation in a cross-dispersion direction, which is at an angle to the main dispersion direction, so that a two-dimensional spectrum is producible. The spectrometer arrangement also includes a collimating optics, which directs collimated radiation to the first and/or second dispersing element, a camera optics, which images a two-dimensional spectrum in an image plane, a two-dimensional detector for detecting the two-dimensional spectrum in the image plane, and an off-axis section of a rotationally symmetric, refractive element, which is arranged between the camera optics and the detector. The present disclosure resides likewise in an optical module comprising such a spectrometer arrangement.

Abstract: The present disclosure discloses a spectrometer arrangement including an entrance-slit group including a slit wheel and a slit mask for introducing radiation into and for limiting the optical field of the spectrometer arrangement, a first dispersive element for spectrally decomposing the radiation in a main dispersion direction, and a second dispersive element for spectrally decomposing the radiation in a transverse dispersion direction that forms an angle with the main dispersion direction to yield a two-dimensional spectrum. The slit wheel is mounted rotatably about an axis of rotation and has a falcate opening having a width that changes depending on the angle. The slit mask includes an opening that is longer than a largest width of the falcate opening such that radiation radiates through the falcate opening of the slit wheel and the opening of the slit mask. The present disclosure further includes a corresponding method and an optical component group.

Abstract: A spectrometer arrangement with two-dimensional spectrum, comprising a first dispersing element for spectral separation of radiation in a main dispersion direction, an imaging optics for imaging the radiation entering into the spectrometer arrangement through an entrance slit in an image plane for producing a two-dimensional spectrum, and a detector array with a two-dimensional arrangement of a plurality of detector elements in the image plane, wherein a reflector, a refractor, and/or a lens array are arranged in the beam path at a location where the dispersed, monochromatic beams are separated from one another, and the reflector, the refractor, and/or the lens array have a surface in the form of a freeform surface, such that area occupied by selected images of the entrance slit in the case of different wavelengths in the image plane is optimized over a selected spectral region of the two-dimensional spectrum.

Abstract: A method for the spectral analysis of samples in a graphite tube, comprising the steps of: inserting a liquid sample into a graphite tube; drying the sample by heating the graphite tube; transferring the sample into a particle cloud by further heating up the graphite tube; and measuring one of the optical signals influenced or generated by the sample with a detector; wherein image sequences of the interior of the graphite tube are recorded with a two-dimensional camera having a plurality of image elements over selected periods of time during the spectral analysis; is characterized in that the images of the image sequences are automatically processed with image processing methods, wherein a reference image of the interior of the graphite tube is determined; and the condition of the graphite tube, of the sample and/or of a dosing means for inserting the sample into the graphite tube is determined by comparison of the images of the image sequences to the reference image.

Abstract: Cuvette, comprising a first flat plate (1) and a second flat plate (2), both of which in a closed state of the cuvette are positioned so as to be situated opposite parallel to each other and at which there is at least one transparent first measuring surface (1.1) and at least one transparent second measuring surface (2.1), which define in pairs a measuring space (3), in which a liquid sample solution having a drop volume can be held by means of its surface tension and capillary forces. At least the second measuring surface (2.1) of each one of the measuring spaces (3) is a stepped surface, which has at least two plane-parallel partial measuring surfaces (2.1.1, 2.1.2), which are connected to each other by means of a setting surface (2.1.0), so that the partial measuring surfaces (2.1.1, 2.1.2) exhibit different vertical distances (b1, b2) from the first measuring surface (1.1).

Abstract: A cold box having a cooling receptacle filled with a dry protective gas in which is accommodated a rack loaded with tube-shaped vessels. The cooling receptacle is covered by a movable lid which is associated with a lid part and which is preferably formed by an outer lid and a rotatable inner lid integrated in the outer lid so that the cooling receptacle is completely covered in every position of the lid. At least one of the through-holes provided in the inner lid can be arranged over a respective tube-shaped vessel by a coordinated movement of the outer lid and rotation of the inner lid so that the tube-shaped vessel located under the through-hole in alignment therewith can be filled with a sample through the through-hole by means of a commercially available pipette tip/dispensing needle of an automated pipetting device.

Abstract: There is provided a sampling interface for use with a mass spectrometry apparatus. The sampling interface is arranged so as to enable the sampling of ions in a mass spectrometer. In one aspect, the sampling interface comprises an inlet for receiving a quantity of ions from an ion source, and a region downstream of the inlet for accommodating a gas through which the ions may pass, wherein a field having a selected bias voltage potential is provided in at least a portion of the downstream region through which the ions may pass.

Abstract: A heating and magnet module for a device for the purpose of purifying nucleic acids, having a plate assembly which has a heating plate, and a magnet carrier plate. The heating plate and the magnet carrier plate can be moved vertically relative to each other between two end positions, in opposition to a spring force. A vessel arrangement is placed on the heating plate, having row or matrix form vessels. One magnet of the magnet carrier plate is functionally assigned to each of these.

Abstract: A pipetting apparatus includes a pipetting head with a plurality of pipetting channels disposed in an arrangement pattern. Each pipetting channel includes a plunger and a cylinder. The plurality of pipetting channels includes at least two groups of pipetting channels with different diameters including a group of larger pipetting channels and a group of smaller pipetting channels. Each of the at least two groups of pipetting channels is disposed in an arrangement pattern in the pipetting head. Larger pipette tips communicate with the group of larger pipetting channels or smaller pipette tips communicate with the group of smaller pipetting channels.

Abstract: There is provided a mass spectrometry apparatus comprising: an ion source arranged in a substantially horizontal orientation and from which a quantity of ions may be sourced, an ion filter device arranged for receiving a stream of ions for filtering thereof; and, an ion guide arranged so as to guide ions sourced from the ion source toward the ion filter device. The ion source and the ion filter device are arranged relative to one another so that the profile of the apparatus is reduced so as to minimize the effective footprint of the apparatus.

Abstract: The invention relates to a method for the in vitro detection and/or differentiation and/or progress observation of pathophysiological conditions with the aid of sample nucleic acids, including determination of gene activities by means of a plurality of polynucleotides, determination of gene activities of at least one internal reference gene, and formation of an index value from the single determined normalized gene activities of a multigene biomarker indicating the pathophysiological condition.

Abstract: The invention discloses a method for identifying a subset of polynucleotides from an initial set of polynucleotides corresponding to the human genome for the in vitro determination of severity of the host response of a patient having a severe infectious and/or inflammatory condition, in a sample, a measuring device comprising a plurality of different gene probes which represent the entire human genome, the test persons, depending on their infectious and/or inflammatory status, are divided into at least two clinically determined phenotype groups, changes of the gene expression signals between the phenotype groups are compared statistically, and gene probes are selected based on the gene expression signals which have significantly changed statistically between at least two phenotype groups.

Abstract: The present invention relates to a method for separating, determining or accumulating different DNA species that are present simultaneously in a sample, on the basis of unmethylated CpG-dinucleotides occurring with different frequency, within each DNA species present, wherein an unmethylated CpG motifs binding protein is immobilized on a base material and the DNA bound to the immobilized protein is eluted using an elution agent gradient, wherein specific concentration regions of the elution agent used correlate with specific CpG-dinucleotide frequencies in the DNA species present, so that during elution different fractions of DNA species are obtained that have different frequencies of CpG-dinucleotides.