Abstract: Described herein are compositions and methods for the delivery of microbial therapeutics useful for the treatment of disorders related to intestinal dysbiosis.

Abstract: In one embodiment, a ladar system includes a laser transmitter with at least one semiconductor laser having a pulsed laser light output. A laser drive circuit is connected to said at least one semiconductor laser and adapted to electrically drive said at least one semiconductor laser in a predetermined sequence. A laser beam steering mechanism is adapted to scan the pulsed laser light output sequentially through the field of view. A two-dimensional array of light sensitive detectors receive reflected light and an integrated circuit calculates a direct time of flight distance measurement.

Abstract: A system and method for capturing and sharing console gaming data is described. Embodiments capture gameplay data directly at the gaming console, without the need for external hardware. This allows users to easily capture rich console gaming experiences and share them across a variety of outlets. In one embodiment, the methods described herein can be implemented with a patch or driver on the operating system of the user device, rendering it unnecessary to heavily modify the source code of the game.

Abstract: A protective barrier affixable to a curved substrate comprises a stack of two or more lenses, each of the two or more lenses including a polyethylene terephthalate (PET) film, a hard coat on a first side of the PET film, and an adhesive layer on a second side of the PET film opposite the first side. The stack of two or more lenses may have a modulation transfer function that exhibits a contrast value greater than 75% for a spatial resolution of one line-pair per 0.0003 radians at 65 degrees angle of incidence. Heat and pressure may be applied to conform the stack of two or more lenses to the shape of the curved substrate.

Abstract: A method of dosing multiple drugs for an individual patient, by collecting data from the individual patient including drugs to be taken by the patient and genetic testing information, analyzing the individual patient data in view of dosing criteria established based on outside patient data, and determining doses of multiple drugs for each drug taken by the individual patient. A logic engine for dosing multiple drugs, including an algorithm stored on non-transitory computer readable media for collecting outside data to establish criteria for dosing multiple drugs to an individual patient and storing the outside data and individual patient data in a database, analyzing the individual patient data in view of criteria established from the outside data, and determining a dose for each drug to be taken.

Abstract: Disclosed are various examples identifying time-sensitive tasks being performed by a user of a client device that may be affected by a network connectivity issue associated with the client device and alerting the user interacting with the client device of the identified time-sensitive tasks. Network connectivity data associated one or more client devices can be used to identify patterns and context in network connectivity loss based at least in part on location, time, date, etc. Additionally, user context data associated with a user can be analyzed to predict whether the user will experience any connectivity issues and identify any tasks or action items being performed by the user interacting with the client device that may be considered time-sensitive. A user can be notified of a potential connectivity issue that may affect the ability for the user to complete a time-sensitive task.

Abstract: An electronic smoking article includes a reservoir including a liquid aerosol formulation, a heater operable to at least partially volatilize the liquid aerosol formulation and form an aerosol and a spiral path insert including a channel having a spiral configuration along an outer periphery of the spiral path insert. A coating can be applied to the outer periphery of the spiral path insert.

Abstract: A system for utilizing human machine interfaces to engage at least one passenger when a driver of a vehicle is distracted includes a system controller in communication with a plurality of passenger human machine interfaces and adapted to modify a display screen of a front seat passenger HMI, and an occupant monitoring system adapted to monitor the driver of the vehicle and the at least one passenger within the vehicle, the system controller adapted to determine, with a distracted driver algorithm within the system controller and data from the occupant monitoring system that the driver of the vehicle is distracted, and, when the driver of the vehicle is distracted, to actuate the plurality of passenger HMIs to engage the at least one passenger and encourage the at least one passenger to engage with the driver of the vehicle.

Abstract: A surface cleaning head may include a fluid distributor configured to distribute a cleaning fluid, an agitator configured to absorb at least a portion of the distributed cleaning fluid and to agitate debris on the surface to be cleaned, a fluid stripper configured to remove, from the agitator, at least a portion of the distributed cleaning fluid absorbed by the agitator, a debris container, and a removable cover. The debris container may include a solid debris chamber and a fluid debris chamber. The removable cover may include a fluid catch plate configured to transfer at least a portion of the cleaning fluid removed from the agitator by the fluid stripper to the fluid debris chamber, the fluid catch plate being configured to selectively transition between an in-use position and a cleaning position when the removable cover is removed from the surface cleaning head.

Abstract: An inorganic substrate with an improved via shape and methods for facilitating formation of such improved via shape are disclosed. A double-sided opening process may be applied to an inorganic substrate to form openings at the ends of a damage track previously formed in the inorganic substrate. One side of the inorganic substrate may then be sealed, such as by being temporarily bonded to a carrier or blocking substrate, so that a single-sided opening process may be applied to the other unsealed or unblocked surface of the inorganic substrate. The single-sided opening process may enlarge at least one of the openings formed by the double-sided opening process and may enlarge a channel between the openings to form a via having an advantageous shape.

Abstract: The present invention provides methods for treating cancer in a subject with a trisubstituted benzotriazole derivative with the formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2 and R3 are as defined herein.

Abstract: Provided are methods for post drop-off passenger assistance, which can include obtaining location data indicative of an environment where an autonomous vehicle is operating, determining a completion parameter indicative of a completion of a ride of the autonomous vehicle, determining, an assistance parameter indicative of an assistance of the autonomous vehicle to a passenger of the autonomous vehicle to be provided after the completion of the ride, and controlling an operation of the autonomous vehicle for assisting the passenger. Some methods described also include obtaining sensor data and controlling operation of the autonomous vehicle based on the sensor data. Systems and computer program products are also provided.

Abstract: A microelectromechanical systems (MEMS) device comprises a MEMS die that comprises first and second diaphragms, a first plurality of electrodes each disposed on the first diaphragm, and a second plurality of electrodes each disposed on the second diaphragm. A fixed dielectric element is disposed between the first and second diaphragms and includes a plurality of apertures. The MEMS die further comprises a third plurality of electrodes, wherein each of the third plurality comprises a first conductive layer disposed on the first diaphragm proximate to at least one of the first plurality and a second conductive layer disposed on the second diaphragm proximate to at least one of the second plurality, and a conductive pin that extends through an aperture of the plurality of apertures and electrically connects the first conductive layer to the second conductive layer.

Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, Cy, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: This document describes techniques and apparatuses that enable determining expected hash-values in functions with control flow. A computing device receives a function comprising function instructions within at least three basic blocks connected via multiple execution paths. Hash-input instructions are inserted within a plurality of the basic blocks that indirectly force hash values at the respective insertion points. Hash values at ends of the plurality of the basic blocks are set to a canonical value and an expected hash-value and hash input-values are calculated using a hash function. By using the canonical value and the hash input-values, the expected hash-value is the same regardless of which execution path is executed.

Abstract: While a vehicle is off, an automatic trigger strategy activates a heating device that melts snow and ice off exterior vehicle sensors as it is needed. The automatic trigger strategy determines when to turn on the heating device while the vehicle is in a limited power state by using data pulled from memory or data obtained from a current data check. Collected, analyzed, and stored during key-off, data pulled from memory allows the invention to accurately choose the correct time to start the heating device without consuming additional power. If current data checks are required because data saved at key-off is not enough information to execute a decision, the invention may determine the least power consuming data checks. A power manager extends a threshold that is dependent on the energy reserve. Once the energy reserve is below the threshold, the power manager inactivates the heating device and voids manual commands.

Abstract: Provided herein are systems and methods for identifying personal identifiers in content. An entity engine may receive content to identify candidate personal identifiers. The entity engine may determine that a text string in the content matches to a data format specified in entity definitions corresponding to types of personal identifiers and a rule for finding a geographic or linguistic term in the content correlated to the specific type of personal identifier. Each entity definition may specify a data format for finding a specific type of personal identifier in content. The data format corresponds to a type of personal identifier. The entity engine may identify, according to a rule of the first entity definition, a geographic or linguistic term in the content correlated to the type of personal identifier. The entity engine may classify the text string as the type of personal identifier, for preventing data breach or exfiltration.