Abstract: The present invention provides a model or tool for predicting the editing efficiency of sgRNA in a CRISPR/Cas gene editing system, in particular a CRISPR/dCas epigenetic editing system, a training and prediction method thereof, and a related computer system, computer storage medium, and application. In particular, one or more sgRNA and target gene related epigenetic features are added to an input of the model.

Abstract: According to an aspect of the present invention, there is provided a terminal station device in a passive optical communication network in which the terminal station device and a subscriber line termination device are connected to each other, the terminal station device including: a distance measurement unit that measures a distance between the terminal station device and the subscriber line termination device; a signal intensity measurement unit that measures an intensity of a signal received from the subscriber line termination device; and an estimation unit that estimates an occurrence of a sign of a failure in the subscriber line termination device based on a measurement result of the distance by the distance measurement unit and a measurement result of the intensity of the signal by the signal intensity measurement unit.

Abstract: The switch device comprises a lower electrode, an upper electrode, and a switch material layer disposed between the lower electrode and the upper electrode. When the switch device is in an on state, the switch material layer is in a liquid state and has a bandgap of 0; when the switch device is in an off state, the switch material layer is in a crystalline state, and a Schottky barrier is formed between the switch material layer and the upper electrode, as well as between the switch material layer and the lower electrode. The switch device employs the crystalline-liquid-crystalline phase change mechanism of the switch material, and can drive memory units, such as phase change memory units, resistive memory units, ferroelectric memory units, magnetic memory units, and the like, thereby enabling high-density three-dimensional information storage.

Abstract: A convertible furniture apparatus includes a frame; a convertible assembly connected to the frame via at least a pair of pivot points each connected to respective side panels of the frame, the convertible assembly configured to transition between a first position and a second position by pivoting about the pivot points; and a binding assembly configured to selectively cinch the convertible assembly to the frame, when the convertible assembly is in the first position or the second position.

Abstract: The following processing is performed in the learning phase. The base station device transmits a control signal toward the relay device. The relay device dynamically selects a phase weight that determines the beam direction of the reflected wave according to the set value. A channel state of the CH2 is estimated from a low-frequency CH2 reference signal that has arrived at the base station device from the terminal device. The communication quality of the CH1 is measured from the high-frequency CH1 reference signal that has arrived at the base station device from the terminal device. A learning model is generated by learning the set value, the channel state, and the communication quality. In the estimation phase, the latest channel state acquired by the CH2 is applied to the learning model, and an optimum set value predicted to maximize the communication quality under the latest state is estimated.

Abstract: An operation method of performing a neural network operation of fully homomorphic encrypted data is provided. The operation method includes: receiving data for performing the neural network operation and receiving a parameter for generating an approximation polynomial corresponding to the neural network operation; obtaining layer information corresponding to layers of a neural network model, the layer information based on the data; determining importances of the layers, respectively, wherein the determining of the importances is based on the parameter and the layer information; generating an approximation polynomial approximating the neural network operation for each of the layers, wherein the generating is based on the layer importance; and generating an operation result by performing the neural network operation based on the approximation polynomial, wherein the parameter includes a computation time condition that the neural network operation must satisfy.

Abstract: A fabricated rapid construction platform for a bridge, wherein the construction platform comprises a fixing frame, an upper-layer tubular pile position control structure (6), a lower-layer tubular pile position control structure (7), and a console; the fixing frame comprises a bottom rail platform (1), supporting posts (3), a top operation platform (2), and several supporting legs (4); the upper-layer tubular pile position control structure (6) and the lower-layer tubular pile position control structure (7) are provided between the bottom rail platform (1) and the top operation platform (2); the upper-layer tubular pile position control structure (6) comprises two sub-structures arranged symmetrically about the central axis of a second through hole, and each sub-structure comprises a braking device (61), a vertical control arm (63), and a horizontal control arm (62).

Abstract: Disclosed herein are a data race detection method and apparatus. The data race detection method includes recording information about an instruction executed by a thread in a destination register in a Central Processing Unit (CPU) corresponding to the thread, setting information of an access log field corresponding to the instruction for a cache line of a cache memory, and detecting a data race using the information of the access log field and information of the destination register.

Abstract: A generation device (10) includes: a 3D reconstruction unit (12) that reconstructs an original three-dimensional image based on a plurality of images and a plurality of depth images, and acquires information indicating a position, a posture, a shape, and an appearance of a mapping target object that is a target of mapping to a digital space, and position information and posture information of an imaging device that has captured the image and the depth image; a labeling unit (13) that acquires a plurality of two-dimensional images in which labels or categories are associated with all pixels in an image based on the plurality of images; an estimation unit (14) that estimates a material and mass of the mapping target object based on the plurality of two-dimensional images and the position information and the posture information of the imaging device; and a generation unit (16) that integrates the information indicating a position, a posture, a shape, and an appearance of the mapping target object, and the inform

Abstract: The crosslinked peptidomimetic macrocycles disclosed herein comprise an alkene or alkyne staple and a poly-amino acid C-terminal tail. These crosslinked peptidomimetic macrocycles have improved binding to MDM2 and MDMX (aka MDM4), are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

Abstract: Carbon nanofiber doped alumina (Al-CNF) supported MoCo catalysts in hydrodesulfurization (HDS), and/or boron doping, e.g., up to 5 wt % of total catalyst weight, can improve catalytic efficiency. Al-CNF-supported MoCo catalysts, (Al-CNF-MoCo), can reduce the sulfur concentration in fuel, esp. liquid fuel, to below the required limit in a 6 h reaction time. Thus, Al-CNF-MoCo has a higher catalytic activity than Al—MoCo, which may be explained by higher mesoporous surface area and better dispersion of MoCo metals on the AlCNF support relative to alumina support. The BET surface area of Al—MoCo may be 75% less than Al-CNF-MoCo, e.g., 166 vs. 200 m2/g. SEM images indicate that the catalyst nanoparticles can be evenly distributed on the surface of the CNF. The surface area of the AlMoCoB 5% may be 206 m2/g, which is higher than AlMoCoB 0% and AlMoCoB 2%, and AlMoCoB 5% has the highest HDS activity, removing more than 98% sulfur and below allowed levels.

Abstract: A processor-implemented method includes receiving data for performing a neural network operation of homomorphic encrypted data and a parameter for generating an approximate polynomial corresponding to the neural network operation, obtaining layer information corresponding to each of a plurality of layers configuring a neural network based on the data, determining layer importance corresponding to each of the plurality of layers, based on the parameter and the layer information, generating an approximate polynomial approximating the neural network operation for each of the plurality of layers, based on the layer importance, and generating an operation result by performing the neural network operation based on the approximate polynomial.

Abstract: An embodiment of the invention provides chimeric antigen receptor (CAR) amino acid constructs. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CAR constructs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. Methods of making the CAR constructs are disclosed.

Abstract: A method of detecting Hg2+ ions in an aqueous solution is described. The method includes contacting the aqueous solution with a metal-organic framework (MOF) chemosensor composite to form a mixture and monitoring a change in an absorption and/or a fluorescence profile of the MOF chemosensor composite in the mixture to determine a presence or absence of Hg2+ ions in the aqueous solution. The MOF chemosensor composite includes fluorescein hydrazide (FH); and a MOF, including nickel as a metal ion and at least one trimesic acid (BTC) ligand. A hydrazide group on the fluorescein hydrazide coordinates to the metal ion of the MOF.

Abstract: An encoding circuit including: a serial-parallel circuit that performs serial-parallel conversion on input data of a uniform sequence to divide the data into a plurality of pieces of divided data; a sequence conversion unit that encodes the divided data and converts the encoded divided data into divided data of a non-uniform sequence; a parallel-serial circuit that converts the divided data and the divided data of the non-uniform sequence converted by the sequence conversion unit into serial data by performing parallel-serial conversion; an external encoding unit that adds an error correction code to the serial data and encodes the serial data; a division unit that divides the serial data to which the error correction code is added into a plurality of pieces of divided data; a bit conversion circuit that regards the plurality of pieces of divided data divided as data to be transmitted in different subchannels and converts a bit sequence to make a communication channel capacity of each subchannel non-uniform;

Abstract: There is provided a data processing device 10 that performs a convolution operation of two pieces of input data of 2M×N bits (N is a positive integer and M is a natural number) width with a minimum accuracy of the convolution operation being N bits, and performs processing corresponding to a plurality of the consecutive M, the data processing device 10 including: a product-sum operation unit 101 that performs a product-sum operation according to the value of M; a shifter 102 that performs shift processing on a result of a product-sum operation of the product-sum operation unit 101 in a case where the value of M is not 0; an addition unit 103 that performs addition processing on each output of the shifter 102 or the product-sum operation unit 101 according to the value of M; a selector 105 that selects an output from the addition unit 103 according to the value of M; a cumulative addition unit 106 that cumulatively adds the outputs from the selector 105; and a cumulative addition memory 107 that stores outputs

Abstract: An estimation method in an optical transmission system that performs communication by a digital coherent system including an optical transmission device and an optical reception device, the estimation method including calculating a ratio of a linearly transformed amount after converting a tap coefficient of a digital filter included in the optical reception device into a frequency domain signal by digital Fourier transform, and estimating a physical quantity related to at least a response between the optical transmission device and the optical reception device based on amplitude and phase information of the ratio of the calculated linearly transformed amount.

Abstract: A method of enhancing oil recovery from a carbonate reservoir containing a hydrocarbon mixture includes injecting the carbonate reservoir with a sea-water solution comprising a citric acid-based additive to displace the hydrocarbon mixture from the carbonate reservoir thereby forming a hydrocarbon mixture containing sea-water mixture; and separating the hydrocarbon mixture from the hydrocarbon mixture containing sea-water mixture to recover the hydrocarbon mixture. The citric acid-based additive is present in the sea-water solution at a concentration of 1 to 1000 parts per million based on a total number of parts by weight of the sea-water solution. Particles of the citric acid-based additive are adsorbed on surfaces of the carbonate rocks in the carbonate reservoir.

Abstract: Provided is an acoustic signal output device including a housing that emits an acoustic signal, and a wearable portion that holds the housing and is formed to be worn on an auricle. Provided that the wearable portion includes a fixing portion including a concave inner wall surface formed to be fitted into an upper portion of the auricle, and a shielding wall formed to cover only a part of the auricle when a side of the inner wall surface of the fixing portion is fitted into an upper portion of the auricle.

Abstract: Carbon nanofiber doped alumina (Al-CNF) supported MoCo catalysts in hydrodesulfurization (HDS), and/or boron doping, e.g., up to 5 wt % of total catalyst weight, can improve catalytic efficiency. Al-CNF-supported MoCo catalysts, (Al-CNF-MoCo), can reduce the sulfur concentration in fuel, esp. liquid fuel, to below the required limit in a 6 h reaction time. Thus, Al-CNF-MoCo has a higher catalytic activity than Al—MoCo, which may be explained by higher mesoporous surface area and better dispersion of MoCo metals on the AlCNF support relative to alumina support. The BET surface area of Al—MoCo may be 75% less than Al-CNF-MoCo, e.g., 166 vs. 200 m2/g. SEM images indicate that the catalyst nanoparticles can be evenly distributed on the surface of the CNF. The surface area of the AlMoCoB5% may be 206 m2/g, which is higher than AlMoCoB0% and AlMoCoB2%, and AlMoCoB5% has the highest HDS activity, removing more than 98% sulfur and below allowed levels.