Abstract: Methods for improving the functionality and/or fertility of sperm, for example, by enhancing motility and extending the lifespan of sperm in the FRT, by adding functional molecules of interest attached to a membrane anchoring agent-PEG conjugate to the surface of the sperm are provided. Such methods may be used in AI to reduce the number of sperm needed for insemination and to improve conception rates.
Type:
Application
Filed:
August 8, 2012
Publication date:
October 23, 2014
Applicant:
ANDROGENIX LTD.
Inventors:
Bridget Lee Dicker, Jiwon Hong, Keith Hudson, Shakeela Nathalia Jayasinghe
Abstract: Methods for improving the functionality and/or fertility of sperm, for example, by enhancing motility and extending the lifespan of sperm in the female reproductive tract, by adding PEG to the surface of the sperm are provided. Such methods may be used in artificial insemination to reduce the number of sperm needed for insemination and to improve conception rates.
Type:
Grant
Filed:
February 9, 2011
Date of Patent:
November 26, 2013
Assignee:
Androgenix Ltd.
Inventors:
Keith Hudson, Bridget Lee Dicker, Jiwon Hong, Shakeela Nathalia Jayasinghe
Abstract: Methods for improving the functionality and/or fertility of sperm, for example, by enhancing motility and extending the lifespan of sperm in the female reproductive tract, by adding PEG to the surface of the sperm are provided. Such methods may be used in artificial insemination to reduce the number of sperm needed for insemination and to improve conception rates.
Type:
Application
Filed:
February 9, 2011
Publication date:
December 27, 2012
Applicant:
ANDROGENIX LTD.
Inventors:
Keith Hudson, Bridget Lee Dicker, Jiwon Hong, Shakeela Nathalia Jayasinghe
Abstract: Materials and Methods for the separation of X- and Y-chromosome bearing sperm, for example in a semen sample, are provided. The methods involve contacting the semen sample with a binding agent, such as an antibody, that specifically binds to an antigen that is specific for an X- or Y-chromosome. Kits for use in the methods are also provided.