Abstract: The present invention is directed toward formulation and method for oral transmucosal delivery of a pharmaceutical. The invention provides a drug formulation comprising a solid pharmaceutical agent in solid solution with a dissolution agent. The formulation is administered into a patient's oral cavity, delivering the pharmaceutical agent by absorption through a patient's oral mucosal tissue. The formulation and method provide for improved oral mucosal delivery of the pharmaceutical agent.

Abstract: An apparatus for the reusable interim storage of partially consumed medicated oral dosage forms and methods for employing such an apparatus in order to use medicated oral dosage forms in the safest possible manner. The apparatus of the present invention in its broadest terms comprises (1) a container sized to hold a medicated oral dosage form, (2) means for allowing a medicated oral dosage form easy access into the container but substantially preventing the medicated oral dosage form from passing out of the container, and (3) a child resistant means for allowing an adult to remove a medicated oral dosage form from within the container despite the one-way access means. The preferred embodiment comprises an opaque container having one opening, a child resistant closure with an aperture there through that extends over said opening, and a plastic slitted membrane covering said aperture.

Abstract: The present invention is directed to novel methods and apparatus for noninvasively collecting substances through mucosal tissues. The concentration of a substance in blood is monitored noninvasively by correlation with the amount of the substance which permeates a mucosal membrane into a substance receiving medium over a specified time period. The substance receiving medium may include an substance permeation enhancer capable of increasing the substance permeability across the mucosal membrane. The substance receiving medium is positioned against the mucosal membrane. After sufficient time delay, the substance receiving medium is removed and analyzed for the concentration of a substance to be measured using known analytical techniques.The apparatus within the scope of the present invention includes means for supporting the substance receiving medium. The means for supporting the receiving medium provides an added benefit of isolating the substance receiving medium from contamination sources.