Abstract: Conjugates are provided, comprising a targeting protein, e.g., an anti-TM4SFI antibody or antigen or binding fragments thereof. Methods of manufacture and use of said conjugates are also described.
Type:
Grant
Filed:
June 12, 2019
Date of Patent:
November 4, 2025
Assignee:
ANGIEX, INC.
Inventors:
Paul A. Jaminet, Shou-Ching S. Jaminet, Edward Ha
Abstract: Antibody-drug conjugates (ADCs) are described, comprising anti-TM4SF1 antibodies, and antigen-binding fragments thereof. Methods of use of said ADCs are also described.
Type:
Grant
Filed:
February 27, 2020
Date of Patent:
September 30, 2025
Assignee:
ANGIEX, INC.
Inventors:
Paul A. Jaminet, Shou-Ching S. Jaminet, Edward H. Ha, Leonard G. Presta, Manish S. Hudlikar
Abstract: Anti-TM4SF1 antibodies, and antigen-binding fragments thereof, are described that bind to an epitope on the ECL2 loop of human TM4SF1. Methods of use of said antibodies and fragments are also described, including for the inhibition of metastasis.
Type:
Grant
Filed:
August 28, 2018
Date of Patent:
December 28, 2021
Assignee:
ANGIEX, INC.
Inventors:
Paul A. Jaminet, Shou-Ching S. Jaminet, Harold F. Dvorak, Leonard G. Presta