Abstract: Anti-TM4SF1 antibodies, and antigen-binding fragments thereof, are described that bind to an epitope on the ECL2 loop of human TM4SF1. Methods of use of said antibodies and fragments are also described, including for the inhibition of metastasis.
Type:
Grant
Filed:
August 28, 2018
Date of Patent:
December 28, 2021
Assignee:
ANGIEX, INC.
Inventors:
Paul A. Jaminet, Shou-Ching S. Jaminet, Harold F. Dvorak, Leonard G. Presta