Abstract: The present application provides anti-Sclerostin constructs that bind to Sclerostin (e.g., anti-Sclerostin antibodies, e.g., bispecific anti-Sclerostin antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-Sclerostin, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-Sclerostin construct, pharmaceutical compositions containing the anti-Sclerostin construct, and methods of using the anti-Sclerostin construct or compositions.