Patents Assigned to Anima Biotech Inc.
  • C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20250109128
    Abstract: The present invention relates to novel c-Myc mRNA translation modulators, composition and methods of preparation CA thereof, and uses thereof in the treatment of cancer.
    Type: Application
    Filed: March 15, 2023
    Publication date: April 3, 2025
    Applicant: Anima Biotech Inc.
    Inventors: David William SHEPPARD, Jason Paul TIERNEY, Aviad MANDABI, Iris ALROY, Rina WASSERMANN, Yoni SHEINBERGER
  • COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230212131
    Abstract: The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and alcoholic and non-alcoholic steatohepatitis (NASH).
    Type: Application
    Filed: June 9, 2021
    Publication date: July 6, 2023
    Applicant: Anima Biotech Inc.
    Inventors: David William SHEPPARD, Jason Paul TIERNEY, Aviad MANDABI, Wolfgang SCHMIDT, Stefano LEVANTO, Julie Nicole HAMBLIN, Richard James BULL, Iris ALROY, Wissam MANSOUR, Moty KLEPFISH, Yaode WANG, Haitang LI
  • COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230150980
    Abstract: The present invention relates to novel Collagen I translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and alcoholic and non-alcoholic steatohepatitis (NASH).
    Type: Application
    Filed: April 21, 2021
    Publication date: May 18, 2023
    Applicant: Anima Biotech Inc.
    Inventors: David William SHEPPARD, Jason Paul TIERNEY, Aviad MANDABI, Wolfgang SCHMIDT, Stefano LEVANTO, Julie Nicole HAMBLIN, Richard James BULL, Iris ALROY, Wissam MANSOUR, Moty KLEPFISH, Yaode WANG, Haitang Ll, Stephen David PENROSE
  • COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230116201
    Abstract: The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and alcoholic and non-alcoholic steatohepatitis (NASH).
    Type: Application
    Filed: January 28, 2021
    Publication date: April 13, 2023
    Applicant: Anima Biotech Inc.
    Inventors: David William SHEPPARD, Jason Paul TIERNEY, Wolfgang SCHMIDT, William Rameshchandra ESMIEU, Julie Nicole HAMBLIN, Richard James BULL, Iris ALROY, Wissam MANSOUR, Moty KLEPFISH, Aviad MANDABI
  • C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20220370431
    Abstract: The present invention relates to novel c-MYC mRNA translation modulators, composition and methods of preparation thereof, and uses thereof in the treatment of cancer.
    Type: Application
    Filed: July 3, 2022
    Publication date: November 24, 2022
    Applicant: Anima Biotech Inc.
    Inventors: David William SHEPPARD, Jason Paul TIERNEY, Aviad MANDABI, Iris ALROY, Rina WASSERMANN, Yaode WANG, Haitang LI, Yoni SHEINBERGER
  • Functional tRNA-aptamer molecules
    Patent number: 11085045
    Abstract: The present invention provides functional aptamer-comprising tRNA molecules, useful in the study of tRNA and ribosomal activity.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: August 10, 2021
    Assignees: Anima Biotech Inc., Thomas Jefferson University
    Inventors: Iris Alroy, Ya-Ming Hou, Howard Gamper
  • Fluorescent labeling of transfer RNA and study of protein synthesis
    Patent number: 10921326
    Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: February 16, 2021
    Assignees: The Trustees of the University of Pennsylvania, Anima Biotech Inc.
    Inventors: Barry S. Cooperman, Zeev Smilansky, Yale E. Goldman, Dongli Pan