Abstract: A disease management system, methods, and devices are shown and described. In one embodiment, the system includes an infusion pump and a remote controller with the ability to be paired to each other. A method to verify a wireless connection between an infusion pump and a remote controller is shown and described herein. In a further embodiment, a method to verify a wireless connection between an infusion pump and a remote controller is provided. In addition, a method of operating a diabetes management system is provided in which the system includes an infusion pump and at least a remote controller.

Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.

Abstract: Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

Abstract: Described is a cartridge cap with a feature that aides in the removal of a battery cap from a drug infusion pump. The proximal end of the cartridge cap includes a recess on an inner surface that receives a tab on a distal end of the battery cap. To remove the battery cap from the drug infusion pump, the proximal end of the cartridge cap is placed over the distal end of the battery cap such that the recess in the cartridge cap receives the tab on the battery cap. The cartridge cap is then rotated counterclockwise until the battery cap is removed from the drug infusion pump.

Abstract: The invention relates to a mechanical drive system for a medical infusion device. The disclosed drive system employs a flexible tape with recesses or holes that are configured to mate with tabs or protrusions on a gear to advance the rotation of the gear at a rate determined by the pattern of recesses or holes on the flexible tape.

Abstract: A syringe assembly for use with an infusion pump having a drive piston. The syringe assembly comprises a substantially hollow syringe housing and a plunger axially movable within the syringe housing to dispense a fluid therefrom. The plunger has a body with a portion thereof configured to engage a radially elastic member associated with the drive piston such that the plunger is releasably axially secured relative to the drive piston.

Abstract: The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors.

Abstract: The invention relates to a novel display system for a drug delivery device that reduces power consumption and permits the user of the device to see messages when the device is not in a powered state or when the device has encountered an error condition. By using a bistable display, the medical device is able to maintain messages that can been seen by the user even when the device's power supply is exhausted or when the device has encountered an error that interrupts its normal operation. The use of such a display also improves the battery life by eliminating the need to provide power to the display screen when it is not being updated.

Abstract: Described is a spring-loaded cartridge cap for use in a drug infusion pump. The cap is ejected if it is not properly inserted into the pump. In one embodiment, the cap includes three detent pins that mate with detents in a cartridge chamber within the drug infusion pump. As the cap is inserted into the cartridge chamber of the drug infusion pump, the distal end of the cartridge compresses a coil spring within the cap. To secure the cap within the cartridge chamber, the cap is rotated such that each detent pin moves within a slot until a locking detent is engaged.

Abstract: A medical device pump with a housing with a compartment for removably receiving a cartridge containing a therapeutic agent, a conduit configured to operatively provide a fluid flow path for therapeutic agent to exit from the cartridge, a user activated delivery button, a trigger mechanism, and a mechanical pump mechanism. The trigger mechanism, user activated delivery button and mechanical pump mechanism of the medical device pump are configured such that the trigger mechanism is activated by a user fully activating the user activated delivery button. Moreover, such full activation generates mechanical power employed by, and sufficient for, the mechanical pump mechanism to pump a predetermined volume of therapeutic agent from the cartridge and through the fluid flow path.

Abstract: The invention, in general, relates to communications systems for medical devices. In particular, the present invention is directed toward a communications routine for a medical infusion devices and a remote control unit that includes data elements within the transmissions that indicate the operating status of the infusion device.

Abstract: The invention relates to a drug infusion device which may include a remote control unit and/or remote control unit capable of sampling and analyzing blood and interstitial bodily fluids. More particularly, the invention also describes a mechanism for delivering a fluid medication from a reservoir to a patient using a flexible reservoir and a stepped piston pump.

Abstract: Described is a drive mechanism for a drug infusion pump. In one embodiment, an in-line drive mechanism is provided that includes a motor operatively coupled to a lead screw, which is configured to engage a piston. The piston includes a cavity to receive the motor and the lead screw such that the lead screw and at least a portion of the motor are substantially contained within the piston cavity when the piston is in a retracted position. In one embodiment, at least a portion of the motor is also substantially contained within a cavity of the lead screw regardless of whether the piston is in the retracted or extended position. The configuration of the piston, the lead screw and the motor results in a more compact drug delivery device.

Abstract: The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.

Abstract: Described is a seal used in a drug delivery device. In one embodiment, a seal is provided that includes a tongue, a groove and a coating formed on at least one surface of the tongue, the groove or both the tongue and the groove. In another embodiment, a drug delivery device is provided that includes a housing having a top portion and a bottom portion, a tongue formed on the periphery of one of the top portion or bottom portion and a groove formed on the periphery of one of the top portion or bottom portion and configured to receive the tongue, and a coating on the surface of at least one of the groove and the tongue that creates a hermetic seal between the top portion and the bottom portion when the tongue and the groove are in contact.

Abstract: The invention relates to a device and method for treating diabetic patients on insulin therapy. More specifically, the invention includes apparatus for infusing insulin into a patient in an amount determined by the patient's carbohydrate intake, blood glucose level, and the amount of insulin calculated to be present in the patient at the time the therapy is to be administered. In one embodiment, an insulin infusion device having an on-board processor obtains a patient's blood glucose value from a remote sensor and receives input from a user indicating their recent meal intake. The device may include an on-board food database for determining the carbohydrate content of the patient's recent meals and compare that with recent insulin deliveries into the patient to determine the insulin present in the patient prior to determining an appropriate insulin dosage.

Abstract: A medical device flexible conduit includes an elongated Nitinol strip with a distal end, a proximal end, a longitudinal axis running from the distal end to the proximal end, a sharp head extending from the distal end, and a channel etched therein. Moreover, the channel is dispositioned along the longitudinal axis. The medical device flexible conduit also includes a flexible tube at least partially jacketing the elongated Nitinol strip between the distal end and the proximal end with the channel and the flexible tube defining a conduit. A method for manufacturing a medical device flexible conduit includes etching a channel into an elongated Nitinol strip and forming a sharp head on a distal end of the elongated Nitinol strip. The method also includes subsequently jacketing the flat elongated Nitinol strip with a flexible tube such that the flexible tube and channel define a conduit.

Abstract: Described is a drug delivery system and method for priming such drug delivery system so that unwanted delivery of a drug is prevented. In one embodiment, a drug delivery system is provided that includes a drug infusion pump and a cartridge configured for insertion into the drug infusion pump. The cartridge includes a hollow barrel for receiving and storing a drug and a plunger having a first end and a second end. The first end of the plunger is slidably insertable and movable within the barrel. The second end of the plunger is slidably insertable and movable with a chamber of the drug infusion pump. The second end of the plunger also includes an interlock that is passively engaged by a piston within the drug infusion pump during priming to prevent unwanted delivery of the drug.