Abstract: Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
Type:
Grant
Filed:
February 11, 2019
Date of Patent:
May 7, 2024
Assignee:
Anji Pharmaceuticals Inc.
Inventors:
Alain D. Baron, Mark S. Fineman, Nigel R. A. Beeley
Abstract: The present disclosure provides methods related to treating or preventing gastrointestinal dysfunction in a subject in need thereof, which include the use of a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor. The disclosure also provides pharmaceutical compositions comprising a DGAT1 inhibitor, or pharmaceutically acceptable salts or esters thereof, useful for the treatments described herein.
Type:
Grant
Filed:
December 30, 2021
Date of Patent:
November 21, 2023
Assignee:
Anji Pharmaceuticals Inc.
Inventors:
Brian K. Hubbard, Michael H. Serrano-Wu
Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
Type:
Grant
Filed:
July 14, 2021
Date of Patent:
September 19, 2023
Assignee:
Anji Pharmaceuticals Inc.
Inventors:
Alain D. Baron, Mark S. Fineman, Nigel R. A. Beeley
Abstract: The present disclosure provides methods related to inhibiting or treating pancreatitis in a subject in need thereof, which include the use of a proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor. The disclosed PCSK9 inhibitors and compositions including them can be used for treatment, inhibition, or prevention of pancreatitis in a subject. Treatment methods can include administering to the subject a therapeutically effective amount of a PCSK9 inhibitor.
Type:
Grant
Filed:
June 4, 2019
Date of Patent:
June 20, 2023
Assignee:
Anji Pharmaceuticals Inc.
Inventors:
Charles D. Meyers, Brian K. Hubbard, Michael H. Serrano-Wu
Abstract: The present disclosure provides methods related to treating or preventing gastrointestinal dysfunction in a subject in need thereof, which include the use of a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor. The disclosure also provides pharmaceutical compositions comprising a DGAT1 inhibitor, or pharmaceutically acceptable salts or esters thereof, useful for the treatments described herein.
Type:
Grant
Filed:
March 15, 2019
Date of Patent:
January 18, 2022
Assignee:
Anji Pharmaceuticals Inc.
Inventors:
Brian K. Hubbard, Michael H. Serrano-Wu