Abstract: Methods of using inhibitors of the CD2/LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage, e.g., photoaging, atopic dermatitis, cutaneous T cell lymphoma such as mycosis fungoides, allergic and irritant contact dermatitis, lichen planus, alopecia areata, pyoderma gangrenosum, vitiligo, ocular cicatricial pemphigoid, and urticaria.
Type:
Application
Filed:
February 13, 2004
Publication date:
July 15, 2004
Applicants:
Biogen, Inc., a Massachusetts Corporation, The Regents of the University of Michigan, Ann Arbor, Michigan Corporation