Patents Assigned to AnorMED, Inc.
  • Process for the synthesis of CXCR4 antagonist
    Patent number: 7332605
    Abstract: This invention relates to a process for synthesizing heterocyclic pharmaceutical compound which binds to the CXCR4 chemokine receptor.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: February 19, 2008
    Assignee: AnorMED, Inc.
    Inventors: Jason B. Crawford, Gang Chen, David Gauthier, Renato Skerlj, Ian R. Baird, Trevor R. Wilson
  • Chemokine receptor binding compounds
    Publication number: 20070066624
    Abstract: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
    Type: Application
    Filed: August 16, 2006
    Publication date: March 22, 2007
    Applicant: AnorMED, Inc.
    Inventors: Yuanxi Zhou, Elyse Bourque, Yongbao Zhu, Ernest McEachern, Curtis Harwig, Renato Skerlj, Gary Bridger, Tong-Shuang Li, Markus Metz
  • Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
    Publication number: 20070060757
    Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
    Type: Application
    Filed: November 14, 2006
    Publication date: March 15, 2007
    Applicant: AnorMED Inc.
    Inventors: Ernest McEachern, Gary Bridger, Krystyna Skupinska, Renato Skerlj, Wen Yang
  • Chemokine receptor binding heterocyclic compounds
    Patent number: 7183273
    Abstract: Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: February 27, 2007
    Assignee: AnorMED, Inc.
    Inventors: Gary J. Bridger, Renato Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols
  • Methods to treat conditions mediated by chemokine receptors
    Patent number: 7160872
    Abstract: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: January 9, 2007
    Assignee: AnorMED Inc.
    Inventors: Gary Bridger, Eva Maria Boehringer, Zhongren Wang, Dominique Schols, Renato Skerlj, David Bogucki
  • Chemokine receptor binding heterocyclic compounds
    Publication number: 20060264434
    Abstract: This invention relates to a novel class of heterocyclic compounds that bind chemokine receptors, inhibiting the binding of their natural ligands thereby. These compounds result in protective effects against infection by HIV through binding to chemokine receptors, including CXCR4 and CCR5, thus inhibiting the subsequent binding by these chemokines.
    Type: Application
    Filed: July 27, 2006
    Publication date: November 23, 2006
    Applicant: AnorMED Inc.
    Inventors: Gary Bridger, Renato Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor Wilson, Jason Crawford, Ernest McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols
  • Methods to mobilize progenitor/stem cells
    Publication number: 20060193826
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: November 8, 2005
    Publication date: August 31, 2006
    Applicant: AnorMED Inc.
    Inventors: Gary Bridger, Michael Abrams, Geoffrey Henson, Ronald MacFarland, Gary Calandra, Hal Broxmeyer, David Dale
  • Chemokine receptor binding heterocyclic compounds
    Patent number: 7091217
    Abstract: Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: August 15, 2006
    Assignee: AnorMED, Inc.
    Inventors: Gary Bridger, Renato Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis Smith, Maria Rosaria Di Fluri
  • Chemokine receptor binding heterocyclic compounds
    Patent number: 7022717
    Abstract: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: April 4, 2006
    Assignee: AnorMED, Inc.
    Inventors: Gary James Bridger, Eva Maria Boehringer, Zhongren Wang, Dominique Schols, Renato Tony Skerlj, David Earl Bogucki
  • Platinum complexes as antitumor agents
    Patent number: 6894049
    Abstract: The present invention relates to platinum antitumor drugs. In particular, it relates to platinum complexes having formula Ia or Ib or a pharmaceutically acceptable salt thereof wherein: each A is independently an anion; each B is independently halo, hydroxy, carboxylate, carbamate or a carbonate ester, Z is a substituted 5- or 6-membered, heterocyclic moiety wherein at least one substituent sterically hinders access of the Pt atom to a DNA strand of a tumor cell, and wherein Z is other than pyridine; and X is NH3 or mono- or dialkyl substituted NH3. which are active against cancer cells and have improved aqueous solubility and activity.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: May 17, 2005
    Assignee: AnorMED, Inc.
    Inventors: Ernest S. Y. Wong, Christen M. Giandomenico
  • Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
    Publication number: 20050080267
    Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
    Type: Application
    Filed: October 6, 2004
    Publication date: April 14, 2005
    Applicant: AnorMED, Inc.
    Inventors: Ernest McEachern, Gary Bridger, Krystyna Skupinska, Renato Skerlj
  • Chemokine receptor binding heterocyclic compounds
    Patent number: 6864265
    Abstract: Compounds that bind to chemokine receptors such as CXCR4 and CCR5 demonstrate protective effects against infection of cells by human immunodeficiency virus are disclosed. These compounds contain a tertiary amine[[s]] linked to a core nitrogen via an aromatic or heteroaromatic moiety.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: March 8, 2005
    Assignee: AnorMED, Inc.
    Inventors: Gary Bridger, Renato Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason Crawford, Ernest J. Mceachern, Bern Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis, Rosaria Maria Di Fluri
  • Chemokine receptor binding heterocyclic compounds
    Patent number: 6835731
    Abstract: Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: December 28, 2004
    Assignee: AnorMED, Inc.
    Inventors: Gary Bridger, Renato Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis, Rosaria Maria Di Fluri
  • Chemokine receptor binding heterocyclic compounds
    Patent number: 6750348
    Abstract: This invention relates to a novel class of heterocyclic compounds that bind chemokine receptors, inhibiting the binding of their natural ligands thereby. These compounds result in protective effects against infection by HIV through binding to chemokine receptors, including CXCR4 and CCR5, thus inhibiting the subsequent binding by these chemokines.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: June 15, 2004
    Assignee: AnorMED, Inc.
    Inventors: Gary Bridger, Renato Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols
  • Chemokine receptor binding heterocyclic compounds
    Patent number: 6734191
    Abstract: Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: May 11, 2004
    Assignee: AnorMED, Inc.
    Inventors: Gary Bridger, Renato Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason Crawford, Ernest J. McEachern, Bern Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis, Rosaria Maria Di Fluri
  • Antiviral compounds
    Patent number: 6506770
    Abstract: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: January 14, 2003
    Assignee: AnorMED, Inc.
    Inventors: Gary James Bridger, Eva Maria Boehringer, Zhongren Wang, Dominique Schols, Renato Tony Skerlj, David Earl Bogucki
  • Process for preparation of N-1 protected N ring nitrogen containing cyclic polyamines and products thereof
    Patent number: 6489472
    Abstract: Cyclic polyamines containing N nitrogens on the ring are protected with high yields in a N-1 manner, e.g. all protected but one amino group, by using certain fluoro-containing agents that offer easy deprotection. Preferably, a new process for preparing 1,1′-[1,4-phenylenebis (methylene)]-bis1,4,8,11-tetraazacyclotetradecane is disclosed.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: December 3, 2002
    Assignee: AnorMED, Inc.
    Inventors: Christen M. Giandomenico, Wen Yang
  • Pharmaceutical compositions comprising metal complexes
    Patent number: 6417182
    Abstract: New pharmaceutical compositions and pharmaceutical compositions comprising metal complexes have activity against diseases caused by or related to overproduction or localized high concentration of nitric oxide in the body.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: July 9, 2002
    Assignee: AnorMED Inc.
    Inventors: Michael J Abrams, Simon P Fricker, Barry A Murrer, Owen J Vaughan
  • Pt(IV) antitumor agent
    Patent number: 6413953
    Abstract: An improved platinum(IV) compound and its application as an antitumor agent are disclosed.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: July 2, 2002
    Assignee: AnorMED Inc.
    Inventors: Christen M. Gianomenico, Ernest S. Y. Wong
  • Methods to enhance white blood cell count
    Patent number: 6365583
    Abstract: Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: April 2, 2002
    Assignee: AnorMED, Inc.
    Inventors: Ronald Trevor MacFarland, Andrew W. Millar, Gary Bridger, Michael J. Abrams, Geoffrey W. Henson