Patents Assigned to ANTABIO SAS
  • Diazabicyclooctanones as inhibitors of serine beta-lactamases
    Patent number: 11905286
    Abstract: The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof: wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-?-lactamase enzymes, in combination with antibiotics.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: February 20, 2024
    Assignee: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies
  • COMBINATION THERAPY
    Publication number: 20240016941
    Abstract: The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2, R3, R4, n, Lk, (A), G and m are as defined herein. Also provided are therapeutic uses of such combinations and compositions in the treatment of conditions such as cystic fibrosis.
    Type: Application
    Filed: March 23, 2021
    Publication date: January 18, 2024
    Applicant: Antabio SAS
    Inventors: Martin Everett, Simon Leiris, David Thomas Davies, Nicolas Sprynski, Lilha Beyria, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, Richard Leonard Elliott, David Edward Clark
  • CHEMICAL COMPOUNDS
    Publication number: 20220315546
    Abstract: The invention relates to a compound which is a thiazole derivative of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, , Z, L, X, m, n and p are as defined herein. The compounds are useful in the treatment and prevention of bacterial infection. The invention also relates to combinations of the compound of Formula (I) with further active agents.
    Type: Application
    Filed: March 4, 2022
    Publication date: October 6, 2022
    Applicant: Antabio SAS
    Inventors: David Thomas DAVIES, Simon LEIRIS, Nicolas SPRYNSKI, Martin EVERETT, Magdalena ZALACAIN
  • DIAZABICYCLOOCTANONES AS INHIBITORS OF SERINE BETA-LACTAMASES
    Publication number: 20220289747
    Abstract: The invention relates to a compound which is a diazabicyclooctanone of Formula (I) or a pharmaceutically acceptable salt thereof (I): wherein R is as defined herein. The compounds are useful in the treatment of bacterial infection, in particular they are useful in reducing bacterial resistance to antibiotics. They are also useful in the treatment of bacteria which express serine-?-lactamase enzymes, in combination with antibiotics.
    Type: Application
    Filed: August 8, 2019
    Publication date: September 15, 2022
    Applicant: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies
  • INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
    Publication number: 20220112169
    Abstract: The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.
    Type: Application
    Filed: July 25, 2019
    Publication date: April 14, 2022
    Applicant: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies, Martin Everett, Nicolas Sprynski, Lilha Beyria, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, Richard Leonard Elliott, David Edward Clark
  • Chemical compounds
    Patent number: 11299467
    Abstract: The invention relates to a compound which is a thiazole derivative of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, Formula (A), Z, L, X, m, n and p are as defined herein. The compounds are useful in the treatment and prevention of bacterial infection. The invention also relates to combinations of the compound of Formula (I) with further active agents.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: April 12, 2022
    Assignee: ANTABIO SAS
    Inventors: David Thomas Davies, Simon Leiris, Nicolas Sprynski, Martin Everett, Magdalena Zalacain
  • INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
    Publication number: 20210347748
    Abstract: The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, n and p are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.
    Type: Application
    Filed: July 25, 2019
    Publication date: November 11, 2021
    Applicant: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies, Martin Everett, Nicolas Sprynski, Lilha Beyria, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, Richard Leonard Elliott, David Edward Clark
  • Chemical compounds as antibiotics
    Patent number: 11000511
    Abstract: The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: May 11, 2021
    Assignee: Antabio SAS
    Inventors: Simon Leiris, David Thomas Davies, Martin Everett, Nicolas Sprynski, Jonathan Mark Sutton, Michael Steven Bodnarchuk, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, David Edward Clark, Richard Leonard Elliott, Lilha Beyria
  • CHEMICAL COMPOUNDS
    Publication number: 20200339526
    Abstract: The invention relates to a compound which is a thiazole derivative of Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, Formula (A), Z, L, X, m, n and p are as defined herein. The compounds are useful in the treatment and prevention of bacterial infection. The invention also relates to combinations of the compound of Formula (I) with further active agents.
    Type: Application
    Filed: July 20, 2018
    Publication date: October 29, 2020
    Applicant: Antabio SAS
    Inventors: David Thomas DAVIES, Simon LEIRIS, Nicolas SPRYNSKI, Martin EVERETT, Magdalena ZALACAIN
  • CHEMICAL COMPOUNDS AS ANTIBIOTICS
    Publication number: 20200155509
    Abstract: The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.
    Type: Application
    Filed: March 21, 2018
    Publication date: May 21, 2020
    Applicant: Antabio SAS
    Inventors: Simon LEIRIS, David Thomas DAVIES, Martin EVERETT, Nicolas SPRYNSKI, Jonathan Mark SUTTON, Michael Steven BODNARCHUK, Thomas David PALLIN, Andrew Peter CRIDLAND, Toby Jonathan BLENCH, David Edward CLARK, Richard Leonard ELLIOTT, Lilha BEYRIA
  • Antibacterial thiazolecarboxylic acids
    Patent number: 9914712
    Abstract: Compounds of general formula (I): wherein R1, R11, Y, R2, n and A are as defined herein are useful as inhibitors or metallo-?-lactamase (MBL) enzymes and can be used for reducing or removing antibiotic resistance in bacteria.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: March 13, 2018
    Assignee: ANTABIO SAS
    Inventors: Marc Lemonnier, David Davies, Thomas David Pallin