Abstract: The present invention provides devices and methods for real time detection of target agents in a sample. These devices utilize tracking technology and selective binding to allow the identification of one or more target agents in a sample, and preferably in a biological sample. The present invention provides specific embodiments employing radio frequency identification devices.

Abstract: The present invention provides a device and methods for the detection and quantification of one or more target agents in a sample by rapid and specific electrochemical detection. The present invention includes kits, devices and compositions capable of performing rapid, specific and accurate detection of one or more target agents in a sample.

Abstract: The present invention provides microdevices for electrochemical detection of target agents in a fluid sample. The microdevices each comprise an elongated microstructure having an inlet for introduction of a fluid sample potentially containing a target agent, and an outlet to allow the sample to flow through the region of the microdevice that allows detection of the target agent. This detection is mediated through hybridization of nucleic acids corresponding to a target agent with device-associated nucleic acids and subsequent binding of an electrochemical detection agent to allow the transfer of an electron to or from the electrode. In specific embodiment, the device comprises: a hollow elongated microstructure with a conductive surface on the internal surface; b) insulating polymer that is uniformly distributed on the conductive surface; c) adapter molecule associated with the insulating polymer, and d) a plurality of associated nucleic acids conjugated to the polymer surface in a specific orientation.

Abstract: The present invention provides electrochemical detection devices useful for conducting diagnostic tests. The devices of the present invention can be used to detect a wide range of target agents, and is useful in analyzing biological samples (including blood and other bodily fluids), as well as air, water, soil and other environmental samples.

Abstract: The present invention provides a methods and compositions for early diagnosis of cancer by rapid and specific detection of one or more cancer markers in a sample.

Abstract: The present invention provides apparatus and methods of use thereof for rapidly and specifically detecting target agents.