Abstract: The present invention provides a process for the synthesis of Plecanatide, a guanylate cyclase agonist. The process involves convergent synthesis with compounds, i.e., fragment of peptides followed by cyclization. The method provides high yield of Plecanatide with less impurities.
Abstract: The present disclosure relates to polymorphic form of PQQ and/or its salts represented by formula (I), wherein “n” and “m” are selected from a group consisting of: (a) “n”=3, “m”=0 and (b) “n”=1, “m”=2; and; R3 is Na+. The present disclosure also relates to a process for preparing the polymorphic form of compound of formula (I) and/or its salts, a composition comprising the polymorphic form of compound of formula (I) and/or its salts and use thereof.
Type:
Application
Filed:
April 15, 2015
Publication date:
January 26, 2017
Applicant:
ANTHEM BIOSCIENCES PRIVATE LIMITED
Inventors:
RAJULU GAVARA GOVINDA, GANESH SAMBASIVAM, TOM THOMAS PUTHIAPARAMPIL, RAVINDRA CHANDRAPPA KORAMANGALA