Abstract: The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. a judiciously chosen photosensitizer), and their use for the selective light-mediated occlusion of new blood vessels.
Type:
Application
Filed:
April 28, 1999
Publication date:
March 6, 2003
Applicant:
ANTHONY J. ZELANO
Inventors:
DARIO NERI, LORENZO TARLI, FRANCESCA VITI, MANFRED BIRCHLER