Patents Assigned to Antibioticos S.A.
  • Process for the production of daptomycin
    Patent number: 8313922
    Abstract: The present invention relates to an improved process for the production of Daptomycin by fermentation with Streptomyces roseosporus, in the presence of n-decanal or Cuphea oil as sources of the n-decanoyl side chain. These reagents allow to reduce toxicity effects on the bacteria and to avoid the use of solvents in the feeding solution.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: November 20, 2012
    Assignee: Antibioticos S.p.A.
    Inventors: Gianluca Bertetti, Antonella Malcangi, Roberto Muraca, Guido Trione, Alessia Rossi
  • Crystalline irinotecan hydrochloride and methods for its preparation
    Patent number: 8247426
    Abstract: Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: August 21, 2012
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • CRYSTALLINE IRINOTECAN HYDROCHLORIDE AND METHODS FOR ITS PREPARATION
    Publication number: 20100179180
    Abstract: Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
    Type: Application
    Filed: November 10, 2009
    Publication date: July 15, 2010
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni POZZI, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • PROCESS FOR THE PRODUCTION OF DAPTOMYCIN
    Publication number: 20100047873
    Abstract: The present invention relates to an improved process for the production of Daptomycin by fermentation with Streptomyces roseosporus, in the presence of n-decanal or Cuphea oil as sources of the n-decanoyl side chain. These reagents allow to reduce toxicity effects on the bacteria and to avoid the use of solvents in the feeding solution.
    Type: Application
    Filed: July 30, 2009
    Publication date: February 25, 2010
    Applicant: ANTIBIOTICOS S.p.A
    Inventors: Gianluca BERTETTI, Antonella Malcangi, Roberto Muraca, Guido Trione, Alessia Rossi
  • Crystalline Polymorphs of Topotecan Hydrochloride and Methods for the Preparation Thereof
    Publication number: 20090192184
    Abstract: The invention relates to two novel crystalline form of Topotecan hydrochloride (Ia) Herein referred to as forms ? and ?, characterized by high purity and whose preparation is advantageous from the industrial point of view. Form ? can be in fact conveniently prepared starting from 10-hydroxy-camptothecin, whereas form ? can be prepared starting from form ?.
    Type: Application
    Filed: December 3, 2008
    Publication date: July 30, 2009
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Andrea Mazzoni, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • INTERMEDIATE CEFDINIR SALTS
    Publication number: 20090036672
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and B are as defined in the description and methods for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.
    Type: Application
    Filed: July 29, 2008
    Publication date: February 5, 2009
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Intermediate cefdinir salts
    Patent number: 7405294
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and B are defined in the description. These salts are useful intermediates for the preparation of cefdinir. Also, disclosed are processes for the preparation thereof from the compounds of the general formula (II) and (III). Further, disclosed is a method of producing cefdinir from the salts of the general formula (I) including the steps of removing protecting groups.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 29, 2008
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Cephalosporin C acylases
    Patent number: 7399624
    Abstract: Enzymes with cephalosporin C acylase activity obtained by site-directed, random or “site-saturation” mutagenesis of a native sequence optimised for expression in E. coli.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: July 15, 2008
    Assignee: Antibioticos S.p.A.
    Inventors: Loredano Pollegioni, Mirella Pilone, Gianluca Molla, Eugenio Cucchetti, Roberto Verga, Walter Cabri
  • Process for the Purification of Tacrolimus
    Publication number: 20080160586
    Abstract: A process for the purification and recovery of Tacrolimus (I) (17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methyvinyl]-23,25- dimethoxy-13,19,21,27-tetramethyl-11,28-dioxi-4-azatricyclo-[22.3.1.04.9]octacos-18-en-2,3,10,16-tetraone), starting from Streptomyces sp fermentation broth. The process is particularly advantageous in terms of productivity and selectivity of the separation of impurities.
    Type: Application
    Filed: October 24, 2005
    Publication date: July 3, 2008
    Applicant: Antibioticos S.p.A.
    Inventors: Walter Cabri, Paolo Paissoni, Jacopo Roletto, Luca Morra
  • Purification of Tacrolimus on Supports of Vegetable Origin
    Publication number: 20080161555
    Abstract: The invention relates to a process for the purification of tacrolimus comprising contacting crude tacrolimus with a silver salt dissolved in a water/organic solvent mixture and with a carrier of vegetable origin, separating the mixture from the carrier and recovering purified tacrolimus.
    Type: Application
    Filed: July 10, 2006
    Publication date: July 3, 2008
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Luca Morra, Jacopo Roletto, Giovanni Lazzari, Walter Cabri, Paolo Paissoni
  • Epoxidation of 17-oxo-15,16-Methylene Steroids with Sulfoxonium Ylides
    Publication number: 20080076915
    Abstract: A process for the epoxidation of 17-oxo-15,16-methylene steroids, in particular of drospirenone precursors, comprising the use of sulfoxonium ylides, in particular of dimethylsulfoxonium methyl ylide. The process allows to prepare in good yields 17-spiro epoxides, which can be easily transformed into 17-spironolacto-steroids.
    Type: Application
    Filed: September 21, 2007
    Publication date: March 27, 2008
    Applicant: ANTIBIOTICOS S.P.A.
    Inventors: Walter Cabri, Fabio Benedetti, Marco Alpegiani, Manuela Rodriquez, Cinzia Bottai
  • Method of production of ?-carotene by fermentation in mixed culture using (+) and (?) strains of
    Patent number: 7252965
    Abstract: The invention consists of fermenting selected strains of Blakeslea trispora in conditions such that ?-carotene is produced in the form of stabilized preparations with residual contents of other carotenoids (?-carotene and ?-zeacarotene). The fermentation conditions chosen include the programmed addition of oxygen and/or ?-ionone during fermentation, and control of the age of the vegetative growth phases of the strains employed. The ?-carotene obtained can be used in the pharmaceutical and food sectors.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: August 7, 2007
    Assignee: Antibioticos, S.A.U.
    Inventors: Javier Costa Perez, Ana Teresa Marcos Rodríguez, Juan Luis De La Fuente Moreno, Marta Rodríguez Saiz, Bruno Diez Garcia, Enrique Peiro Cezon, Walter Cabri, José Luis Barredo Fuente
  • Crystalline cefdinir salts
    Patent number: 7173126
    Abstract: Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir are herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatment with phosphoric acid.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: February 6, 2007
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Intermediate cefdinir salts
    Publication number: 20060111566
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and as defined in the description and a process for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.
    Type: Application
    Filed: September 26, 2003
    Publication date: May 25, 2006
    Applicant: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martinez Gomez, Marco Alpegiani, Walter Cabri
  • Crystalline cefdinir salts
    Publication number: 20060074236
    Abstract: Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir is herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatement with phosphoric acid.
    Type: Application
    Filed: December 1, 2003
    Publication date: April 6, 2006
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Process for the synthesis of pergolide
    Patent number: 7019140
    Abstract: A process for the synthesis of pergolide (Formula (I)) (D-6-n-propyl-8?methylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from the yield and safety standpoint.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: March 28, 2006
    Assignee: Antibioticos S.p.A.
    Inventors: Walter Cabri, Paolo Paissoni, Jacopo Roletto, Piera Fonte, Sara Olmo
  • Process for the synthesis of thalidomide
    Publication number: 20050272934
    Abstract: The invention relates to a process for the preparation of thalidomide (I) comprising the reaction between glutamine (II) and a phthaloylating agent, preferably phthalic anhydride, to give N-phthaloyl-glutamine, which is directly transformed in thalidomide.
    Type: Application
    Filed: May 31, 2005
    Publication date: December 8, 2005
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Marco Alpegiani, Andrea Mazzoni, Domenico Vergani, Walter Cabri
  • Cephalosporin C acylases
    Publication number: 20050158818
    Abstract: Enzymes with cephalosporin C acylase activity obtained by site-directed, random or “site-saturation” mutagenesis of a native sequence optimised for expression in E. coli.
    Type: Application
    Filed: January 11, 2005
    Publication date: July 21, 2005
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Loredano Pollegioni, Mirella Pilone, Gianluca Molla, Eugenio Cucchetti, Roberto Verga, Walter Cabri
  • Process for the preparation of anthracycline derivatives
    Patent number: 6844455
    Abstract: The present invention discloses a process for the semi-synthesis of 4-demethoxydaunomycinone, (8s-cis)-acetyl-10-hydroxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-5,12-naphthacenedione, of formula (I).
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: January 18, 2005
    Assignee: Antibioticos S.p.A.
    Inventors: Valentina Pizzamiglio, Walter Cabri, Elio Mapelli
  • Process for the synthesis of beta-lactam derivatives
    Patent number: 6642378
    Abstract: The invention is directed towards a process for the preparation of Cefuroxime acid or for a corresponding pharmaceutically acceptable salt or ester. The process comprises the carbamoylation of a Cefuroxime precursor with an activated isocyanate. Additionally, the process is characterized by the fact that a carbonic C1-C4 alkyl ester is used as a solvent for the carbamoylation reaction.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: November 4, 2003
    Assignee: Antibioticos S.p.A.
    Inventors: Walter Cabri, Enrico Siviero, Paola Luigia Daverio, Tania Cristiano, Claudio Felisi, Davide Longoni