Abstract: The present invention relates to a receptor binding conjugate which consists of an antibody, a radionuclide and folate or a folate derivative, wherein or not the conjugate possesses dual binding ability. The present invention also relates to a method and a kit to prepare, as well as a method to use, such conjugates.
Furthermore, the use of a conjugate according to the present invention to prepare a pharmaceutical solution is disclosed.
Abstract: Processes for the preparation, prepared solutions, and the use of radium-223 for the treatment of calcified tumors, bone tumors, treatment of bones, bone surfaces and soft tissues is described.
Type:
Grant
Filed:
January 3, 2000
Date of Patent:
October 21, 2003
Assignee:
Anticancer Therapeutic Inventions AS
Inventors:
Roy H. Larsen, Gjermund Henriksen, Øyvind S. Bruland
Abstract: The present invention relates to a conjugator system comprising liposomes with ionophores, and with chelator solution and alpha-particle emitting radionuclide(s) located inside of the liposome. Furthermore, a the method for the preparation of this type of radioactive liposomes is described, as well as use of the system and a kit for preparing the system.