Abstract: The stem cell (1) includes a cellular DNA (2) comprising a plurality of sequences coding different genes and promoters allowing DNA-protein-interactions, at least one protein molecule (3) generated by means of a specific stimulus (12) and at least one DNA-molecule (6) artificially introduced into the stem cell (1). The artificially introduced DNA-molecule (6) comprises at least one binding site sequence (30) being apt to interact with the protein molecule (3), at least one DNA-sequence (40) coding an indicator molecule (5) and at least one minimal promoter sequence (50), allowing the gene expression of said indicator molecule (5), whereby the stem cell further includes at least one indicator molecule (5) having properties allowing its identification and is produced by synthesis of the DNA-sequence (40) coding an indicator molecule (5) of the artificially introduced DNA-molecule (6).
Abstract: The stem cell (1) includes a cellular DNA (2) comprising a plurality of sequences coding different genes and promoters allowing DNA-protein-interactions, at least one protein molecule (3) generated by means of a specific stimulus (12) and at least one DNA-molecule (6) artificially introduced into the stem cell (1). The artificially introduced DNA-molecule (6) comprises at least one binding site sequence (30) being apt to interact with the protein molecule (3), at least one DNA-sequence (40) coding an indicator molecule (5) and at least one minimal promoter sequence (50), allowing the gene expression of said indicator molecule (5), whereby the stem cell further includes at least one indicator molecule (5) having properties allowing its identification and is produced by synthesis of the DNA-sequence (40) coding an indicator molecule (5) of the artificially introduced DNA-molecule (6).
Abstract: In this method for cementing an implant into bone by means of an autopolymerising two-component bone cement the implant, in particular the stem of a hip prosthesis is preheated above room-temperature prior to its cementing into bone, preferably to at least 43.degree. C.By this method the stem-cement interface is warmer than the bone-cement interface and consequently a stiff cement shell will form first around the stem and the cement will shrink towards the stem and away from the bone. The resulting reduction of porosity at the stem-cement interface improves significantly the fatigue life of the system.
Abstract: The femoral component for a hip joint prosthesis has an intramedullary stem having a free distal region, a proximal region extending to a neck for receiving a ball head, a medial side and a lateral side.The stem has screw holes extending from said lateral side to said medial side for receiving bone screws in the lateral to medial direction for fixation of said stem to the medial cortex. The stem is coupled primarily to the medial cortex of the femur and only secondarily to the cancellous portion of the proximal femur to aid the rotational (torsional) stability of the implant.
Abstract: A stem for an endoprosthesis to be anchored in a bone (3) comprises a chamber (4) which surrounds the stem periprosthetically, which can be sealed in a pressure tight manner and which can be expanded with a thermoplastic or thermostable filling material (16). The rigid stem (1) of the endoprosthesis is connected mechanically to the bone (3) via the expandable chamber (4) by means of the filling material (16). The filling material is isolated from the bone (3), however, by the wall of the pressure-tight chamber (4). This makes it possible to ensure that the outer wall of the chamber (4) adjacent to the bone is extremely biocompatible.
Abstract: The scissors are provided with replaceable thin insert blades. The blade insert carriers of the scissors are recessed to receive the blade inserts fixed in place by a screw. The edge-to-edge force at the cutting point is controlled by the bend and the twist of the blade insert carriers. The fixation of the blade inserts by the screw in the front half of the blade insert carriers and their twist in the back section, leaves the cutting edge of the blade inserts unsupported near the pivot point of the scissors. Torsion of the blade inserts allows for easier control of the edge-to-edge force near the pivot without a penalty of the high edge-to-edge compliance towards the tips. Use of replaceable blade inserts eliminates the need for resharpening of the cutting edge and allows for use of the special purpose blade inserts with the same basic scissors.