Patents Assigned to AorTech International PLC
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Patent number: 10730994Abstract: The present invention provides silicon-based polycarbonates, processes for their preparation and their use in the synthesis of copolymers, in particular segmented copolymers such as polyurethanes for biomedical applications.Type: GrantFiled: June 8, 2016Date of Patent: August 4, 2020Assignee: Aortech International plcInventors: Francis P. Maguire, Sriram Venkataramani
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Patent number: 10676560Abstract: The present invention relates to a biostable polyurethane or polyurea comprising: (a) a soft segment comprising a polysiloxane of the general formula (I); and (b) greater than 0 and less than 40 wt % of a hard segment which is a reaction product of a diisocyanate and a linear difunctional chain extender, processes for their preparation and their use in the manufacture of biomaterials, devices, articles or implants.Type: GrantFiled: May 31, 2018Date of Patent: June 9, 2020Assignee: Aortech International plcInventor: Ajay D. Padsalgikar
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Patent number: 10655012Abstract: The present invention provides silicon-based polycarbonates, processes for their preparation and their use in the synthesis of copolymers, in particular segmented copolymers such as polyurethanes for biomedical applications.Type: GrantFiled: June 8, 2016Date of Patent: May 19, 2020Assignee: Aortech International plcInventors: Francis P. Maguire, Sriram Venkataramani
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Patent number: 10597497Abstract: The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of a soft tissue implant such as breast implants and the repair of orthopaedic joints such as spinal discs.Type: GrantFiled: August 6, 2018Date of Patent: March 24, 2020Assignee: Aortech International plcInventors: Mansour Mehrabi, Sriram Venkataramani, Mark Bown, Ajay D. Padsalgikar, Ramasri Mudumba
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Patent number: 10195834Abstract: The invention relates to a process for bonding a silicone or silicone based material to a polyurethane and use of the bonded silicone-polyurethane in the manufacture of biomaterials, devices, articles or implants, in particular long term implantable medical devices in the fields of cardiology, orthopedics, plastic surgery and gastroenterology. The process involves the steps of (a) flame treating a surface of the silicone or silicone based material and (b) bonding the polyurethane to the flame treated surface of the silicone or silicone based material.Type: GrantFiled: November 6, 2017Date of Patent: February 5, 2019Assignee: Aortech International plcInventor: Ajay D. Padsalgikar
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Patent number: 10059807Abstract: The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of a soft tissue implant such as breast implants and the repair of orthopedic joints such as spinal discs.Type: GrantFiled: July 7, 2016Date of Patent: August 28, 2018Assignee: Aortech International plcInventors: Mansour Mehrabi, Sriram Venkataramani, Mark Bown, Ajay D. Padsalgikar, Ramasri Mudumba
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Patent number: 9994668Abstract: The present invention relates to a biostable polyurethane or polyurea comprising: (a) a soft segment comprising a polysiloxane of the general formula (I); and (b) greater than O and less than 40 wt % of a hard segment which is a reaction product of a diisocyanate and a linear difunctional chain extender, processes for their preparation and their use in the manufacture of biomaterials, devices, articles or implants.Type: GrantFiled: December 2, 2016Date of Patent: June 12, 2018Assignee: Aortech International plcInventor: Ajay D. Padsalgikar
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Patent number: 9809016Abstract: The invention relates to a process for bonding a silicone or silicone based material to a polyurethane and use of the bonded silicone-polyurethane in the manufacture of biomaterials, devices, articles or implants, in particular long term implantable medical devices in the fields of cardiology, orthopaedics, plastic surgery and gastroenterology. The process involves the steps of (a) flame treating a surface of the silicone or silicone based material and (b) bonding the polyurethane to the flame treated surface of the silicone or silicone based material.Type: GrantFiled: June 28, 2016Date of Patent: November 7, 2017Assignee: Aortech International plcInventor: Ajay D. Padsalgikar
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Patent number: 9765191Abstract: The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of a soft tissue implant such as breast implants and the repair of orthopaedic joints such as spinal discs.Type: GrantFiled: January 6, 2014Date of Patent: September 19, 2017Assignee: Aortech International plcInventors: Mansour Mehrabi, Sriram Venkataramani, Mark Bown, Ajay D. Padsalgikar, Ramasri Mudumba
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Publication number: 20170114187Abstract: The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of a soft tissue implant such as breast implants and the repair of orthopaedic joints such as spinal discs.Type: ApplicationFiled: January 6, 2014Publication date: April 27, 2017Applicant: Aortech International plcInventors: Mansour Mehrabi, Sriram Venkataramani, Mark Bown, Ajay D. Padsalgikar, Ramasri Mudumba
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Patent number: 9512261Abstract: The present invention relates to a biostable polyurethane or polyurea comprising: (a) a soft segment comprising a polysiloxane of the general formula (I); and (b) greater than O and less than 40 wt % of a hard segment which is a reaction product of a diisocyanate and a linear difunctional chain extender, processes for their preparation and their use in the manufacture of biomaterials, devices, articles or implants.Type: GrantFiled: September 11, 2015Date of Patent: December 6, 2016Assignee: Aortech International plcInventor: Ajay D. Padsalgikar
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Patent number: 9421737Abstract: The invention relates to a process for bonding a silicone or silicone based material to a polyurethane and use of the bonded silicone-polyurethane in the manufacture of biomaterials, devices, articles or implants, in particular long term implantable medical devices in the fields of cardiology, orthopedics, plastic surgery and gastroenterology. The process involves the steps of (a) flame treating a surface of the silicone or silicone based material and (b) bonding the polyurethane to the flame treated surface of the silicone or silicone based material.Type: GrantFiled: December 3, 2015Date of Patent: August 23, 2016Assignee: Aortech International plcInventor: Ajay D. Padsalgikar
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Patent number: 9216558Abstract: The invention relates to a process for bonding a silicone or silicone based material to a polyurethane and use of the bonded silicone-polyurethane in the manufacture of biomaterials, devices, articles or implants, in particular long term implantable medical devices in the fields of cardiology, orthopaedics, plastic surgery and gastroenterology. The process involves the steps of (a) flame treating a surface of the silicone or silicone based material and (b) bonding the polyurethane to the flame treated surface of the silicone or silicone based material.Type: GrantFiled: April 26, 2012Date of Patent: December 22, 2015Assignee: Aortech International plcInventor: Ajay D. Padsalgikar
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Patent number: 9175130Abstract: The present invention relates to a biostable polyurethane or polyurea comprising: (a) a soft segment comprising a polysiloxane of the general formula (I); and (b) greater than O and less than 40 wt % of a hard segment which is a reaction product of a diisocyanate and a linear difunctional chain extender, processes for their preparation and their use in the manufacture of biomaterials, devices, articles or implants.Type: GrantFiled: March 17, 2014Date of Patent: November 3, 2015Assignee: Aortech International plcInventor: Ajay D. Padsalgikar
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Publication number: 20140343243Abstract: The present invention relates to a biostable polyurethane or polyurea comprising: (a) a soft segment comprising a polysiloxane of the general formula (I); and (b) greater than O and less than 40 wt % of a hard segment which is a reaction product of a diisocyanate and a linear difunctional chain extender, processes for their preparation and their use in the manufacture of biomaterials, devices, articles or implants.Type: ApplicationFiled: March 17, 2014Publication date: November 20, 2014Applicant: Aortech International plcInventor: Ajay D. Padsalgikar
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Patent number: 8882832Abstract: The invention relates to an implantable prosthesis and a shell for an implantable prosthesis and methods for making them, in particular a light weight implantable prosthesis containing a biocompatible filler which is suitable for use as a breast implant.Type: GrantFiled: July 25, 2012Date of Patent: November 11, 2014Assignee: Aortech International plcInventors: Ajay D. Padsalgikar, Frank Maguire, Sriram Venkataramani
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Publication number: 20140323676Abstract: The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of a soft tissue implant such as breast implants and the repair of orthopaedic joints such as spinal discs.Type: ApplicationFiled: January 6, 2014Publication date: October 30, 2014Applicant: Aortech International plcInventors: Mansour Mehrabi, Sriram Venkataramani, Mark Bown, Ajay D. Padsalgikar, Ramasri Mudumba
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Patent number: 8801993Abstract: This invention relates to electrical devices that are implantable inside an animal, including humans. The invention particularly relates to polyurethane headers mounted on the electrical devices to house electrical contacts. The polyurethane headers are formed by (a) mixing (i) a prepolymer comprising a silicon-containing diol of formula (I) in which R1, R2, R3 and R4 are independently selected from C1-6alkyl; R5 and R6 are independently selected from C1-6alkylene; R7 is C1-6alkylene, O, S or NR in which R is H or C1-6alkyl; and n is 1 to 3 and a diisocyanate; and (ii) a C2-12alkanediol; (b) injecting the mixture of the prepolymer and the C2-12alkanediol into a mold having a cavity shaped to form a header; (c) allowing the mixture to cure and form a polyurethane header within the mold; and (d) releasing the formed polyurethane header from the mold.Type: GrantFiled: October 22, 2010Date of Patent: August 12, 2014Assignee: Aortech International plcInventors: Ajay D. Padsalgikar, Elenora Stepanova, Richard Anup D'Mello, Jadwiga Weksler
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Patent number: 8674035Abstract: The present invention relates to a biostable polyurethane or polyurea comprising: (a) a soft segment comprising a polysiloxane of the general formula (I); and (b) greater than O and less than 40 wt % of a hard segment which is a reaction product of a diisocyanate and a linear difunctional chain extender, processes for their preparation and their use in the manufacture of biomaterials, devices, articles or implants.Type: GrantFiled: March 29, 2007Date of Patent: March 18, 2014Assignee: Aortech International plcInventor: Ajay Padsalgikar
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Patent number: 8216631Abstract: A cardiac valve prosthesis having a frame and two or more leaflets (preferably three) attached to the frame. The leaflets are attached to the frame between posts, with a free edge which can seal the leaflets together when the valve is closed under back pressure. The leaflets are created in a mathematically defined shape allowing good wash-out of the whole leaflet orifice, including the area close to the frame posts, thereby relieving the problem of thrombus deposition under clinical implant conditions.Type: GrantFiled: November 4, 2010Date of Patent: July 10, 2012Assignee: Aortech International PLCInventors: Bernard O'Connor, David John Wheatley, Gillian Maureen Bernacca, William Stafford Haworth