Patents Assigned to A.P. Pharma, Inc.
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Publication number: 20140142131Abstract: Long acting injectable analgesic formulations and methods for providing long lasting pain relief in animals are disclosed.Type: ApplicationFiled: November 8, 2013Publication date: May 22, 2014Applicant: A.P. PHARMA, INC.Inventors: Peter Hanson, Joseph K. Rosentel, John Barr
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Publication number: 20140107226Abstract: Disclosed herein are methods of enhancing the stability of a sustained pharmaceutical composition comprising an active agent and a polymer and methods of preparing such pharmaceutical compositions with enhanced stability.Type: ApplicationFiled: December 18, 2013Publication date: April 17, 2014Applicant: A.P. PHARMA, INC.Inventors: Devang T. Shah, John Barr
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Publication number: 20120283253Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: ApplicationFiled: July 18, 2012Publication date: November 8, 2012Applicant: A.P. PHARMA, INC.Inventors: Steven Y. NG, Hui-Rong Shen, Jorge Heller
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Patent number: 8252306Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: GrantFiled: October 24, 2011Date of Patent: August 28, 2012Assignee: A.P. Pharma, Inc.Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
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Patent number: 8252304Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: GrantFiled: September 22, 2009Date of Patent: August 28, 2012Assignee: A. P. Pharma, Inc.Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
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Publication number: 20120041021Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: ApplicationFiled: October 24, 2011Publication date: February 16, 2012Applicant: A.P. PHARMA, INC.Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
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Publication number: 20120041020Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: ApplicationFiled: October 24, 2011Publication date: February 16, 2012Applicant: A.P. PHARMA, INC.Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
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Patent number: 7456213Abstract: This invention relates to graft copolymer delivery vehicles comprising a polyethyleneglycol-poly(ortho ester), and to controlled release pharmaceutical compositions comprising the delivery vehicle and an active agent. The graft copolymer delivery vehicles may be thermogels graft copolymers. The pharmaceutical compositions may be in the form of a topical, syringable, or injectable formulation for local controlled delivery of the active agent.Type: GrantFiled: March 28, 2006Date of Patent: November 25, 2008Assignee: A.P. Pharma, Inc.Inventor: Jorge Heller
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Patent number: 7220414Abstract: Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribution profiles, and degrade readily in low pH conditions. Conjugates of the polymers with drugs, especially anticancer drugs, and methods of treatment of cancer.Type: GrantFiled: September 6, 2001Date of Patent: May 22, 2007Assignee: A.P. Pharma, Inc.Inventors: Stephen J. Brocchini, Jorge Heller, Ryan Tomlinson, Ruth Duncan, Shane Garrett, Marcus M. Klee
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Patent number: 7163694Abstract: Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block copolymers contain these bioerodible poly(ortho esters). These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.Type: GrantFiled: March 8, 2006Date of Patent: January 16, 2007Assignee: A.P. Pharma, Inc.Inventors: Jorge Heller, Steven Y. Ng
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Patent number: 7045589Abstract: Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block copolymers contain these bioerodible poly(ortho esters). These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.Type: GrantFiled: November 15, 2002Date of Patent: May 16, 2006Assignee: A.P. Pharma, Inc.Inventors: Jorge Heller, Steven Y. Ng
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Patent number: 6946145Abstract: Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.Type: GrantFiled: July 24, 2003Date of Patent: September 20, 2005Assignee: A.P. Pharma, Inc.Inventors: Steven Y. Ng, Jorge Heller
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Patent number: 6863782Abstract: Di(ketene acetals) are prepared by photoisomerizing the corresponding di(vinyl acetals).Type: GrantFiled: November 15, 2002Date of Patent: March 8, 2005Assignee: A.P. Pharma, Inc.Inventors: Peter W. Newsome, A. Roger Frisbee, Zinovy Itov, April J. Morgan, Robert A. Noe
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Patent number: 6861068Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: GrantFiled: January 26, 2004Date of Patent: March 1, 2005Assignee: A.P. Pharma, Inc.Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
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Publication number: 20050042194Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: ApplicationFiled: September 28, 2004Publication date: February 24, 2005Applicant: A.P. PHARMA, INC.Inventors: Steven Ng, Hui Shen, Jorge Heller
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Patent number: 6670335Abstract: Oil-in-water emulsion formulations contain both free fluorouracil and fluorouracil impregnated in porous microparticles. The formulations are suitable for topical administration, and are useful for the treatment of solar keratoses, actinic keratoses, and superficial basal cell carcinomas.Type: GrantFiled: March 5, 2001Date of Patent: December 30, 2003Assignee: A. P. Pharma, Inc.Inventors: B. Sandhya Singh, Subhash J. Saxena
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Patent number: 6667371Abstract: Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.Type: GrantFiled: November 14, 2002Date of Patent: December 23, 2003Assignee: A.P. Pharma, Inc.Inventors: Steven Y. Ng, Jorge Heller
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Patent number: 6613355Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: GrantFiled: May 11, 2001Date of Patent: September 2, 2003Assignee: A.P. Pharma, Inc.Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
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Patent number: 6497896Abstract: A method for administering a camptothecin to a patient comprising: injecting into a patient a pharmaceutical composition comprising an aqueous suspension of microdroplets suitable for intravenous delivery, the microdroplets having a mean diameter between 200 Angstroms and one micron, the microdroplets comprising a substantially water-insoluble, pharmacologically acceptable liquid, a camptothecin dissolved in the water-insoluble, pharmacologically acceptable liquid, and an outer layer comprising a phospholipid. The pharmaceutical composition is particularly well suited for delivering camptothecins, particularly 9-nitro-camptothecin intravenously.Type: GrantFiled: February 12, 2001Date of Patent: December 24, 2002Assignees: SuperGen, Inc., R T P Pharma Inc.Inventors: Howard Sands, Awadhesh Mishra