Abstract: The present disclosure generally relates to technologies for the degradation a systemic toxin in vivo by enhancing the metabolic functionality of the lungs. Such technologies comprise introducing, to pulmonary tissue of a subject, a composition comprising at least one enzyme known to enzymatically break down at least one toxin present systemically in the subject. The provided technologies enable the lung to behave as a tunable metabolic organ, facilitating the removal of toxins from the systemic circulation of a subject, such as a subject having a condition resulting in the toxic accumulation or an endogenous metabolite, and a subject who has consumed a toxic substance.

Abstract: The present disclosure generally relates to technologies for cleansing at least a portion of a lung of a subject (e.g., from at least one alcoholic irritant) and methods of freshening the breath of a subject. Such technologies comprise introducing, to at least a portion of a lung of a subject, a composition comprising at least one enzyme known to enzymatically break down at least one alcoholic irritant present systemically in the subject, including in at least a portion of said lung.