Patents Assigned to APG Therapeutics, Inc.
  • Polyethylenimine (PEI)-polypeptide conjugates and methods of use thereof
    Patent number: 11103589
    Abstract: The present application provides PEI compounds comprising a linker, PEI-polypeptide conjugates (e.g., PEI-antibody conjugates), and complexes thereof comprising a biologically active molecule. Methods of preparing and using the compounds, conjugates and complexes are further provided. The PEI-polypeptide conjugates and complexes are useful for delivering biologically active molecules to the cytoplasm of cells and promoting release of the biologically active molecules from the endo-lysosomal pathway.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: August 31, 2021
    Assignee: APG Therapeutics, Inc.
    Inventors: Joaquim Trias, Jaume Pons, David Shelton, Antoni Planas