Abstract: This invention relates to methods for and products from precision manufacturing targeted nanoencapsulated drugs in a microgravity environment utilizing green, environmental-friendly SuperFluids™. Based on these methods, nanoparticles formulation of molecules such as, but not limited to, Bryostatin-1 and other Bryoids, manufactured and lyophilized in a gravity-based environment, will be smaller and more uniform with a higher surface area to volume ratio, approaching ‘picometer dimensions’ in a microgravity environment. Once frozen in Space, these enhanced nanoparticles, ‘picoparticles’ approaching ‘picometer dimensions’ will also find utility on Earth to treat ‘orphan’ and chronic diseases such as cancer, HIV and Alzheimer's disease. The methods feature SuperFluids™ which are supercritical, critical and near-critical fluids with and without polar cosolvents.