Abstract: Delayed-release formulation intended for administration by parenteral injection, consisting of solid calibrated microspheres (5-300 .mu.m) comprising a pharmaceutically active substance (for example: morphine) contained in spherical structures determined by one or more which are pharmacologically inactive carrier substances (for example: cholesterol), naturally present in the receiving organism, which are pharmacodynamically inactive at the administered doses of said dosage form, having a melting point greater than 60.degree. C. and stable in the solid state in the receiving physiological medium. The dosage form makes it possible to slow and prolong the effect of active substances which are too rapidly soluble in physiological medium (which act on the central nervous or neurovegetative system, such as vasedilators, anti-histaminics, hormones, contraceptives and the like).
Abstract: Formulations of programmed-release medicinal products intended for parenteral administration by injection, comprising calibrated solid microspheres (1 to 300 microns) of active substances. Provided in this form, steroids (for example progesterone and 17-.beta.-estradiol) may constitute injectable contraceptives, and the action of drugs having an approximatively 24 hours lasting effect may be regulated and extended.
Type:
Grant
Filed:
April 15, 1996
Date of Patent:
May 27, 1997
Assignee:
Aplicaciones Farmaceuticas S.A. de C.V.
Inventors:
Josue Garza Flores, Laura P. Laiseca Soto, Jose Guillen Pichardo, Juan Angeles Uribe
Abstract: Formulations of programmed-release medicinal products intended for parenteral administration by injection, comprising calibrated solid microspheres (1 to 300 microns) of active substances. Provided in this form, steroids (for example progesterone and 17-.beta.-estradiol) may constitute injectable contraceptives, and the action of drugs having an approximatively 24 hours lasting effect may be regulated and extended.
Type:
Grant
Filed:
May 17, 1994
Date of Patent:
April 30, 1996
Assignee:
Aplicaciones Farmaceuticas S.A. de C.V.
Inventors:
Josue Garza Flores, Laura P. Laiseca Soto, Jose Guillen Pichardo, Juan Angeles Uribe