Patents Assigned to Aplodan Formulations Ltd.
  • Increasing ATP availability by inhibition of creatine kinase (CK) leakage resulting from high-intensity exercise
    Patent number: 7375097
    Abstract: The present invention relates to a method of increasing Adenosine Triphosphate levels in a mammal wherein 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid inhibits the leakage of the Adenosine Triphosphate-dependant enzyme Creatine Kinase. Via the inhibition of Creatine Kinase leakage, Adenosine Triphosphate is not utilized in the conversion of creatine to phosphocreatine, thereby making it available for use in muscular contractions. The increase in availability leads to longer endurance and more forceful muscular contractions.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: May 20, 2008
    Assignee: Aplodan Formulations Ltd.
    Inventors: James D. Ramsbottom, Jason R. Peters, Shan Chaudhuri
  • Method of increasing intracellular concentrations of phosphate and increasing the force of muscular contractions
    Patent number: 7368441
    Abstract: The present invention relates to a method of increasing the intracellular concentration of phosphate by employing 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid as vehicle and method to transport Phosphate into the cell. The increase in intracellular phosphate increases the availability of Adenosine Triphosphate and phosphocreatine, thereby leading to an increase in the anaerobic energy supply resulting in longer endurance and more forceful muscular contractions.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: May 6, 2008
    Assignee: Aplodan Formulations Ltd.
    Inventors: James D. Ramsbottom, Jason R. Peters, Shan Chaudhuri
  • COMPOSITION AND METHOD FOR INCREASING LEAN MUSCLE MASS, DECREASING MUSCLE LOSS, INCREASING MUSCLE STRENGTH AND IMPROVING ATHLETIC PERFORMANCE
    Publication number: 20080095865
    Abstract: A dietary supplement comprising Creatinol O-Phosphate and Alpha Lipoic Acid, wherein the dietary supplement optionally comprises a timed-release or controlled-release delivery system. The timed-release or controlled-release delivery system may include one of quick release, slow release and controlled release delivery system. By way of oral administration, the present invention provides a method increasing lean muscle mass, increasing muscle strength and improving athletic performance.
    Type: Application
    Filed: October 26, 2007
    Publication date: April 24, 2008
    Applicant: APLODAN FORMULATIONS LTD.
    Inventors: Marvin HEUER, Shan CHAUDHURI, Ken CLEMENT
  • INCREASING ATP AVAILABILITY BY INHIBITION OF CREATINE KINASE (CK) LEAKAGE RESULTING FROM HIGH-INTENSITY EXERCISE
    Publication number: 20080058289
    Abstract: The present invention relates to a method of increasing Adenosine Triphosphate levels in a mammal wherein 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid inhibits the leakage of the Adenosine Triphosphate-dependant enzyme Creatine Kinase. Via the inhibition of Creatine Kinase leakage, Adenosine Triphosphate is not utilized in the conversion of creatine to phosphocreatine, thereby making it available for use in muscular contractions. The increase in availability leads to longer endurance and more forceful muscular contractions.
    Type: Application
    Filed: August 30, 2006
    Publication date: March 6, 2008
    Applicant: Aplodan Formulations Ltd.
    Inventors: James D. Ramsbottom, Jason R. Peters, Shan Chaudhuri
  • METHOD OF INCREASING INTRACELLULAR CONCENTRATIONS OF PHOSPHATE AND INCREASING THE FORCE OF MUSCULAR CONTRACTIONS
    Publication number: 20080058288
    Abstract: The present invention relates to a method of increasing the intracellular concentration of phosphate by employing 2-(carbamimidoyl-methyl-amino)ethoxyphosphonic acid as vehicle and method to transport Phosphate into the cell. The increase in intracellular phosphate increases the availability of Adenosine Triphosphate and phosphocreatine, thereby leading to an increase in the anaerobic energy supply resulting in longer endurance and more forceful muscular contractions.
    Type: Application
    Filed: August 30, 2006
    Publication date: March 6, 2008
    Applicant: APLODAN FORMULATIONS LTD.
    Inventors: James D. RAMSBOTTOM, Jason R. PETERS, Shan CHAUDHURI