Patents Assigned to Apoptogen, Inc.
  • XIAP IRES and uses thereof
    Patent number: 6171821
    Abstract: The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: January 9, 2001
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Martin Holcik, Peter Liston
  • XIAP IRES and uses thereof
    Patent number: 6159709
    Abstract: The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: December 12, 2000
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Martin Holcik, Peter Liston
  • Modulation of IAPs for the treatment of proliferative diseases
    Patent number: 6133437
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: October 17, 2000
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt
  • XAF genes and polypeptides: methods and reagents for modulating apoptosis
    Patent number: 6107088
    Abstract: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: August 22, 2000
    Assignee: Apoptogen Inc.
    Inventors: Robert G. Korneluk, Katsuyuki Tamai, Peter Liston, Alexander E. MacKenzie
  • Detection and modulation of IAPS for the diagnosis and treatment of proliferative disease
    Patent number: 6107041
    Abstract: Disclosed are diagnostic and prognostic kits for the detection and treatment of proliferative diseases such as ovarian cancer, breast cancer, and lymphoma. Also disclosed are cancer therapeutics utilizing IAP antisense nucleic acids IAP fragments, and antibodies which specifically bind IAP polypeptides.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: August 22, 2000
    Assignee: Apoptogen, Inc.
    Inventors: Robert G. Korneluk, Alexander E. MacKenzie, Peter Liston, Stephen Baird, Benjamin K. Tsang, Christine Pratt