Patents Assigned to Aposense Ltd.
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Patent number: 11318206Abstract: A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.Type: GrantFiled: August 17, 2016Date of Patent: May 3, 2022Assignee: APOSENSE LTDInventor: Ilan Ziv
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Patent number: 11286246Abstract: The invention relates to Pro-drugs, comprising red-ox-sensitive cleavage sites. The compounds may be utilized in medical practice for targeting of si RNA, antisense oligonucleotides or protein-based therapeutics to the cytoplasmatic compartment of cells both in vitro or in vivo, in a subject in need.Type: GrantFiled: July 13, 2016Date of Patent: March 29, 2022Assignee: Aposense Ltd.Inventor: Ilan Ziv
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Patent number: 11230710Abstract: A system for delivery of drugs, and especially genetic drugs such as siRNA or antisense oligonucleotides (ASO) across biological membranes is provided. It comprises a trans-membrane delivery moiety, energized by the membrane internal electrical field, and a redox-sensitive disulfide moiety, designed to be reduced at the cytoplasm, thus releasing the cargo drug to exert its pharmaceutical effects at its target sites.Type: GrantFiled: January 9, 2018Date of Patent: January 25, 2022Assignee: Aposense LtdInventors: Ilan Ziv, Joseph Dubrovsky, Hagit Grimberg
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Publication number: 20210052736Abstract: The Invention provides a novel delivery system for delivery of drugs across biological membranes. It provides novel chemical conjugates that comprise said delivery system, methods for synthesis of said compounds, and methods for utilization of said delivery system, among others, for delivery of genetic drugs into tissues and cells, in vitro, ex vivo, and in vivo, for the treatment of various medical disorders.Type: ApplicationFiled: December 31, 2018Publication date: February 25, 2021Applicant: APOSENSE LTDInventors: llan ZIV, Hagit GRIMBERG, JOSEPH DUBROVSKY
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Publication number: 20200392490Abstract: A system for delivery of drugs, and especially genetic drugs such as siRNA or antisense oligonucleotides (ASO) across biological membranes is provided. It comprises a trans-membrane delivery moiety, energized by the membrane internal electrical field, and a redox-sensitive disulfide moiety, designed to be reduced at the cytoplasm, thus releasing the cargo drug to exert its pharmaceutical effects at its target sites.Type: ApplicationFiled: January 9, 2018Publication date: December 17, 2020Applicant: Aposense LTD.Inventors: Ilan ZIV, Joseph DUBROVSKY, Hagit GRIMBERG
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Patent number: 10195286Abstract: A conjugate for delivery of drugs, such as genetic drugs, [e.g., siRNA, dsiRNA, or antisense oligonucleotides (ASO)] across biological membranes is provided. The conjugates of the Invention are capable of delivering drugs in both presence and absence of plasma proteins.Type: GrantFiled: August 31, 2017Date of Patent: February 5, 2019Assignee: Aposense Ltd.Inventors: Ilan Ziv, Hagit Grimberg, Joseph Dubrovsky
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Publication number: 20190008976Abstract: A conjugate for delivery of drugs, such as genetic drugs, [e.g., siRNA, dsiRNA, or antisense oligonucleotides (ASO)]across biological membranes is provided. The conjugates of the Invention are capable of delivering drugs in both presence and absence of plasma proteins.Type: ApplicationFiled: August 31, 2017Publication date: January 10, 2019Applicant: Aposense LTD.Inventors: Ilan ZIV, Hagit GRIMBERG, Joseph DUBROVSKY
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Publication number: 20180243426Abstract: A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.Type: ApplicationFiled: August 17, 2016Publication date: August 30, 2018Applicant: Aposense LTD.Inventor: Ilan ZIV
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Publication number: 20180208574Abstract: The invention relates to Pro-drugs, comprising red-ox-sensitive cleavage sites. The compounds may be utilized in medical practice for targeting of si RNA, antisense oligonucleotides or protein-based therapeutics to the cytoplasmatic compartment of cells both in vitro or in vivo, in a subject in need.Type: ApplicationFiled: July 13, 2016Publication date: July 26, 2018Applicant: Aposense LTD.Inventor: Ilan ZIV
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Patent number: 9993563Abstract: A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.Type: GrantFiled: July 28, 2016Date of Patent: June 12, 2018Assignee: Aposense LTD.Inventor: Ilan Ziv
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Patent number: 9889202Abstract: A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.Type: GrantFiled: October 1, 2015Date of Patent: February 13, 2018Assignee: Aposense LTD.Inventor: Ilan Ziv
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Patent number: 9687556Abstract: A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.Type: GrantFiled: August 20, 2015Date of Patent: June 27, 2017Assignee: Aposense Ltd.Inventor: Ilan Ziv
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Patent number: 9192680Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice for treating pancreatic cancer.Type: GrantFiled: November 13, 2014Date of Patent: November 24, 2015Assignee: Aposense LTD.Inventors: Ilan Ziv, Hagit Grimberg
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Publication number: 20150064111Abstract: The invention relates to compounds and use thereof in the diagnosis and/or in treatment of medical disorders. In some embodiments, the compounds may be used for detecting a cancer. The compound may include a di-acid moiety. In some embodiments the di-acid moiety comprises a di-carboxylic acid and in some embodiments the di-acid moiety comprises a di-tetrazole.Type: ApplicationFiled: April 3, 2013Publication date: March 5, 2015Applicant: APOSENSE LTD.Inventors: Joel M. Van Gelder, Menashe Levy, Mirit Argov, Miri Ben-Ami, Ilan Ziv
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Patent number: 8916537Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.Type: GrantFiled: August 8, 2013Date of Patent: December 23, 2014Assignee: Aposense Ltd.Inventors: Ilan Ziv, Hagit Grimberg
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Publication number: 20130324494Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.Type: ApplicationFiled: August 8, 2013Publication date: December 5, 2013Applicant: Aposense Ltd.Inventors: Ilan ZIV, Hagit Grimberg
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Patent number: 8530444Abstract: Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.Type: GrantFiled: June 1, 2010Date of Patent: September 10, 2013Assignee: Aposense Ltd.Inventors: Ilan Ziv, Hagit Grimberg
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Patent number: 8101666Abstract: The invention provides methods for detection of medical disorders, associated with cellular oxidative stress, cell degeneration and/or cell death. The invention further relates to compounds comprising a thiol (—SH) group, for detecting cells undergoing oxidative stress, degeneration and/or a death process. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes.Type: GrantFiled: July 7, 2005Date of Patent: January 24, 2012Assignee: Aposense Ltd.Inventors: Ilan Ziv, Anat Shirvan
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Patent number: 7947253Abstract: The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for utilizing said compounds in medical practice, for diagnostic and therapeutic purposes.Type: GrantFiled: January 16, 2005Date of Patent: May 24, 2011Assignee: Aposense Ltd.Inventors: Ilan Ziv, Anat Shirvan
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Patent number: 7670590Abstract: The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for utilizing said compounds in medical practice, for diagnostic and therapeutic purposes.Type: GrantFiled: August 2, 2007Date of Patent: March 2, 2010Assignee: Aposense Ltd.Inventors: Ilan Ziv, Anat Shirvan