Abstract: Methods and apparatus for reduction of interference between a plurality of wireless interfaces. In one exemplary embodiment, a device having a first (e.g., Wi-Fi) interface and a second (e.g., Bluetooth) interface monitors interference between its interfaces. A reduction in transmit power of the Wi-Fi module causes a disproportionately larger reduction in undesirable interference experienced at the Bluetooth antennas. For example, when the Bluetooth interface detects interference levels above acceptable thresholds, the Wi-Fi interface adjusts operation of one or more of its transmit chains based on various conditions such as duty cycle, Received Signal Strength Indication (RSSI), etc. Various embodiments of the present invention provide simultaneous operation of WLAN and PAN interfaces, without requiring time division coexistence, by reducing power on a subset of interfering antennas.