Patents Assigned to Applied Biomimetic A/S
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Patent number: 12145109Abstract: A process for the preparation of a filtration membrane, which includes providing an aqueous suspension of vesicles having transmembrane proteins incorporated therein, the vesicles being formed from an amphiphilic block copolymer having reactive end groups; providing a porous support; functionalizing a surface of the porous support to introduce reactive groups on the surface which are capable of reacting with the reactive end groups of the amphiphilic block copolymers of the vesicles; depositing said suspension of vesicles on a surface of the porous support; and providing reaction conditions such that covalent bonds are formed between the vesicles and the surface.Type: GrantFiled: August 16, 2022Date of Patent: November 19, 2024Assignee: APPLIED BIOMIMETIC A/SInventor: Mariusz Piotr Grzelakowski
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Patent number: 11541360Abstract: The invention provides a filtration membrane which comprises a porous support and, covalently bonded to a surface thereof, a layer comprising a plurality of vesicles having transmembrane proteins incorporated therein, said vesicles being formed from an amphiphilic block copolymer; characterised in that within said layer, vesicles are covalently linked together to form a coherent mass. The membrane may be prepared by a process which comprises providing an aqueous suspension of vesicles having transmembrane proteins incorporated therein, said vesicles being formed from an amphiphilic block copolymer having reactive end groups; depositing said suspension of vesicles on a surface of a porous support; and providing reaction conditions such that covalent bonds are formed between different vesicles and between vesicles and said surface.Type: GrantFiled: February 18, 2020Date of Patent: January 3, 2023Assignee: APPLIED BIOMIMETIC A/SInventor: Mariusz Piotr Grzelakowski
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Patent number: 11247179Abstract: A method of preparing a membrane comprising the steps of: a) mixing together a membrane-forming polymer, a water-soluble polyetheramine, and a solvent, said mixture containing no component which will react chemically with the polyetheramine; and b) casting said mixture to form the polymer into a solid membrane.Type: GrantFiled: November 21, 2016Date of Patent: February 15, 2022Assignee: APPLIED BIOMIMETIC A/SInventors: Mariusz Piotr Grzelakowski, Yan Zhang
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Patent number: 11231019Abstract: An electricity generation process is disclosed. The process comprises injecting an aqueous feed stream into a salt formation to dissolve the salt contained therein, and then extracting a saline stream containing said dissolved salt from the salt formation. The process also comprises converting latent osmotic energy present in said saline stream into electricity by passage through an osmotic power unit comprising a semi-permeable membrane which permits the passage of water but not the passage of salts in which said saline stream is passed over one side of the semi-permeable membrane, a low salinity stream being passed over the other side of said membrane. The process also comprises using an output stream derived from the low salinity stream as the aqueous feed stream.Type: GrantFiled: March 2, 2017Date of Patent: January 25, 2022Assignee: APPLIED BIOMIMETIC A/SInventor: Steen Søndergaard Nissen
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Patent number: 10968128Abstract: A process for the generation of power is disclosed. The process comprises receiving a wastewater stream containing organic matter and passing the wastewater stream to an anaerobic digester in which the organic matter contained therein is broken down to produce biogas. The liquid content of said wastewater stream is reduced before said stream enters the anaerobic digester by passing the wastewater stream through an osmotic power unit. The said stream is passed over one side of a semi-permeable membrane which permits the passage of water but not the passage of salts, an aqueous stream of higher salinity than said wastewater stream being passed over the other side of said membrane such that latent osmotic energy present in said aqueous stream of higher salinity is converted into electricity.Type: GrantFiled: March 2, 2017Date of Patent: April 6, 2021Assignee: APPLIED BIOMIMETIC A/SInventor: Steen Søndergaard Nissen
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Patent number: 10865278Abstract: Vesicles formed from a block copolymer comprising at least one (poly)2-C1-3alkyl-2-oxazoline block and at least one polybutadiene block; and membranes comprising such vesicles. Block copolymers comprising at least one (poly)2-C1-3alkyl-2-oxazoline block and at least one polybutadiene block, provided that the copolymer is not the diblock copolymer consisting of 40 butadiene units and 190 2-methyl-2-oxazoline units terminated by a hydroxy group, are novel, and also form part of the invention.Type: GrantFiled: March 24, 2016Date of Patent: December 15, 2020Assignees: APPLIED BIOMIMETIC A/S, THE PENN STATE RESEARCH FOUNDATIONInventors: Mariusz Piotr Grzelakowski, Manish Kumar, Ian T. Sines
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Publication number: 20200255311Abstract: A process for the generation of power is disclosed. The process comprises receiving a wastewater stream containing organic matter and passing the wastewater stream to an anaerobic digester in which the organic matter contained therein is broken down to produce biogas. The liquid content of said wastewater stream is reduced before said stream enters the anaerobic digester by passing the wastewater stream through an osmotic power unit. The said stream is passed over one side of a semi-permeable membrane which permits the passage of water but not the passage of salts, an aqueous stream of higher salinity than said wastewater stream being passed over the other side of said membrane such that latent osmotic energy present in said aqueous stream of higher salinity is converted into electricity.Type: ApplicationFiled: March 2, 2017Publication date: August 13, 2020Applicant: Applied Biomimetic A/SInventor: Steen Søndergaard Nissen
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Patent number: 10576434Abstract: The invention provides a filtration membrane which comprises a porous support and, covalently bonded to a surface thereof, a layer comprising a plurality of vesicles having transmembrane proteins incorporated therein, said vesicles being formed from an amphiphilic block copolymer; characterised in that within said layer, vesicles are covalently linked together to form a coherent mass. The membrane may be prepared by a process which comprises providing an aqueous suspension of vesicles having transmembrane proteins incorporated therein, said vesicles being formed from an amphiphilic block copolymer having reactive end groups; depositing said suspension of vesicles on a surface of a porous support; and providing reaction conditions such that covalent bonds are formed between different vesicles and between vesicles and said surface.Type: GrantFiled: March 24, 2015Date of Patent: March 3, 2020Assignee: Applied Biomimetic A/SInventor: Mariusz Piotr Grzelakowski
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Publication number: 20190093639Abstract: An electricity generation process is disclosed. The process comprises injecting an aqueous feed stream into a salt formation to dissolve the salt contained therein, and then extracting a saline stream containing said dissolved salt from the salt formation. The process also comprises converting latent osmotic energy present in said saline stream into electricity by passage through an osmotic power unit comprising a semi-permeable membrane which permits the passage of water but not the passage of salts in which said saline stream is passed over one side of the semi-permeable membrane, a low salinity stream being passed over the other side of said membrane. The process also comprises using an output stream derived from the low salinity stream as the aqueous feed stream.Type: ApplicationFiled: March 2, 2017Publication date: March 28, 2019Applicant: Applied Biomimetic A/SInventor: Steen Søndergaard Nissen
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Patent number: 10100816Abstract: A process for the generation of electricity comprises the steps of extracting a warm saline stream from a geothermal formation, and converting latent osmotic energy present in said stream into electricity by passage through an osmotic power unit in which said stream is passed over one side of a semi-permeable membrane which permits the passage of water but not the passage of salts, an aqueous stream of lower salinity than said stream being passed over the other side of said membrane. The temperature of said warm saline stream is reduced before said stream enters the osmotic power unit by passage through a thermal power unit in which thermal energy present in said stream is converted into electricity.Type: GrantFiled: September 8, 2015Date of Patent: October 16, 2018Assignee: APPLIED BIOMIMETIC A/SInventors: Steen Søndergaard Nissen, Jørgen Mads Clausen
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Patent number: 9994682Abstract: Novel block copolymers comprising at least one (poly)2-C1-3alkyl-2-oxazoline block and at least one (poly)dimethyl siloxane block, having at least one end group X which includes both an —NH2 group and an —NH— group, have been found to be particularly suitable for forming vesicles. The vesicles may be used to form filtration membranes.Type: GrantFiled: March 24, 2015Date of Patent: June 12, 2018Assignee: APPLIED BIOMIMETIC A/SInventor: Mariusz Piotr Grzelakowski
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Patent number: 9440195Abstract: The present invention relates to a method for producing man-made devices which have the properties and functions of biological membranes and membrane proteins, and to the structure of such devices. Briefly, in one aspect of the invention, natural or genetically engineered proteins are incorporated into a polymeric vesicle that is conjugated to a thread to form a vesicle-thread conjugate. The engineered protein is preferably a transmembrane protein embedded in the wall of the polymeric vesicle. The vesicle-thread conjugate is then formed into a membrane or thin fabric having a wide variety of inherent functionality, including the ability to selectively transport and/or filter compounds between fluids. By selecting proteins with specific properties, membranes can be fabricated with a defined functionality including molecular scale addressability via directed electrostatic, electromagnetic, and chemical forces.Type: GrantFiled: October 6, 2009Date of Patent: September 13, 2016Assignee: Applied Biomimetic A/SInventor: Carlo D. Montemagno
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Patent number: 9359230Abstract: The present invention generally related to a nanofabricated membrane including polymerized proteoliposomes. The nanofabricated membrane is a bio-nano fused selective membrane using protein-incorporated uv-crosslinkable liposomes with a chemical reactive biocompatible interstitial matrix. In the present invention, internally UV-crosslinked protein-incorporated proteolipsomes are used because the proteoliposomes made by natural lipids have a short life time and a weak resistance to the circumstantial stresses such as a high and low temperature, pressure, ionic strength etc. Furthermore, the proteo-vesicles made by amphiphilic block copolymers provide less consistency in accomplishing proper functionality batch to batch because of the inevitable polydiversity of the polymer.Type: GrantFiled: February 3, 2010Date of Patent: June 7, 2016Assignee: Applied Biomimetic A/SInventors: Carlo Montemagno, Chandrasmitha Bhatt, Jinsoo Yi, Theiss Stenstroem