Patents Assigned to Applied BioPhysics, Inc.
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Patent number: 9321989Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.Type: GrantFiled: November 3, 2015Date of Patent: April 26, 2016Assignee: APPLIED BIOPHYSICS, INC.Inventor: Christian W. Renken
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Publication number: 20160053215Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.Type: ApplicationFiled: November 3, 2015Publication date: February 25, 2016Applicant: APPLIED BIOPHYSICS, INC.Inventor: Christian W. RENKEN
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Patent number: 9186669Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.Type: GrantFiled: February 10, 2012Date of Patent: November 17, 2015Assignee: APPLIED BIOPHYSICS, INC.Inventor: Christian W. Renken
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Patent number: 8722393Abstract: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying at least one electrical pulse to the at least one electrode to prevent cells from attaching to and achieving confluence over the at least one electrode while allowing cells to attach to and achieve confluence over other portions of the well substrate; and discontinuing the periodically applying of the at least one electrical pulse to the at least one electrode after cells have achieved confluence over the other portions of the well substrate, and thereafter, monitoring the cell culture to monitor migration of cells over the electrode(s) from the other portions of the well substrate.Type: GrantFiled: July 23, 2012Date of Patent: May 13, 2014Assignee: Applied Biophysics, Inc.Inventors: Ivar Giaever, Charles R. Keese
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Publication number: 20130210131Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.Type: ApplicationFiled: February 10, 2012Publication date: August 15, 2013Applicant: APPLIED BIOPHYSICS, INC.Inventor: Christian W. RENKEN
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Publication number: 20120288922Abstract: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying at least one electrical pulse to the at least one electrode to prevent cells from attaching to and achieving confluence over the at least one electrode while allowing cells to attach to and achieve confluence over other portions of the well substrate; and discontinuing the periodically applying of the at least one electrical pulse to the at least one electrode after cells have achieved confluence over the other portions of the well substrate, and thereafter, monitoring the cell culture to monitor migration of cells over the electrode(s) from the other portions of the well substrate.Type: ApplicationFiled: July 23, 2012Publication date: November 15, 2012Applicant: APPLIED BIOPHYSICS, INC.Inventors: Ivar GIAEVER, Charles R. KEESE
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Patent number: 8227223Abstract: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying at least one electrical pulse to the at least one electrode to prevent cells from attaching to and achieving confluence over the at least one electrode while allowing cells to attach to and achieve confluence over other portions of the well substrate; and discontinuing the periodically applying of the at least one electrical pulse to the at least one electrode after cells have achieved confluence over the other portions of the well substrate, and thereafter, monitoring the cell culture to monitor migration of cells over the electrode(s) from the other portions of the well substrate.Type: GrantFiled: January 27, 2009Date of Patent: July 24, 2012Assignee: Applied Biophysics, Inc.Inventors: Ivar Giaever, Charles R. Keese
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Publication number: 20100190228Abstract: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying at least one electrical pulse to the at least one electrode to prevent cells from attaching to and achieving confluence over the at least one electrode while allowing cells to attach to and achieve confluence over other portions of the well substrate; and discontinuing the periodically applying of the at least one electrical pulse to the at least one electrode after cells have achieved confluence over the other portions of the well substrate, and thereafter, monitoring the cell culture to monitor migration of cells over the electrode(s) from the other portions of the well substrate.Type: ApplicationFiled: January 27, 2009Publication date: July 29, 2010Applicant: APPLIED BIOPHYSICS, INC.Inventors: Ivar GIAEVER, Charles R. KEESE
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Patent number: 7399631Abstract: The present invention provides methods for the assessment of the metastatic potential of cells by measuring the effect of the cells on the impedance of an electrode. Accordingly, the present invention similarly provides methods for establishing indicators of metastatic potential based on a cell's effect on impedance. Such methods may be employed in vitro or in vivo. In some embodiments, the electrode is coated with endothelial or epithelial cells.Type: GrantFiled: September 10, 2004Date of Patent: July 15, 2008Assignee: Applied Biophysics, Inc.Inventors: Ivar Giaever, Charles R. Keese
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Patent number: 7332313Abstract: A method and system for electrically wounding and/or monitoring cell activity in vitro. The invention comprises methods and systems for wounding and/or monitoring cells that place a cell culture on a well that has an exposed electrode. The cell culture can then be wounded and/or monitored using the electrode.Type: GrantFiled: June 5, 2002Date of Patent: February 19, 2008Assignee: Applied BioPhysics, Inc.Inventors: Ivar Giaever, Charles R. Keese
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Publication number: 20020182591Abstract: A method and system for electrically wounding and/or monitoring cell activity in vitro. The invention comprises methods and systems for wounding and/or monitoring cells that place a cell culture on a well that has an exposed electrode. The cell culture can then be wounded and/or monitored using the electrode.Type: ApplicationFiled: June 5, 2002Publication date: December 5, 2002Applicant: Applied BioPhysics, Inc.Inventors: Ivar Giaever, Charles R. Keese