Patents Assigned to Applied BioPhysics, Inc.
  • Patent number: 9321989
    Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: April 26, 2016
    Assignee: APPLIED BIOPHYSICS, INC.
    Inventor: Christian W. Renken
  • Publication number: 20160053215
    Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.
    Type: Application
    Filed: November 3, 2015
    Publication date: February 25, 2016
    Applicant: APPLIED BIOPHYSICS, INC.
    Inventor: Christian W. RENKEN
  • Patent number: 9186669
    Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: November 17, 2015
    Assignee: APPLIED BIOPHYSICS, INC.
    Inventor: Christian W. Renken
  • Patent number: 8722393
    Abstract: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying at least one electrical pulse to the at least one electrode to prevent cells from attaching to and achieving confluence over the at least one electrode while allowing cells to attach to and achieve confluence over other portions of the well substrate; and discontinuing the periodically applying of the at least one electrical pulse to the at least one electrode after cells have achieved confluence over the other portions of the well substrate, and thereafter, monitoring the cell culture to monitor migration of cells over the electrode(s) from the other portions of the well substrate.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: May 13, 2014
    Assignee: Applied Biophysics, Inc.
    Inventors: Ivar Giaever, Charles R. Keese
  • Publication number: 20130210131
    Abstract: A filter device is provided which includes a well, at least one top access opening to the well, and a horizontally-disposed filter. The well, which includes an inner surface at least partially defining the well, also includes a first well chamber to accommodate a fluid and a second well chamber to accommodate a fluid. The first well chamber and the second well chamber are separate chambers, and the inner surface at least partially defines the first well chamber and at least partially defines the second well chamber. The at least one top access opening provides independent top access to the first well chamber and the second well chamber, and the horizontally-disposed filter is positioned between and at least partially separates the separate first well chamber and second well chamber of the well.
    Type: Application
    Filed: February 10, 2012
    Publication date: August 15, 2013
    Applicant: APPLIED BIOPHYSICS, INC.
    Inventor: Christian W. RENKEN
  • Publication number: 20120288922
    Abstract: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying at least one electrical pulse to the at least one electrode to prevent cells from attaching to and achieving confluence over the at least one electrode while allowing cells to attach to and achieve confluence over other portions of the well substrate; and discontinuing the periodically applying of the at least one electrical pulse to the at least one electrode after cells have achieved confluence over the other portions of the well substrate, and thereafter, monitoring the cell culture to monitor migration of cells over the electrode(s) from the other portions of the well substrate.
    Type: Application
    Filed: July 23, 2012
    Publication date: November 15, 2012
    Applicant: APPLIED BIOPHYSICS, INC.
    Inventors: Ivar GIAEVER, Charles R. KEESE
  • Patent number: 8227223
    Abstract: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying at least one electrical pulse to the at least one electrode to prevent cells from attaching to and achieving confluence over the at least one electrode while allowing cells to attach to and achieve confluence over other portions of the well substrate; and discontinuing the periodically applying of the at least one electrical pulse to the at least one electrode after cells have achieved confluence over the other portions of the well substrate, and thereafter, monitoring the cell culture to monitor migration of cells over the electrode(s) from the other portions of the well substrate.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: July 24, 2012
    Assignee: Applied Biophysics, Inc.
    Inventors: Ivar Giaever, Charles R. Keese
  • Publication number: 20100190228
    Abstract: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying at least one electrical pulse to the at least one electrode to prevent cells from attaching to and achieving confluence over the at least one electrode while allowing cells to attach to and achieve confluence over other portions of the well substrate; and discontinuing the periodically applying of the at least one electrical pulse to the at least one electrode after cells have achieved confluence over the other portions of the well substrate, and thereafter, monitoring the cell culture to monitor migration of cells over the electrode(s) from the other portions of the well substrate.
    Type: Application
    Filed: January 27, 2009
    Publication date: July 29, 2010
    Applicant: APPLIED BIOPHYSICS, INC.
    Inventors: Ivar GIAEVER, Charles R. KEESE
  • Patent number: 7399631
    Abstract: The present invention provides methods for the assessment of the metastatic potential of cells by measuring the effect of the cells on the impedance of an electrode. Accordingly, the present invention similarly provides methods for establishing indicators of metastatic potential based on a cell's effect on impedance. Such methods may be employed in vitro or in vivo. In some embodiments, the electrode is coated with endothelial or epithelial cells.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: July 15, 2008
    Assignee: Applied Biophysics, Inc.
    Inventors: Ivar Giaever, Charles R. Keese
  • Patent number: 7332313
    Abstract: A method and system for electrically wounding and/or monitoring cell activity in vitro. The invention comprises methods and systems for wounding and/or monitoring cells that place a cell culture on a well that has an exposed electrode. The cell culture can then be wounded and/or monitored using the electrode.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: February 19, 2008
    Assignee: Applied BioPhysics, Inc.
    Inventors: Ivar Giaever, Charles R. Keese
  • Publication number: 20020182591
    Abstract: A method and system for electrically wounding and/or monitoring cell activity in vitro. The invention comprises methods and systems for wounding and/or monitoring cells that place a cell culture on a well that has an exposed electrode. The cell culture can then be wounded and/or monitored using the electrode.
    Type: Application
    Filed: June 5, 2002
    Publication date: December 5, 2002
    Applicant: Applied BioPhysics, Inc.
    Inventors: Ivar Giaever, Charles R. Keese